Navigation Links
Study of Mechanism of Action of Ibrutinib in Mantle Cell Lymphoma Published in Blood - Journal of the American Society of Hematology
Date:8/22/2013

onses," said Betty Chang, Vice President of Research Biology at Pharmacyclics.

About Mantle Cell Lymphoma
MCL is a B-cell malignancy, an aggressive type of B-cell non-Hodgkin lymphoma (NHL) that usually occurs in older adults.i The disease typically begins in the lymph nodes, but can spread to other tissues, such as bone marrow, liver, and spleen.ii Patients typically survive an average of five years.iii  There are approximately 5,600 new cases of MCL each year in the G7 (U.S., France, Germany, Italy, Spain, U.K., and Japan) and a prevalence of about 23,000 patients (Decision Resources 2012).

About Ibrutinib
Ibrutinib is an investigational agent designed to provide potent and sustained inhibition of an enzyme called Bruton's tyrosine kinase (BTK). BTK is a key mediator of at least three critical B-cell pro-survival mechanisms occurring in parallel – regulation of apoptosis, adhesion, and cell migration and homing. Through these multiple signals, BTK regulation helps to direct malignant B-cells to lymphoid tissues, thus allowing access to a micro-environment necessary for survival.

The effectiveness of ibrutinib alone or in combination with other treatments is being studied in several B-cell malignancies, including chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Waldenstrom's macroglobulinemia and multiple myeloma. To date, 7 Phase III trials have been initiated with ibrutinib and a total of 31 trials are currently registered on www.clinicaltrials.gov. Janssen and Pharmacyclics entered a collaboration and license agreement in

SOURCE Pharmacyclics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Final Patient Completes Prosonix Phase 2 Clinical Study with PSX1002 in Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
2. Boehringer Ingelheim Announces Agreement to Study Real-World Use of Oral Anticoagulants
3. Celsion Corporation Reports Second Quarter 2013 Financial Results and Provides HEAT Study Update
4. Isis Pharmaceuticals Reports Data From a Phase 2 Study of Isis-CRP Rx in Patients with Rheumatoid Arthritis
5. GW Pharmaceuticals Announces Results of MS Spasticity Study Confirming Sativex Has No Long-Term Negative Effect on Cognition
6. Astellas Confirms Interim Analysis in PREVAIL Study of XTANDI will Occur within Calendar Year 2013
7. Physicians Expect More Out of Tablet-Toting Pharmaceutical Sales Reps, Study Finds
8. Nektar Completes Enrollment in Phase 3 BEACON Study of Etirinotecan Pegol in Women With Metastatic Breast Cancer
9. Mechanism for Cardiac Effects of Trevena Angiotensin Receptor Biased Ligands Examined in Published Study
10. EntreMed Initiates Crossover Bioavailability And Food Effect Study Of ENMD-2076 Dosage Form To Be Used For Pivotal/Registration Clinical Trials
11. Recent Study Reveals Physicians Prefer Topical Delivery for Drug Delivery Technology, Such as a Transdermal Patch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... DUBLIN , Aug. 29, 2014 ... the "Global Multiple Sclerosis Drugs Market 2014-2018" ... is a chronic, inflammatory medical condition that results in ... damaged because of an abnormal response by the immune ... (CNS). It is a potentially debilitating disease in which ...
(Date:8/29/2014)... 29, 2014  Abaxis, Inc. (NasdaqGS: ABAX ... and consumables to the medical, research and veterinary markets, ... Chief Executive Officer, will present at the CL King ... Tuesday, September 9, 2014 at 12:30 p.m. ET. The ... Hotel in New York City . ...
(Date:8/29/2014)... VANCOUVER, British Columbia and MENLO ... -- DelMar Pharmaceuticals, Inc. (OTCQB: DMPI) ("DelMar" ... 2014 fiscal year-end financial statements.  The Company recently changed ... to facilitate an application to list its common stock ... possible. DelMar,s financial statements as filed with ...
Breaking Medicine Technology:Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 4DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 5
... ALEXANDRIA, Va., April 14, 2011 Oxford Finance Corporation ... it closed a $2 million equipment loan with Synta ... to manufacture compounds for use in Synta,s ongoing clinical ... diseases. "Synta Pharmaceuticals has a diverse drug ...
... April 14, 2011 Beacon Enterprise Solutions Group, ... emerging global leader in the design, implementation and ... today announces the signing of a third US-based ...   http://photos.prnewswire.com/prnh/20101021/DA85933LOGO ) Beacon has ...
Cached Medicine Technology:Oxford Finance Corporation Provides a $2 Million Equipment Facility to Synta Pharmaceuticals Corp. 2Beacon Announces Agreement With New Fortune 500 Pharmaceutical Client 2Beacon Announces Agreement With New Fortune 500 Pharmaceutical Client 3
(Date:9/1/2014)... September 01, 2014 Registration is now open ... 5K and 1-Mile Race to be held on Sunday, September ... Court Yard at Harmon Meadow in Secaucus, New Jersey. All ... a national nonprofit dedicated to restoring a sense of self, ... members and our military families. , General registration is $30 ...
(Date:9/1/2014)... Daily Gossip reveals in it's review ... that gives members access to thousands of professionally designed ... resource aims to help both people who plan on ... are looking for inspiration in creating one of a ... Now by visiting the official website at: http://www.dailygossip.org/atattoo-me-now-6444 ...
(Date:9/1/2014)... Pastor Thompson is an ordained minister and previously ... is a licensed minister through the Church of the Nazarene ... in New Mexico, Colorado and North Dakota. He and his ... He also has two beautiful daughters, Brianna, 22 and ... from Nazarene Bible College, in Colorado Springs and is currently ...
(Date:9/1/2014)... September 01, 2014 Psychogenic Non-epileptic Seizures ... a psychological disorder that can have devastating effects on ... like epileptic seizures however, they are not produced by ... triggers. It is estimated that the numbers of ... by multiple sclerosis. , Dr. Lorna Myers, ...
(Date:8/31/2014)... August 31, 2014 MYMOBILEUNI (MMU) ... utilizing social media marketing tools access to digital, ... MMU will utilize all tools to reach and ... for our multiple learning channels. , MMU, today ... and an authoring tool that applies social networking ...
Breaking Medicine News(10 mins):Health News:Hope For The Warriors New Jersey Run to Honor Wounded and Families of the Fallen 2Health News:Tattoo Me Now Review Reveals Unique Ideas for Tattoo Designs 2Health News:The Northeast Regional Epilepsy Group (NEREG) Offers First Conference on Psychogenic Non-epileptic Seizures (PNES) on September 20, 2014 in New Jersey 2Health News:My Mobile University Announces Global Strategic Plan and Unveils New Android App to Enhance and Impact Lives World-Wide Through Education for All as Learning Platform 2Health News:My Mobile University Announces Global Strategic Plan and Unveils New Android App to Enhance and Impact Lives World-Wide Through Education for All as Learning Platform 3
... ... What can we do about that? Awareness is the first step toward responsible and ... (PRWEB) March ... but also for the health of the consumer. Conventional clothing has chemical residues which ...
... Three ... and pulmonary embolism (PE), a growing public health problem estimated to affect nearly 1 ... ... national workshop have been released to address deep-vein thrombosis (DVT) and pulmonary embolism (PE), ...
... possible long-term effects, experts say, , WEDNESDAY, March 10 ... be an alternative to the widely used statin medications ... and American researchers report. , In the trial, various ... thyroid hormone, were added to statin treatment for 168 ...
... , ... ... ... Funds from Operations Modified (FFOM), excluding the non-recurring events summarized below, for fourth quarter 2009 was $7.9 million , or $0.16 per share and operating partnership unit. , ...
... ultrasound guidance, treating tumors with extreme heat or moderate ... early research presented at the second AACR Dead Sea ... Laboratory to the Clinic, held March 7-10, 2010. ... are beneficial in curing both malignant and benign tumors ...
... BLACKBURN, United Kingdom , March 10 Will the Rt Hon Andy Burnham MP Ban all Tobacco products on 21st June 2010 ? , ... , , ... ... The MHRA, the nation,s Health regulators, have created for Mr. ...
Cached Medicine News:Health News:Organic Clothing can be as Crucial to Your Health as Organic Food or Yoga 2Health News:Organic Clothing can be as Crucial to Your Health as Organic Food or Yoga 3Health News:Critical Recommendations Unveiled to Respond to National Public Health Crisis: Deep-Vein Thrombosis and Pulmonary Embolism 2Health News:Critical Recommendations Unveiled to Respond to National Public Health Crisis: Deep-Vein Thrombosis and Pulmonary Embolism 3Health News:Critical Recommendations Unveiled to Respond to National Public Health Crisis: Deep-Vein Thrombosis and Pulmonary Embolism 4Health News:Critical Recommendations Unveiled to Respond to National Public Health Crisis: Deep-Vein Thrombosis and Pulmonary Embolism 5Health News:Alternative to Statins Shows Promise 2Health News:Alternative to Statins Shows Promise 3Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 2Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 3Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 4Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 5Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 6Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 7Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 8Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 9Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 10Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 11Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 12Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 13Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 14Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 15Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 16Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 17Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 18Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 19Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 20Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 21Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 22Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 23Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 24Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 25Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 26Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 27Health News:Cogdell Spencer Inc. Reports Fourth Quarter and Year End 2009 Financial Results 28
Disposable Cannula Cuffless Tracheostomy Tubes...
Disposable Cannula Cuffed Tracheostomy Tubes...
... CARE Double Swivel Elbow is designed ... provide flexibility without connectors. Features one ... for better feel. Numbered catheter allows ... catheter advance. Offers multiple tracheostomy sizes, ...
... soft, flexible whistle tip suction catheter ... that includes: One pair of vinyl ... ml bottle of sterile saline. Components ... with cuffed gloves and catheter inside ...
Medicine Products: