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Study of Mechanism of Action of Ibrutinib in Mantle Cell Lymphoma Published in Blood - Journal of the American Society of Hematology
Date:8/22/2013

SUNNYVALE, Calif., Aug. 22, 2013 /PRNewswire/ -- Pharmacyclics, Inc. (Nasdaq: PCYC) announced today the publication of a study that investigated the mechanism of ibrutinib's anti-tumor effect in patients with mantle cell lymphoma (MCL) in Blood,  the most cited peer-reviewed journal in the field of hematology.  The article was pre-published online shortly after acceptance in manuscript format as a First Edition Paper.

Response of MCL patients to ibrutinib was noted during early clinical trials to be accompanied by increases in absolute lymphocyte count (ALC) in the peripheral blood.  MCL cells typically grow in the lymph nodes and tissues where they receive signals and support that are essential for their survival and growth.  In the current paper, Pharmacyclics Vice President of Research, Betty Chang, along with colleagues and collaborators, showed that the lymphocytes, which increase in the peripheral blood during ibrutinib treatment, are MCL cells rather than normal cells.  Moreover, the data indicate ibrutinib may directly and potently inhibit MCL cell adhesion and migration in the residing lymph nodes or tissues. This publication illustrates these cells show decreases of markers of activation and growth as treatment continued and nodal responses were observed.  

"For the first time, we demonstrate that the increase in lymphocytes in the peripheral blood is due to an egress of MCL cells from tissues, such as the lymph nodes.  Following ibrutinib treatment these cells are released in a matter of days into the peripheral blood where they are then quickly cleared systemically.  This general mechanism was previously postulated for BCR antagonists in CLL but it is now characterized in detail in MCL showing how ibrutinib can lead to the observed resp
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SOURCE Pharmacyclics, Inc.
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