Navigation Links
Study of First-in-Class WATCHMAN® Device Shows 75 Percent Reduction in Stroke Risk in Patients with Atrial Fibrillation Not Eligible for Oral Anticoagulation Therapy
Date:5/11/2012

larly and pump blood efficiently.  Patients in atrial fibrillation are at greater risk for stroke due to the migration of clots formed in the left atrial appendage (LAA).  Anticoagulants such as warfarin have traditionally been the only therapy for reducing stroke risk in these patients.  The Boston Scientific percutaneously delivered WATCHMAN Device is an alternative to long-term anticoagulation in patients eligible for anticoagulant therapy.  It is designed to close the LAA, thereby preventing clots forming within the appendage and being dislodged into the bloodstream where they can potentially cause a stroke. 

"Findings from the ASAP Study are promising in that closure of the LAA with the WATCHMAN Device produced a significant reduction in the expected ischemic stroke rate for this patient population," said Dr. Reddy.  "These results are very impressive and show potential for an effective device-based solution for higher-risk patients with limited pharmacologic options to reduce their risk of stroke."

For patients in the ASAP Study, the average baseline CHADS2 score of 2.8 equated to a predicted ischemic stroke rate of approximately 7.1 percent per year.  The observed rate of ischemic stroke for patients implanted with the WATCHMAN Device was 1.7 percent per year, a 75 percent reduction in stroke risk from the predicted stroke rate based on the CHADS2 score (p<0.01).  The corresponding upper confidence bound yielded a stroke rate of 4.4 percent per year, lower than the predicted stroke rate of 7.1 percent. 

Stroke rates in the ASAP study were similar to those observed in the PROTECT AF study, which assessed similar subjects not contraindicated to warfarin.
In the multi-center, randomized PROTECT AF trial, the WATCHMAN Device proved to be non-inferior to warfarin and demonstrated a 38 percent relative risk reduction for stroke, cardiovascular death and systemic embolism compared to long-term
'/>"/>

SOURCE Boston Scientific Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Study Shows NxStage Daily Home Hemodialysis Patients More Likely to Receive Kidney Transplant
2. Life Extension Foundation® study finds Cognitex® with NeuroProtection Complex may provide a positive impact on cognitive performance
3. Data from Study of Elderly Depressed Patients are Reported for Investigational Compound Lu AA21004 on Symptoms of Major Depressive Disorder (MDD)
4. Inaugural Harris Poll Physician Pulse(SM) Study: Viagra® and Cialis® are Highest Ranked in Trust
5. Alder BioPharmaceuticals Inc. Initiates Phase 1 Clinical Study of Antibody Therapeutic Candidate for Treatment of Migraine, ALD403
6. Staffing and Performance Benchmarks for Quality Function Highlight New Medical Device Study
7. Isis Initiates Phase 2 Study of ISIS-APOCIIIRx in Patients with Hypertriglyceridemia
8. CSL Behring Initiates Study of Subcutaneous Administration of C1-esterase Inhibitor in Patients with Hereditary Angioedema
9. Study Results Demonstrate Analytical Treatment Interruption to Assess Antiviral Activity of Argoss Arcelis™ Personalized Immunotherapy for Treatment of HIV Patients, AGS-004, Is Acceptable Strategy for At Least 16 Weeks
10. National Study: Teen "Heavy" Marijuana Use Up 80 Percent Since 2008, One in Ten Teens Reports Using Marijuana at Least 20 Times a Month
11. Michael J. Fox Foundation-Funded Study Identifies Best Dyskinesia Clinical Rating Scale
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2015)... WASHINGTON , Feb. 26, 2015 Legislation ... includes a pharmacy provision to help prevent inappropriate prescriptions ... The Protecting the Integrity of Medicare Act (PIMA) ... Subcommittee Chairman Kevin Brady (R-TX) and Ranking ... the prescription drug abuse epidemic and implement the right ...
(Date:2/26/2015)... , Feb. 26, 2015 Research and Markets ... the "Radiation Therapy Equipment - Global Strategic Business ... This report analyzes the worldwide markets for Radiation Therapy ... Linear Accelerator, Treatment Planning Systems, and Radiation Therapy Simulator. ... Canada , Japan ...
(Date:2/26/2015)... 2015  Spring Bank Pharmaceuticals, Inc., a clinical-stage ... of virus infections, today announced that Jonathan ... President of Finance, a newly created role.  Mr. ... activities, including financial planning and reporting, accounting and ... Jensen , President and CEO. ...
Breaking Medicine Technology:PCMA Statement on the 'Protecting the Integrity of Medicare Act' 2Radiation Therapy Equipment - Global Strategic Business Report 2015-2020: Linear Accelerator, Treatment Planning Systems, and Radiation Therapy Simulator 2Jonathan P. Freve, CPA, Joins Spring Bank Pharmaceuticals as Vice President of Finance 2
(Date:2/27/2015)... February 27, 2015 Muscular Dystrophy ... Biomedical Engineering at Duke University, recently announced a ... and young men with Duchenne muscular dystrophy (DMD). ... Communications, and Gersbach will discuss their implications at ... 11-14 in Washington, D.C. , Background: Gersbach ...
(Date:2/27/2015)... According to the report, the annual revenue ... in 2013 rose by 31.9%. However, in the first ... generated by the industry was recorded at RMB3.623 billion ... industry in 2013. , View Full Report at ... oral industry as a branch of medical industry that ...
(Date:2/27/2015)... Lake City, UT (PRWEB) February 27, 2015 ... Best and Worst Commuter Cities in Florida " ... traffic data from the 2013 U.S. Census Bureau ... 10,000 at the time of the survey. , ... city level, including methods of commuting and a ...
(Date:2/27/2015)... On time and under budget, the doors ... Inside and out, the nearly 900,000-square-foot facility makes good ... the tornado-ravaged St. John’s Regional Medical Center with a ... just 46 months after the tornado hit Joplin, which ... to plan, design and construct a similarly sized hospital,” ...
(Date:2/27/2015)... Fairfax, VA (PRWEB) February 27, 2015 ... currently accepting applications for its next class of Fellows ... the field of radiology business management. , Since ... the significant contributions made by RBMA members to the ... is a prestigious recognition because each Fellow candidate must ...
Breaking Medicine News(10 mins):Health News:Statement: New MDA-Funded Genetic Therapy Technique Targets DMD 2Health News:China Dental Industry to Expand Rapidly Owing to the Evolution of Medical and Healthcare Systems: MarketResearchReports.Biz 2Health News:China Dental Industry to Expand Rapidly Owing to the Evolution of Medical and Healthcare Systems: MarketResearchReports.Biz 3Health News:40 Best and Worst Commuter Cities in Florida Announced by Obrella 2Health News:New Hospital Built to Stand Against Nature 2Health News:New Hospital Built to Stand Against Nature 3Health News:New Hospital Built to Stand Against Nature 4Health News:RBMA Issues Call for Fellowship Applicants 2
... with rheumatoid arthritis who undergo total knee replacement ... according to a new study by researchers at ... City. These reduced expectations, which may be unnecessary, ... postsurgical rehabilitation leading to worse outcomes, say doctors. ...
... , SATURDAY, Nov. 5 (HealthDay News) -- Exposure to certain ... for the painful joint disease known as rheumatoid arthritis, new ... one of the six most common air pollutants in the ... to be presented Wednesday at the American College of Rheumatology ...
... HealthDay Reporter , FRIDAY, Nov. 4 (HealthDay News) -- A ... identifying a gene that is critical in determining which life-saving ... by Genomic Health, results in a number of false-negatives for ... in the Journal of Clinical Oncology . ...
... Cholesterol-lowering medications may help millions fight heart ... control, according to a study presented at the American ... Boston, Nov. 3-8. In the preliminary study ... medication or statins, to 20 patients with asthma who ...
... lab cultures and mice, Johns Hopkins scientists have found that ... causes colon inflammation and increases activity of a gene ... is to expose the gut to hydrogen peroxide the ... cause DNA damage, contributing to the formation of colon tumors, ...
... role in kidney failure, and blocking the action of this ... according to researchers. "We believe these arginase inhibitors may ... the progression of, or even prevent the development of, end-stage ... Penn State College of Medicine. In the United States diabetes ...
Cached Medicine News:Health News:Rheumatoid arthritis patients have low expectations after knee replacement surgery 2Health News:Rheumatoid arthritis patients have low expectations after knee replacement surgery 3Health News:Studies Suggest Link Between Smog, Joint Disease 2Health News:Common Breast Cancer Gene Test May Be Flawed, Study Says 2Health News:Common Breast Cancer Gene Test May Be Flawed, Study Says 3Health News:ACAAI Annual Meeting abstracts: Improved outcomes for adults with allergies and asthma 2Health News:ACAAI Annual Meeting abstracts: Improved outcomes for adults with allergies and asthma 3Health News:ACAAI Annual Meeting abstracts: Improved outcomes for adults with allergies and asthma 4Health News:Common bacteria cause some colon tumors by altering peroxide-producing gene 2Health News:Research aims to prevent diabetic kidney failure 2
... CTi Wrist is a custom wrist orthotic designed to ... patient's maximum range-of-motion. , ,Indications: , Wrist ... fibrocartilage complex , Coles fracture - distal ... Partial tendon rupture , ORIF - Open ...
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
Provides secure fracture immobilization while allowing for full range of motion at elbow and wrist...
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
Medicine Products: