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Study in JAMA Shows Patients Treated With Abbott's XIENCE(TM) V Drug Eluting Stent Experience Better Outcomes Than Patients Treated With Market-Leading Drug Eluting Stent
Date:4/22/2008

equal to 30 days) or late (> 30 days), whether analyzed per protocol or by the Academic Research Consortium (ARC) definition. Rates of definite/probable late stent thrombosis at one year under the ARC definition were 0.5 percent for XIENCE V and 0.6 percent for TAXUS. The ARC definition of late stent thrombosis was developed to eliminate variability in the definitions across various drug eluting stent trials.

In addition, the reduction in in-segment late loss at eight months with XIENCE V compared to TAXUS was consistent across a variety of subgroups in the SPIRIT III trial; however, the SPIRIT III trial was underpowered to measure statistical differences in any of the subgroups.

The SPIRIT III nine-month results were previously reported in March 2007 at the American College of Cardiology's 56th Annual Scientific Session, and the one-year results were previously reported in October 2007 at the Transcatheter Cardiovascular Therapeutics scientific symposium. The SPIRIT III two-year results will be presented in mid-May at EuroPCR 2008 in Barcelona, Spain.

About the SPIRIT III Trial

SPIRIT III is a prospective, multi-center, randomized, single-blind, controlled clinical trial comparing XIENCE V to TAXUS in 1,002 patients (669 XIENCE V patients, 333 TAXUS patients) with either one or two de novo native coronary artery lesions. The trial was conducted across 65 academic and community-based centers in the United States between June 22, 2005 and March 15, 2006. The primary endpoint was in-segment late loss at eight months and the major secondary (co-primary) endpoint was TVF at nine months. An additional pre-specified secondary endpoint included MACE at nine months and one year.

About XIENCE V

The XIENCE V stent system utilizes everolimus, which has been shown to reduce tissue proliferation in the coronary vessels following stent implantation, and is based upon the highly deliverable and proven MULTI-LINK VISION(R) coronary stent p
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SOURCE Abbott
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