Navigation Links
Study examines new class of anticoagulants for VTE prevention and treatment
Date:12/11/2013

ANN ARBOR, Mich., Dec. 11, 2013 /PRNewswire-USNewswire/ --- The University of Michigan has been awarded $1.7 million to collaborate with GlycoMimetics, Inc., to study a new class of anticoagulants to help millions of Americans at risk or venous thromboembolic disease (VTE), a serious blood-clotting disorder.

The National Heart Lung and Blood Institute is supporting the three-year clinical trial of GMI-1271, an E-selectin antagonist that preliminary data shows prevents blood clot formation and reduces thrombus weight by 50-60 percent.

Co-principal investigators at the U-M are Suman Sood, M.D., a hematologist at the University of Michigan Comprehensive Cancer Center, and Thomas Wakefield, M.D., head of vascular surgery at the U-M Frankel Cardiovascular Center.

VTE, which can happen after a major operation, or severe illness such as heart attacks, stroke and some cancers, refers to both pulmonary embolism and deep vein thrombosis (DVT), blood clots that form in large veins of the legs. The clots become dangerous when they break loose and affect blood flow to the heart and lungs.

A mainstay of VTE prevention and treatment are anticoagulants that reduce blood clotting. But the medicines are associated with a significant risk of hemorrhage and for the most part do not decrease the inflammation that comes with VTE.

"The use of E-selection inhibition has a high therapeutic potential to decrease both thrombosis and its harmful inflammatory effects," says Sood.

GMI-1271 inhibits the cell-cell interactions that provide the scaffolding for blood clots to form. The compound is in the pipeline of drugs developed by GlycoMimetics, Inc., a clinical stage biotechnology company.

"We hypothesize that use of an E-selection inhibitor in patients with acute DVT, either alone or in combination with traditional anticoagulants, may lead to a greater thrombus resolution, higher rates of preserved valve competence, reduced pain and swelling and improved quality of life," says Wakefield.

Enrollment in the phase 1 clinical trial at the U-M is expected to begin in mid-2014 and to include healthy volunteers and those with calf level DVT.

On the Web:
University of Michigan Frankel Cardivascular Center www.umcvc.org
GlycoMimetics
, Inc. www.glycomimetics.com


'/>"/>
SOURCE University of Michigan Health System
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Otonomy Enrolls First Patient in Pivotal Phase 2b Study of OTO-104 in Menieres Disease
2. Avanir Pharmaceuticals Announces Results for Phase II PRIME Study
3. AbbVie Demonstrates 96 percent SVR(12) in its Phase III Study of Treatment-Experienced Patients with Genotype 1 Hepatitis C
4. New Study: Medicare Preferred Pharmacy Network Plans Offer Lower Average Premiums, Same Quality as Non-Preferred Network Plans
5. Upsher-Smith Debuts Positive Results From Global Phase 3 Study Evaluating USL255 (extended-release topiramate) In Epilepsy Patients With Refractory Partial-Onset Seizures
6. New Study Finds Targeted Treatment Can Significantly Reduce Relapse Risk In High-Risk Children With Acute Myeloid Leukemia
7. Heptares Initiates Clinical Study With First Selective Muscarinic M1 Receptor Agonist for Improving Cognition in Patients With Alzheimers Disease
8. Shire Reports Top-Line Results on OPUS-2, a Phase 3 Study Investigating the Use of Lifitegrast (5.0% Ophthalmic Solution) in Adults With Dry Eye Disease
9. Third Clinical Study Confirms Treatment Guided By GeneSight Psychiatric Pharmacogenomics Test
10. Study Confirms Efficacy of Innovative Therapies Quantum Negative Pressure Wound Therapy (NPWT) in Enhancing Wound Healing
11. Annual General Meeting Schedules, New Drug Applications, Positive Study Results, Conference Participations, and Secondary Offerings - Research Report on Mindray, AcelRx, Merrimack, ZELTIQ, and Clovis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... 2016   Click here for supplemental information ... DPLO), the nation,s largest independent specialty pharmacy, announced ... to acquire Valley Campus Pharmacy, Inc., doing business ... specialty pharmacy that provides individualized patient care, based ... In 2015, TNH generated approximately $400 million in ...
(Date:4/28/2016)...  While Abbott,s announced purchase of St. Jude ... and stent business, healthcare research firm Kalorama Information ... into patient monitoring.  Kalorama said that patient monitoring ... with double-digit growth expected the next 5 years, ... Patient Monitoring . Abbott Laboratories agreed to ...
(Date:4/28/2016)... 2016 Research and Markets has ... Products Market 2016-2020" report to their offering. ... The global plastic surgery products market is expected ... period 2016-2020. , ,The growing adoption of laser in ... of the market. Lasers are used to treat a ...
Breaking Medicine Technology:
(Date:4/28/2016)... ... , ... Head Over Heels Athletic Arts’ gymnast, Brooklyn Varize, has qualified to ... at the University of Montana on April 28-May 1. Varize will compete on Saturday ... order to qualify, Varize needed to place top seven all-around in her respective age ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... announces today the open availability of a new CDISC standard, Clinical Trial ... registering clinical trials. This innovative standard will make it possible to build ...
(Date:4/28/2016)... Los Angeles, CA (PRWEB) , ... April 28, 2016 , ... ... section on its website, cosmetictown.com . The forum section was recently revamped and ... about the latest surgical techniques in use across the country. , According to the ...
(Date:4/28/2016)... Beach, FL (PRWEB) , ... April 28, 2016 , ... ... the spring season. Smart pots are frequently used by professional organic farmers and nurseries ... growers to order their supply of fabric pots. Our goal is to offer wholesale ...
(Date:4/28/2016)... ... April 28, 2016 , ... In 2011, TIME magazine ... the emerging field of biomechatronics, technology that marries human physiology with electromechanics. He continues ... He is also the Founder of BionX , a leader in the field ...
Breaking Medicine News(10 mins):