Navigation Links
Study Unblinded: ZYTIGA® (abiraterone acetate) Plus Prednisone for Asymptomatic or Mildly Symptomatic Chemotherapy-Naive Patients with Metastatic Castration-Resistant Prostate Cancer
Date:3/8/2012

nical symptoms or signs suggestive of hepatotoxicity develop. Elevations of AST, ALT, or bilirubin from the patient's baseline should prompt more frequent monitoring. If at any time AST or ALT rise above five times the upper limit of normal (ULN) or the bilirubin rises above three times the ULN, interrupt ZYTIGA® treatment and closely monitor liver function.

Food Effect - ZYTIGA® must be taken on an empty stomach. Exposure of abiraterone increases up to 10-fold when abiraterone acetate is taken with meals. No food should be eaten for at least two hours before the dose of ZYTIGA® is taken and for at least one hour after the dose of ZYTIGA® is taken. Abiraterone Cmax and AUC0-infinity (exposure) were increased up to 17- and 10-fold higher, respectively, when a single dose of abiraterone acetate was administered with a meal compared to a fasted state.

Adverse Reactions - The most common adverse reactions (greater than or equal to 5%) are joint swelling or discomfort, hypokalemia, edema, muscle discomfort, hot flush, diarrhea, urinary tract infection, cough, hypertension, arrhythmia, urinary frequency, nocturia, dyspepsia, fractures and upper respiratory tract infection.

Drug Interactions - ZYTIGA® is an inhibitor of the hepatic drug-metabolizing enzyme CYP2D6. Avoid coadministration with CYP2D6 substrates that have a narrow therapeutic index. If an alternative cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate. Additionally, abiraterone is a substrate of CYP3A4 in vitro. Strong inhibitors and inducers of CYP3A4 should be avoided or used with caution.

Use in Specific Populations - The safety of ZYTIGA® in patients with baseline severe hepatic impairment has not been studied. These patients should not receive ZYTIGA®.

About Janssen Research & Development, LLC

Janssen Research & Development, LLC is headquartere
'/>"/>

SOURCE Janssen Research & Development, LLC
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
6. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
7. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
8. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
11. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/27/2014)... , 27 de octubre de 2014 /PRNewswire/ ... menudo conocida como ardor de estómago, es un ... mundo. [1] La elección de alimentos [2] ... un impacto en los síntomas de la GERD. ... ayudar a las personas a gestionar los síntomas ...
(Date:10/27/2014)... -- In the last few weeks, Ebola has gone from a localized ... a worldwide crisis when a traveler to United States ... nurses were infected. While much of the cable news ... technology, such as electronic health records (EHRs), to help find, combat, ... Healthcare Editor Alison Diana fills in those gaps by ...
(Date:10/27/2014)... Mass. , Oct. 27, 2014  OMNIlife science™, ... billion global hip and knee replacement device market, announced it ... replacement technology at the American Association of Hip and ... Dallas Hotel in Dallas, Texas ... Bronze corporate partner of the organization. ...
Breaking Medicine Technology:Trate los síntomas del reflujo gracias a la Food4GERD App 2Trate los síntomas del reflujo gracias a la Food4GERD App 3Trate los síntomas del reflujo gracias a la Food4GERD App 4EHRs in the Age of Ebola: Discuss on InformationWeek 2EHRs in the Age of Ebola: Discuss on InformationWeek 3OMNIlife science to Exhibit at American Association of Hip and Knee Surgeons 24th Annual Meeting in Dallas November 6-9 2OMNIlife science to Exhibit at American Association of Hip and Knee Surgeons 24th Annual Meeting in Dallas November 6-9 3
... Texas, Nov. 18, 2010 OCuSOFT, Inc., an ... to announce that ZYTAZE™ is now available in ... but are not limited to: Walgreens, CVS, Wal-Mart, ... In an early pilot study, ZYTAZE™ demonstrated marked ...
... FORD, Pa., Nov. 18, 2010 Endo Pharmaceuticals Holdings ... it priced $400 million aggregate principal amount of 7.00% ... of 99.10 percent in connection with its previously announced ... of the Company and will be guaranteed by certain ...
Cached Medicine Technology:Endo Pharmaceuticals Holdings Inc. Announces Pricing of Private Offering of Senior Notes 2
(Date:10/30/2014)... Diego, Calif. (PRWEB) October 30, 2014 ... longer mutually exclusive concepts in the medical-grade skin ... on the development of uniquely potent topical dermatological ... Health System ( http://www.RefinitySkinScience.com ) with patented COSMEDERM®-7 ... available glycolic acid concentrations (50% and 70%) and ...
(Date:10/30/2014)... 30, 2014 Paramount Rx, a full-service ... increasing efforts to help people save money through its ... increase for prescription drugs in the new health care ... resources to bridge the relationship between consumers, businesses and ... biggest challenges people face today with medical costs is ...
(Date:10/30/2014)... HealthDay Reporter , WEDNESDAY, Oct. ... have been identified that appear linked to autism spectrum ... they are on their way to discovering up to ... Autism spectrum disorders include a range of developmental ... behaviors. An estimated one in 68 U.S. children has ...
(Date:10/30/2014)... 30, 2014 Dr. Joseph Furlin MD, a ... for his practices; OB GYN in Melrose Park, IL ... This website contains important information about each of the care ... downloadable patient forms in English and Spanish. The navigation ... pages on the website provide Dr. Furlin’s patients with important ...
(Date:10/30/2014)... FL (PRWEB) October 30, 2014 ... Joint Commission Accredited teleradiology and specialty telemedicine solutions ... in addition to its existing teleradiology services at ... second opinion and expert telemedicine services, to the ... , As a result of this innovative partnership, ...
Breaking Medicine News(10 mins):Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 2Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 3Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 4Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Discovery of 100-Plus Genes Tied to Autism May Improve Treatments 2Health News:Discovery of 100-Plus Genes Tied to Autism May Improve Treatments 3Health News:Dr. Joseph Furlin Launches New Website with Information about Care Services 2Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 2Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 3
... Unrealistic, of,Entire White House Tenure, WASHINGTON, Feb. ... Bush Administration,s FY 2009 budget plan, the American,Health ... from the,standpoint of seniors, Medicare-financed nursing facility care, ... in states across,the nation -- which will surely ...
... Pairs of Shoes Symbolizing Deaths Caused by Tobacco,Use in ... the,statewide youth advocacy group H.O.T. (Helping Overcome Tobacco) will,gather ... Capitol Rotunda to,highlight the problem of tobacco use in ... on the steps of the Capitol, representing the,number of ...
... Sheela Sathyanarayana Fails to Disclose Political Activism, ... of a report from the American Academy of ... for Individual Freedom,(CFIF) today criticized the report as ... In addition to the report "conveniently" omitting,well-known scientific ...
... CINCINNATI A multi-institutional study led by researchers at ... insights and a model to help unravel the cause ... lead to disfigurement and in rare cases death by ... researchers said their findings also provide a means for ...
... have blood pressure under control, study finds , , MONDAY, Feb. ... and high blood pressure, black men are least likely to ... risk of life-threatening complications, a new study says. , Among ... men and women were less likely than white men and ...
... Off National Children,s Dental Health,Month With Outreach Events and ... is National,Children,s Dental Health Month. It,s sponsored each year ... families and policymakers,about the critical importance to children of ... in a row, the ADA opened the month with ...
Cached Medicine News:Health News:Bush Budget Represents 'Double Whammy' Hit on U.S. Seniors' Medicare-Financed Nursing Facility Care 2Health News:Conflict of Interest in American Academy of Pediatrics Report 2Health News:Conflict of Interest in American Academy of Pediatrics Report 3Health News:Model found to determine cause, possible treatment of nerve tumors 2Health News:Black Men Most at Risk for Kidney Disease Complications 2Health News:A Reminder to Parents: Early Dental Visits Essential to Children's Health 2Health News:A Reminder to Parents: Early Dental Visits Essential to Children's Health 3
3.5v Standard Ophthalmoscope Set with Convertible Handle and Soft Case. Our Standard Ophthalmoscope Sets feature high-quality instruments, handles, and cases....
High-quality eyecare from the preferred name in diagnostic instruments....
Our 3.5v Streak or Spot Retinoscope Sets feature instruments with the brightest light output in the industry, reliable handles, and convenient cases....
Testing for Strabismus (ocular misalignment) just became easier. By simply placing the StrabismoScope over the patient's eye, the examiner is able to observe the occluded eye directly, but the patien...
Medicine Products: