Navigation Links
Study Suggests Repurposing Anti-depressant Medication to Target Medulloblastoma
Date:8/24/2014

CINCINNATI, Aug. 24, 2014 /PRNewswire-USNewswire/ -- An international research team reports in Nature Medicine a novel molecular pathway that causes an aggressive form of medulloblastoma, and suggests repurposing an anti-depressant medication to target the new pathway may help combat one of the most common brain cancers in children.

The multi-institutional group, led by scientists at Cancer and Blood Diseases Institute (CBDI) at Cincinnati Children's Hospital Medical Center, publish their results in the journal's online edition on Aug. 24. The researchers suggest their laboratory findings in mouse models of the disease could lead to a more targeted and effective molecular therapy that would also reduce the harmful side effects of current treatments, which include chemotherapy, radiation or surgery.

"Although current treatments improve survival rates, patients suffer severe side effects and relapse tumors carry mutations that resist treatment," said lead investigator Q. Richard Lu, Ph.D., scientific director of the Brain Tumor Center, part of the CBDI at Cincinnati Children's. "This underscores an urgent need for alternative targeted therapies, and we have identified a potent tumor suppressor that could help a subset of patients with an aggressive form of medulloblastoma."

Using genetically-engineered mice to model human medulloblastoma, the authors identified a gene called GNAS that encodes a protein called Gsα. Gsα kicks off a signaling cascade that researchers found suppresses the initiation of an aggressive form of medulloblastoma driven by a protein called Sonic hedgehog – considered one of the most important molecules in tissue formation and development.

The scientists used an anti-depressant medication called Rolipram – approved for behavioral therapy for use in Europe and Japan – to treat
'/>"/>

SOURCE Cincinnati Children's Hospital Medical Center
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Study Finds Utilizing Integrated Medical and Pharmacy Data Improves Ability to Forecast Use of High-cost Specialty Treatments
2. Study Showed Patients Treated With The miraDry© System Experienced 82 Percent Sweat Reduction On Average
3. Asubio Initiates Landmark Clinical Study in Spinal Cord Injury
4. New Veridex Alliance Drives Study Of Circulating Tumor Cells In Men With Metastatic Prostate Cancer
5. Shingles Vaccine is Safe, According to New Study
6. Structural Trends to Profoundly Change Life Sciences Industry, Genpact Study Shows
7. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
8. Anthera Announces the Completion of Patient Dosing in Phase 2b PEARL-SC Study
9. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
10. Accuray Launches First Study to Compare CyberKnife® SBRT to Surgery and IMRT for Treatment of Early-Stage Prostate Cancer
11. Interim results of VITOBA™ (VImpaT® added to One Baseline AED) Study Presented at the 64th Annual Meeting of the American Academy of Neurology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... The western European automated endoscope reprocessor ... a replacement market with fewer new installations due ... partnerships are redefining competitive landscape in western ... details about revenue forecasts, unit shipments, market share ... country. The changing landscape makes it important to ...
(Date:9/22/2014)... -- Research and Markets  has announced the addition ... report to their offering. This newly ... up-to-date publication available covering the neurotechnology industry. The report ... and growth rates in four key segments of the ... forecasts the number of systems to be sold, worldwide ...
(Date:9/22/2014)... , Sept. 22, 2014 Children,s National ... Monday, Sept. 29 at 5 p.m. EDT for ... competition, in response to continued strong interest from ... each will be awarded to the winning presentations ... Innovation Symposium hosted by Children,s National in October. ...
Breaking Medicine Technology:Automated Endoscope Reprocessor Market Trends in Western Europe 2Automated Endoscope Reprocessor Market Trends in Western Europe 3The Market for Neurotechnology: 2014-2018 2Calling all medical innovators: Submit your pediatric medical device pitch for Children's National competition by Sept. 29 2Calling all medical innovators: Submit your pediatric medical device pitch for Children's National competition by Sept. 29 3
... , Increased vaccination ... gaps remain, others must join effort , DAVOS, Switzerland ... announced today that their foundation will commit $10 billion ... deliver vaccines for the world,s poorest countries. , (Photo: ...
... , , REDWOOD CITY, Calif. ... today announced financial results for its fiscal second quarter and six months ... call at 4:30 p.m. Eastern Time to discuss the financial ... quarter, as we continued to transition the sales model for our cardiac ...
Cached Medicine Technology:Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 2Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 3Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 4Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 5Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 6Cardica Announces Fiscal 2010 Second Quarter Financial Results 2Cardica Announces Fiscal 2010 Second Quarter Financial Results 3Cardica Announces Fiscal 2010 Second Quarter Financial Results 4Cardica Announces Fiscal 2010 Second Quarter Financial Results 5Cardica Announces Fiscal 2010 Second Quarter Financial Results 6Cardica Announces Fiscal 2010 Second Quarter Financial Results 7Cardica Announces Fiscal 2010 Second Quarter Financial Results 8Cardica Announces Fiscal 2010 Second Quarter Financial Results 9
(Date:9/23/2014)... Sandpoint, Idaho (PRWEB) September 23, 2014 ... GunSafes.com is now offering SecureIt Tactical products ... prices. SecureIt Tactical, Inc. holds a good name in ... The company stores only the finest products and now ... tactical gun safes such as the MilSpec Tactical Safe ...
(Date:9/22/2014)... Vida Cannabis Corp . is ... Agreement with Florida-based AltMed LLC . , ... and technical expertise. They’ll also pool business development ... markets. , "We’re deeply impressed with the level ... Cannabis team as they work toward building the most ...
(Date:9/22/2014)... Detroit MI (PRWEB) September 23, 2014 ... 3 organization dedicated to serving patients, caregivers and families ... of Philip M. Fortier of Detroit, MI to its ... disease of the brain and spinal cord, and is ... addition to resembling Parkinson’s disease (MSA Type P), MSA ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 Airbus Helicopters ... industry Monday for their efforts to improve safety and ... Award and the Program of the Year award, both ... Air Medical Transport Conference Annual Community Awards. , ... with the Jim Charlson Aviation Safety Award, given annually ...
(Date:9/22/2014)... United States District Judge Joseph ... mesh lawsuits ( http://www.meshinjurylawfirm.com/lawsuits/ ) filed against defendant ... pretrial matters, issued an order in the multidistrict ... Products Liability Litigation (United States District Court for ... 2:12-md-02326)—requiring that four member cases be ready for ...
Breaking Medicine News(10 mins):Health News:GunSafes.com Now Offers Secure Tactical Range of Gun Safes 2Health News:Vida Cannabis Allies with Florida Medical Cannabis Leader AltMed to Build Best-in-Class Expertise 2Health News:Philip Fortier appointed to Multiple System Atrophy Coalition Board of Directors 2Health News:Philip Fortier appointed to Multiple System Atrophy Coalition Board of Directors 3Health News:Airbus Helicopters Inc. Honors Leaders in Air Medical Industry 2Health News:Airbus Helicopters Inc. Honors Leaders in Air Medical Industry 3Health News:Federal Court Sets Trial Date for Boston Scientific Vaginal Mesh Cases in Florida, the Rottenstein Law Group LLP Reports 2
... U.S. Environmental,Protection Agency has given $97,204 to ... providers and women of child-bearing age on,environmental health ... grants nationwide. In Ohio, the grant will be ... woman,s potential exposure to environmental,risks., The EPA ...
... N.J., Feb. 4 NPS Pharmaceuticals,Inc. (Nasdaq: NPSP ... and chief operating officer, is scheduled to present at ... York on Monday, February,11, 2008 at 1:15 p.m. ET. ... a replay available approximately three hours after the,presentation has ...
... MONDAY, Feb. 4 (HealthDay News) -- Drug-coated stents are better ... research finds. , "There are two messages I would take ... professor of cardiology at Wake Forest University and lead author ... Journal of the American College of Cardiology. "The ...
... has,agreed to settle for $2.5 million, plus interest, ... program, the Justice Department,announced today. The settlement is ... Medical Center is currently in bankruptcy., The ... to Medicare patients in order to obtain enhanced,reimbursement ...
... ALTO, Calif., Feb. 4 Formerly conjoined twins,Yurelia ... at Stanford and are now home in Costa ... Children,s last Wednesday (30) and went,to Southern California ... sponsor the girls, trip. Today (4), they flew ...
... Those with poor balance, dementia, vision loss most in peril, ... -- Certain people are at high risk for accidental falls ... number of fall-related injuries and deaths in the United States, ... States, accidental falls result in 1.8 million emergency room visits ...
Cached Medicine News:Health News:Drug-Coated Stents Better Than Bare-Metal Ones in Complex Cases 2Health News:Drug-Coated Stents Better Than Bare-Metal Ones in Complex Cases 3Health News:Buyer of Bayonne Hospital to Pay U.S. $2.5 Million to Resolve Allegations of Medicare Fraud 2Health News:Formerly Conjoined Twins Leave Packard Children's Hospital; Heading Home to Costa Rica 2Health News:New Guideline Urges Screening for Fall Risk 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: