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Study Shows Whole-Cell Vaccine was More Effective than Acellular Vaccine During California Pertussis Outbreak
Date:5/19/2013

est means currently available to help protect this group against disease."

Studies demonstrate that whole-cell and acellular pertussis vaccines administered to infants trigger different immune responses that at least partially persist through the teenage years, but long-term clinical consequences of such differences have been unknown. The results of this study, the researchers said, suggest that variations in immune responses induced by primary immunization during infancy play a central role in protection from disease years later. Additionally, the study highlights the need for new pertussis vaccines that provide both an improved safety profile and long lasting immunity.

Additional authors on the study include Joan Bartlett , MPH, MPP, Bruce Fireman, MA, Ali Rowhani-Rahbar , MD, MPH, PhD, and Roger Baxter , MD, of  Kaiser Permanente Division of Research in Northern California.

This research was supported by funding from Kaiser Permanente.

About the Kaiser Permanente Vaccine Study Center
Founded in 1985, the Kaiser Permanente Vaccine Study Center began as a way of responding to numerous requests to use Kaiser Permanente's large population for vaccine efficacy studies. Key studies have focused on Haemophilus influenza, type B (Hib), chickenpox, pneumococcus, rotavirus and flu vaccines. The center operates 31 sites in Northern California and collaborates with Kaiser Permanente's Northwest, Hawaii and Colorado regions, as well as participates in several Centers for Disease Control and Prevention and National Institutes of Health studies. For more information, visit dor.kaiser.org/external/DORExternal/vsc/index.aspx.

About the Kaiser Permanente Division of Research
The Kaiser Permanente Division of Research conducts, publishes and
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