Navigation Links
Study Shows Vernakalant Hydrochloride is Effective in Conversion to Normal Heart Rhythm in Atrial Fibrillation Patients Following Cardiac Surgery
Date:11/7/2007

ents with AF/atrial flutter given vernakalant (45 percent) demonstrated conversion to SR within 90 minutes compared to patients given placebo (15 percent), p=.0002. In the subset of patients with AF at baseline, conversion was observed in 47 percent treated with vernakalant compared with 14 percent given placebo, p=.0001. Median time to conversion among vernakalant responders was 12 minutes and SR was maintained for patients with AF/atrial flutter for 24 hours in 60 percent and for seven days in 57 percent. Seventy-five percent of vernakalant responders required only one dose of drug. Vernakalant is not effective in atrial flutter.

The most common adverse events (AEs) in patients given vernakalant were AF (20 percent), nausea (6 percent), constipation (5 percent), weight increase (5 percent) and dyspnea (5 percent). Rates of serious AEs over the entire study were similar with placebo (11 percent) and vernakalant (9 percent). In the first 24 hours, only 2 patients (2 percent) given vernakalant experienced a serious AE (complete AV block and hypotension). There were no deaths or cases of torsade de pointes.

About Atrial Fibrillation

AF is an interruption of the normal sinus rhythm (arrhythmia) of the heart in which the atria, the two uppermost chambers of the heart, beat irregularly and at an extremely rapid rate(1). During AF, rapid and uncoordinated electrical discharges are generated by the heart's natural pacemaker (sinoatrial node) and other parts of the atria. This causes ineffective contractions of the atria and reduces the ability of the heart to pump blood through the body. Symptoms include dizziness, heart palpitations, weakness, shortness of breath and angina (chest pain)(1). The number of AF patients is expected to triple over the next 50 years due to the increased prevalence of risk factors including hypertension, obesity, diastolic dysfunction, inflammation, diabetes and sleep apnea(2).

About Astellas

Astellas Pharma US, Inc
'/>"/>

SOURCE Astellas Pharma US, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
6. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
7. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
8. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
11. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... This report analyzes the worldwide markets for Enteral Feeding Devices ... Pumps, Nasogastric Tubes, and Others. The report provides ... , Europe , Asia-Pacific ... of World. Annual estimates and forecasts are provided for the ... provided for these markets. The report profiles 38 ...
(Date:9/30/2014)... Mass. , Sept. 30, 2014  Hologic, Inc. ... Stephen MacMillan , Hologic,s President and Chief Executive Officer, ... Ceremony on October 1, the first day of Breast ... discuss the Company,s campaign focused on the important benefits ... approved by the FDA as clinically superior to traditional ...
(Date:9/30/2014)... , Sept. 30, 2014  Tasly Pharmaceuticals, ... to modernize medicine, announced today the launch of ... nutraceuticals developed to address men and women concerned ... and vibrant into old age while helping keep ... three condition-specific, whole-food and herb-based formulas, namely, ProHeart ...
Breaking Medicine Technology:Global Enteral Feeding Devices Industry 2Global Enteral Feeding Devices Industry 3Global Enteral Feeding Devices Industry 4Global Enteral Feeding Devices Industry 5Global Enteral Feeding Devices Industry 6Global Enteral Feeding Devices Industry 7Global Enteral Feeding Devices Industry 8Global Enteral Feeding Devices Industry 9Global Enteral Feeding Devices Industry 10Global Enteral Feeding Devices Industry 11Global Enteral Feeding Devices Industry 12Global Enteral Feeding Devices Industry 13Global Enteral Feeding Devices Industry 14Global Enteral Feeding Devices Industry 15Global Enteral Feeding Devices Industry 16Global Enteral Feeding Devices Industry 17Global Enteral Feeding Devices Industry 18Global Enteral Feeding Devices Industry 19Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 3
... 13 Accuray Incorporated (Nasdaq: ARAY ), a global ... management is scheduled to present at the Oppenheimer Healthcare Conference ... 9:40 a.m. ET (6:40 a.m. PT). , A live webcast ... Relations page of the Company,s Web site at ...
... a leading national supplier of advanced medical and aesthetic ... USA. Human Med AG of Germany, a leading ... Body-Jet®, has formed Human Med USA to partner with ... United States and North America. , "With the ...
Cached Medicine Technology:Accuray Incorporated to Present at 20th Annual Oppenheimer Healthcare Conference 2Eclipse Announces Partnership with Human Med USA, Manufacturers of Revolutionary Body-Jet(R) 2
(Date:10/1/2014)... Patients with increased inflammation, including those receiving cytokines ... of depression. For example, a 6-month treatment course ... infection causes depression in approximately 30% of patients. ... as fish oil, have a long list of ... disease and reducing triglyceride levels. These nutritional compounds ...
(Date:10/1/2014)... October 01, 2014 Insuranceragents.info has ... a good life insurance plan for vulnerable family members. ... vulnerable family members. Providers in the family should always ... cause financial hardships for the rest of the family. ... policies. Families can benefit more from temporary coverage or ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 ... networking and relationship-marketing firm, announced today the ... Executive® and Project of the Year Awards ... makers representing organizations in financial services, commercial, ... large-scale technology endeavors that address key issues ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Between 23 ... in the U.S., according to figures from the National ... Diseases Association (AARDA), and many of them have something ... of having undiagnosed celiac disease. Gluten Free Therapeutics, ... awareness of undiagnosed celiac disease by publishing a series ...
(Date:10/1/2014)... October 01, 2014 Scientists at the ... drugs that target immune system proteins has the power ... just posted details of the new study on their ... , Researchers in the UWA School of Pathology ... drugs to mice with mesothelioma with promising results. ...
Breaking Medicine News(10 mins):Health News:Omega-3 fatty acids may prevent some forms of depression 2Health News:Life Insurance for Families - Clients Can Compare Affordable Rates Online! 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:New Mesothelioma Study Says Mice Cured by Immuntherapy “Cocktail”, Reports Surviving Mesothelioma 2
... team of India-born medical researchers in the United States has ... fight against colon cancer.// ,The scientists from ... in mice by halting the activity of a single enzyme ... the toxic network of biochemical signals that promotes inflammation and ...
... of the greatest challenges facing researchers today, and recent research ... growing epidemic.// The World Health Organization has estimated that there ... of them nearly 300 million are obese. ,Scientists ... on the source of the problem – appetite, the main ...
... and Craig C. Mello of the US have won ... their discovery //of gene silencing by double-stranded RNA, it ... their discovery of RNA interference in awarding them the ... discovered "a fundamental mechanism for controlling the flow of ...
... A recent study has revealed that children in deep sleep ... by name and ordering them out of their bedrooms –although ... ,Dr. Gary Smith, one of the co-authors of ... showed that what works for adults doesn't always work for ...
... The deadly dengue viral enveloped 40 more people in the ... but the authorities// stated that the situation did not warrant ... to curb this menace. Our hospitals are well equipped to ... declare dengue as epidemic," said Health Minister Yoganand Shastri. ...
... With over 65 people dead and close to 100,000 people ... Chief Minister V.S. Achuthanandan Tuesday blamed experts for confusing the ... are confusing us because some say that it is not ... We will call an all party meeting and we have ...
Cached Medicine News:Health News:Brain behind the Brawn: Vital Molecule in the Brain Controls Appetite 2Health News:Two Americans Share 2006 Nobel Medicine Prize 2Health News:Mummy’s Voice More Effective than Smoke Alarm 2Health News:Dengue Outbreak in the Capital is not an Epidemic: Government 2
BB Watchmaker Forceps, Pakistan, 4.5" fine point....
The vertebral body replacement (VBR) is used for the anterior thoracic and lumbar spine. It is intended for use in the thoracic and lumbar spine to replace a collapsed, damaged, or unstable vertebral...
Vertigraft femoral shaft an large femoral cross-section designed primarily for use in lumbar corpectomy procedures. Freeze dried preservation....
... system provides anterior column support for single ... T1 to L5. The system consists of ... cages that are stacked to a desired ... Carbon fiber reinforced polymer material emulates the ...
Medicine Products: