Navigation Links
Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
Date:9/20/2007

llowed by continuous infusion of conivaptan 40 mg/day (n=29) or 80 mg/day (n=26) for four days.

The primary endpoint of the study was the change from baseline in serum sodium levels over the entire course of treatment (expressed as the "area under the curve," or AUC). Secondary endpoints included: time to reach a >/= 4 mEq/L increase in serum sodium levels; total time during which patients had a >/= 4 mEq/L increase in serum sodium levels; change in serum sodium levels at day four; and number of patients who achieved a >/= 6 mEq/L increase in serum sodium levels or a normal serum sodium concentration (>/= 135 mEq/L) over the course of the study.

Both doses of VAPRISOL significantly improved serum sodium levels relative to placebo, with a mean change in AUC of 490.9 (mEq/L)hr in the VAPRISOL 40 mg/day group, 716.6 (mEq/L)hr in the VAPRISOL 80 mg/day group, and 12.9 (mEq/L)hr in the placebo group (p=0.001). On average, VAPRISOL 40 mg/day and 80 mg/day produced a >/= 4 mEq/L increase in serum sodium levels within 23.7 hours and 23.4 hours, respectively. Over the course of the study, patients receiving VAPRISOL 40 mg/day, 80 mg/day, or placebo experienced increases in serum sodium of >/= 4 mEq/L for 53.2 hrs, 72.7 hrs, and 14.2 hrs, respectively (p<.001). At study's end, the mean change in serum sodium concentration was 6.3 mEq/L in patients who received VAPRISOL 40 mg/day and 9.4 mEq/L in those who received VAPRISOL 80 mg/day, compared with 0.8 mEq/L in patients who were given placebo (p<.001). Sixty-nine percent of VAPRISOL 40 mg/day patients (p<.001) and 88.5 percent of VAPRISOL 80 mg/day patients (p<.001) achieved a >/= 6 mEq/L increase in serum sodium levels or a normal serum sodium concentration (>/= 135 mEq/L) over the treatment period, compared with 20.7 percent of patients receiving placebo.

Several treatment-emergent adverse events were more common in VAPRISOL patients than in placebo patients, including injection site phlebitis, hypotension
'/>"/>

SOURCE Astellas Pharma US, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
10. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
11. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... More than 1,500 substance abuse prevention and ... Indianapolis Aug. 2-6 for Community ... Institute . The week-long training, held at the JW ... our nation,s biggest public health challenges – youth drug ... a one-of-a-kind intensive training opportunity, offering more than 70 ...
(Date:7/31/2015)... , July 31, 2015 According ... by Product (Moist Heat, Dry Heat, Ethylene Oxide, Filtration, E-beam, ... End User (Hospitals, Pharmaceuticals) - Global Forecast to 2020", published ... around USD 6.1 Billion by 2020, at a CAGR of ... 242 market data T ables and ...
(Date:7/31/2015)... and SAN DIEGO , ... its parent company Eisai Co., Ltd. (Headquarters: ... , "Eisai") and Halozyme Therapeutics, Inc. (Headquarters: ... Helen Torley , "NASDAQ: HALO") have signed a ... name: Halaven ® , "eribulin") in combination with Halozyme,s ...
Breaking Medicine Technology:Community Leaders From Across The Country Head To Indianapolis For CADCA 2015 Mid-Year Training Institute Aug. 2-6 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6
(Date:7/31/2015)... ... , ... Ticket Down is a reliable source of authentic Hamilton tickets ... refreshing show on Broadway, look no further than Hamilton. This American musical is critically ... Circle Award, Drama Desk Award, Lucille Lortel Award, and New York Drama Critics’ Award. ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to an article published ... if they could reach a consensus on the steps that need to be taken ... group reached 90 percent consensus on a series of steps that each surgeon must ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... negligence is now available online at ( http://www.lawline.com/cle/course/its-a-wonderful-life-if-you-receive-the-right-meds-a-discussion-of-pharmaceutical-negligence ). Mr. Brown’s ... rating from the nationwide audience. The course focused on the challenges ...
(Date:7/31/2015)... ... 31, 2015 , ... As part of their company mission, Dallas pet ... welfare organizations is essential to the longevity of their business. It is for ... of Professional Pet Sitters (NAPPS) annual Presents 4 Pets supply drive. Presents ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Transfinder, a ... 2015. , Total sales were up 16 percent year-over-year for the first six months ... Antonio Civitella said he expected Transfinder to beat last year’s record-revenue mark of $10.4 ...
Breaking Medicine News(10 mins):Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 3Health News:Re-Broadcast of Nationally Renowned Trial Attorney Jason T. Brown's Lecture on Pharmaceutical Negligence Now Available 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 4Health News:Transfinder Closes First Half of 2015 with Record Revenue 2
... perfect night,s sleepDALLAS, April 7 ... free-standing, patent pending kiosk that contains all of the ingredients ... breaks the mold for the industry standards of soft, medium ... individual,s sleep preference of side, back or stomach sleeper. The ...
... clinically relevant views of patient information from across disparate ... Corporation, whose Fusionfx solution suite aggregates patient ... relevant views of patient information, today announced that it ... The move is designed to serve and build ...
... Hospice of Northeast Florida , in collaboration with national, ... country to complete their advance healthcare directives -- an ... April 16, 2009 as ... in public awareness of the need for advance care ...
... /PRNewswire-Asia-FirstCall/ -- Mindray Medical,International Limited (NYSE: ... medical devices worldwide announced today that it will ... from April 18 to,April 21, 2009. , ... 50 devices from its three core product,segments: patient ...
... Emerging Technology Authorizations Among HighlightsSEATTLE, April 7 ... announced release of its 13th Edition of the ... to more than 1,000 clients in the US ... country,s eight largest managed care organizations, the annually ...
... integrate to provide customers with an end to end solution ... (eCTD), Non-eCTD Electronic Submissions and Paper Submissions to global regulatory ... ... and Marlborough, MA -- QUMAS, a leading provider of Regulatory ...
Cached Medicine News:Health News:Now Available Online, The Pillow Bar is the Right Mix of Luxury and Necessity 2Health News:Carefx Expands International Presence with New Office in London 2Health News:Carefx Expands International Presence with New Office in London 3Health News:Community Hospice Supports National Healthcare Decisions Day 2Health News:Community Hospice Supports National Healthcare Decisions Day 3Health News:Mindray Medical to Exhibit New Products at 61st China International Medical Equipment Fair 2Health News:Milliman Care Guidelines(R) 2009 Release Emphasizes Efficiency, Quality Solutions 2Health News:Milliman Care Guidelines(R) 2009 Release Emphasizes Efficiency, Quality Solutions 3Health News:QUMAS and Datafarm Integration for end-to-end Electronic Submissions 2
... is a quiet, compact, efficient vacuum source ... oil-free design and TEFLON®/ETFE coated vapor path ... and reduced maintenance. Unique features include a ... and a 1-liter post-pump solvent recovery vessel ...
... The revolutionary HydroTech vacuum pump is perfect ... applications requiring a continuous vacuum of greater ... The pump works very well with the ... quick disconnect fittings for 1/4 and 3/8 ...
Inquire...
... new QIAvac 24 Plus vacuum manifold allows processing of ... tedious loading and unloading of spin columns into and ... Plus offers: Time savings ... DNA, PCR products, and RNA Convenience ...
Medicine Products: