Navigation Links
Study Shows VAPRISOL(R) is Effective in Increasing Serum Sodium Levels and Well-Tolerated in Patients With Euvolemic or Hypervolemic Hyponatremia
Date:10/25/2007

0 mg/day and 40 mg/day. The 80 mg/day dose used in this study is not an approved dose.

Study Findings

The post-hoc pooled analysis is based on results from a randomized controlled trial (RCT) of 84 patients and an open-label study (OLS) of 251 patients, all with euvolemic or hypervolemic hyponatremia.

After infusion of a 20 mg loading dose or placebo, VAPRISOL was given in a continuous 4-day infusion of 40 or 80 mg/d in the RCT and 20 or 40 mg/d in the OLS. Follow-up time after the 4-day treatment included serum [Na+] assessments at day 11 for both groups as well as day 34 for the OLS group only. The primary endpoint of both studies was the change from baseline in serum [Na+] over the entire course of treatment (expressed as the area under the curve, or AUC). Secondary endpoints included: time to reach a greater than or equal to 4 mEq/L increase in serum [Na+]; total time during which patients had a greater than or equal to 4 mEq/L increase in serum [Na+]; change in serum [Na+] at day four; and number of patients who achieved a greater than or equal to 6 mEq/L increase in serum [Na+] or a normal serum [Na+] (greater than or equal to 135 mEq/L) over the course of the study.

Across both studies, patients receiving VAPRISOL showed significant increases in serum [Na+] starting on day one of treatment, with a sustained increase in serum [Na+] one to four weeks after the completion of the studies. In each VAPRISOL dosing group, mean time to a confirmed greater than or equal to 4-mEq/L increase was ~24 hours and the increase was maintained above baseline for most of the treatment period. By day four, VAPRISOL increased serum [Na+] above baseline (mean) from 6.8 to 9.7 mEq/L across the studies. Most VAPRISOL-treated patients achieved a confirmed greater than or equal to 6-mEq/L increase in serum [Na+] or normal serum [Na+] (69 to 88.5 percent in the RCT and 70.3 to 72 percent in the OLS).

In the RCT, VAPRISOL was significantly more effective th
'/>"/>

SOURCE Astellas Pharma US, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
10. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
11. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)...  Today, in final recognition of the Centers for ... 1-800 Contacts is sharing how to keep lens cases ... who do not properly care for their lens cases ... Most contact lens wearers understand the importance ... case is sometimes overlooked.  When proper steps to clean ...
(Date:8/28/2015)... 28, 2015 Research ... addition of the "Investigation Report on China,s ... Developed by Pharmacia & Upjohn in ... which effectively reduces intraocular pressure. As the first ... the trade name of Xalatan) entered ...
(Date:8/28/2015)... 28, 2015 Perrigo Company plc ("Perrigo") (NYSE: ... N.V. ("Mylan") (NASDAQ: MYL ) shareholder vote regarding ... "Our views of Mylan,s offer to Perrigo shareholders have ... our Board,s careful reflection of the value available to ... choices that Mylan has allowed its shareholders to consider," ...
Breaking Medicine Technology:1-800 Contacts Shares Tips on How to Clean Lens Cases 2China Latanoprost Market Investigation Report 2015-2019 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5
... N.J., Feb. 15, 2011 Pacira Pharmaceuticals, Inc., ... pharmaceutical company, today announced that additional safety data ... of EXPAREL™ (bupivacaine extended-release liposome injection) in bunionectomy. ... and significantly improved efficacy in pain reduction compared ...
... HILLS, Ill., Feb. 15, 2011 Genus Oncology, LLC, a ... cancer, announced it has successfully filed an Investigational New Drug ... and has dosed the first patient in a Phase I ... solid tumors. "We are excited to enter this ...
Cached Medicine Technology:Pacira Pharmaceuticals Highlights Additional Safety Data on EXPAREL™ for Postsurgical Pain Relief at 2011 American Academy of Orthopaedic Surgeons Annual Meeting 2Pacira Pharmaceuticals Highlights Additional Safety Data on EXPAREL™ for Postsurgical Pain Relief at 2011 American Academy of Orthopaedic Surgeons Annual Meeting 3Pacira Pharmaceuticals Highlights Additional Safety Data on EXPAREL™ for Postsurgical Pain Relief at 2011 American Academy of Orthopaedic Surgeons Annual Meeting 4Pacira Pharmaceuticals Highlights Additional Safety Data on EXPAREL™ for Postsurgical Pain Relief at 2011 American Academy of Orthopaedic Surgeons Annual Meeting 5Genus Oncology, LLC Announces Initiation of Phase I Trial of GO-203-2c in Patients With Solid Tumors 2Genus Oncology, LLC Announces Initiation of Phase I Trial of GO-203-2c in Patients With Solid Tumors 3
(Date:8/31/2015)... ... , ... On Saturday, May 30th, 2015, Best Drug Rehabilitation sponsored a benefit ... IL. The purpose behind this concert was to raise money for music education programs ... Rehabilitation’s sponsorship of “Music with a Mission” helped with a portion of the cost ...
(Date:8/31/2015)... , ... August 31, 2015 , ... ... e-Spirit to future-proof its content management system (CMS) and make website updates quicker ... Sports in making the websites of the Bundesliga (the German equivalent of the ...
(Date:8/31/2015)... Pittsburgh, PA (PRWEB) , ... August 31, 2015 , ... ... their ears,” said an inventor, from Hagerhill, Ky. “I thought there could be a ... Cannula Ear Protector. , The Nasal Cannula Ear Protector offers a more secure way ...
(Date:8/31/2015)... YORK (PRWEB) , ... August 31, 2015 , ... Move ... anti-aging products for men and barbershops are scrambling to meet it. , Reports published ... information for hairstyles and haircare. But the data also reflects that men are getting ...
(Date:8/31/2015)... Tennessee (PRWEB) , ... August ... ... of Lifestyle Medicine (ACLM), the nation’s medical professional association for physicians and ... in conjunction with the Lifestyle Medicine Foundation, announced today the establishment of ...
Breaking Medicine News(10 mins):Health News:2015 "Music With A Mission" Sponsor Best Drug Rehabilitation Releases Artist Compilation Video 2Health News:2015 "Music With A Mission" Sponsor Best Drug Rehabilitation Releases Artist Compilation Video 3Health News:On the Ball with FirstSpirit: German Soccer League (DFL Digital Sports) Opts for e-Spirit’s CMS 2Health News:InventHelp® Inventor Designs Nasal Cannula Ear Protector (AVZ-1217) 2Health News:MENAJI Anti-Aging Eraser a New Sure-Fire Add-On Product for Barbershops 2Health News:MENAJI Anti-Aging Eraser a New Sure-Fire Add-On Product for Barbershops 3Health News:Nominations Sought for Awards Recognizing Exemplary Contribution to the Field of Lifestyle Medicine 2Health News:Nominations Sought for Awards Recognizing Exemplary Contribution to the Field of Lifestyle Medicine 3
... and his team from Southampton General Hospital, studied the ... research work is aimed at studying the environmental risk ... to metal fume. ,Researchers found that the ... compared to the normal persons and an absence of ...
... has a profound effect on your health status. Confirming ... Massachusetts// and Pennsylvania which shows that race/ethnicity is a ... HAART (highly active antiretroviral therapy). , ,The study ... AIDS Clinical Trial Group studies. The main thrust was ...
... Pakistan appears to be in serious trouble with regard to ... country, bringing to a halt, an eight-year-old health program for ... the Lahore-based // NGO Vision that operates the Nayab Health ... and transgenders. ,Helped by Britain's Naz Foundation International, ...
... bowel movements, abdominal pain, and the Irritable Bowel Syndrome (IBS) ... China and India. Prof Jianping Liu, lead review author, said ... that some of the traditional medicines did improve the global ... were conducted on a small scale, so it is reported ...
... Unhappy marriages are harmful to the self-esteem and health of ... to higher levels of psychological distress when compared to those ... as many as 1,150 people in unhappy // marriages ... of sociology, human development and family studies, and demography said ...
... fertility predictor test, which enables women to find out ... This will be particularly useful to women who prefer ... for child bearing is// reported to be the twenties ... Sheffield University. But the pressure of modern life is ...
Cached Medicine News:Health News:Pakistani Gays Land Themselves In Trouble 2
Store microscope slides with ease, speed, efficiency....
... drawers for just about everything imaginable that might ... Each box is designed for long term storage ... of wood over metal systems is overlooked, while ... subtle kind of desiccator and insulator, providing an ...
A prepared Microscope Slide Cataloging and Storage System....
... Our moisture resistant, plastic covered ... high, each supporting up to 500 ... weight. Each box accommodates 2000 slides ... your varied storage requirements. Come unassembled ...
Medicine Products: