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Study Shows Use of AdvanDx's PNA FISH(TM) Test was Associated with an 82% Reduction in Intensive Care Unit Mortality Rates from Staphylococcus aureus Bloodstream Infections
Date:7/15/2008

the identified bacteria were reported directly to the treating clinicians whereas for patients in the Usual Care group, data were entered into the hospital's laboratory information system as usual. Medical records of enrolled patients were analyzed for demographics, comorbid conditions, location within the hospital, antimicrobial use, length of hospitalization, mortality, and other factors to understand the impact of the rapid PNA FISH results on patient care and outcomes. Significant comparison results for the two groups are listed below.

Comparison of Data for Notification of PNA FISH (NPF) group vs. Usual Care (UC) group

-- Total of 202 patients enrolled in study; 101 in NPF group vs. 101 in UC group

-- 61 patients with S. aureus; 32 in NPF group vs. 29 in UC group

-- 141 patient with CoNS; 69 in NPF vs. 72 in UC group

-- 44 patients in ICU vs. 158 in non-ICU

-- 53% reduction in overall mortality; 8 deaths in NPF group vs. 17 deaths in UC group

-- 80% reduction in mortality rate for intensive care unit (ICU) patients; 10% (2 deaths) for NPF group vs. 48% (11 deaths) for UC group

-- 82% reduction in mortality rate for ICU patients with S. aureus; 10% for NPF group vs. 56% for UC group

-- 67% reduction in median antibiotic use after notification of results; median of 1 day for NPF group vs. 3 days for UC group

-- 100% reduction in median antibiotic use for CoNS patients after notification of; 0 days for NPF group vs. 2.5 days for UC group

-- Trend toward $19,441 reduction in median hospital charges; $72,932 median charges for NPF group vs. $92,373 for UC group

"Rapid delivery of PNA FISH data from the laboratory to treating clinicians was associated with reduced mortality in ICU patients," said lead author Shmuel Shoham, M.D., Section of Infectious Diseases and Director of Transplant Infectious Diseases at Washington Hospital Center. "There was also a trend toward reduced length of
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SOURCE AdvanDx
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