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Study Shows Use of AdvanDx's PNA FISH(TM) Test was Associated with an 82% Reduction in Intensive Care Unit Mortality Rates from Staphylococcus aureus Bloodstream Infections
Date:7/15/2008

WOBURN, Mass., July 15 /PRNewswire/ -- AdvanDx today announced that a new study shows use of AdvanDx's PNA FISH(TM) test was associated with an 82% reduction in mortality rates from S. aureus bloodstream infections in the intensive care unit (ICU), a 53% reduction in overall mortality from staphylococcal bloodstream infections, and a significant reduction in antibiotic use. The study, published in the latest issue of the Journal of Therapeutics and Clinical Risk Management, the study was undertaken by clinicians in the Section of Infectious Diseases at Washington Hospital Center (WHC) in Washington, D.C.(1)

Bloodstream infections due to Staphylococcus bacteria are a leading cause of hospital-acquired infection mortality. The infection is initially diagnosed when a culture of a patient's blood turns positive with Gram-positive cocci in clusters (GPCC), indicative of staphylococci. Because conventional laboratory identification methods can take 48 hours or longer, treating clinicians can't determine whether the blood culture was positive due to true infection, requiring aggressive antibiotic therapy, or due to blood culture contamination with Coagulase-Negative Staphylococci (CoNS), a group of common skin bacteria, that don't require antibiotic therapy. As a result, patients with true infections are at times undertreated whereas patients with contaminated blood cultures are often unnecessarily treated with antibiotics. PNA FISH provides rapid, molecular identification of S. aureus and CoNS directly from positive blood cultures in hours instead of days. The test enables laboratories to provide fast results and help clinicians guide early and effective therapy for patients with bloodstream infections.

During the WHC study period, 202 patients with positive blood cultures containing GPCC were enrolled and blindly randomized into a "Notification" group or a "Usual Care" group. For patients in the Notification group, PNA FISH results and information on
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