Navigation Links
Study Shows That Roche's Investigational Drug for Alzheimer's Disease Removes Amyloid Plaques From the Brain
Date:10/10/2011

s in patients' brains about 15 years prior to the onset of dementia, ongoing and future clinical studies with gantenerumab will focus on Alzheimer's disease in the early or prodromal phase. It is hoped that early diagnosis and intervention, before significant damage to nerve cells has occurred, will offer optimal benefit to patients.

About the study

The effect of up to six months of treatment with gantenerumab at two different doses or placebo on brain amyloid was measured in 16 patients with mild to moderate Alzheimer's disease using positron emission tomography (PET) and the radiotracer 11C-Pittsburgh Compound B. In addition, Alzheimer's disease brain slices from an independent patient sample were incubated with gantenerumab at increasing concentrations and with human microglia in an ex vivo phagocytosis assay.

The next step will be to investigate whether removal of brain amyloid translates into clinical benefit for patients at doses of gantenerumab that reduce brain amyloid and are well tolerated, with a favorable safety profile.

This is the objective of the SCarlet RoAD trial, which is set to investigate the efficacy and safety of gantenerumab in patients in the early or prodromal stage of Alzheimer's disease. Early or prodromal Alzheimer's disease is a condition in which a person's memory loss is worse than can be expected by the normal ageing process alone, even though their ability to get on with daily activities is not affected to such an extent that they would be diagnosed with dementia.

The SCarlet RoAD study is currently recruiting 360 patients in 15 countries and will look at the effects that gantenerumab has on participants' ability to remember information, to solve problems and to go about day-to-day activities. For more information: http://www.scarletroadstudy.com/  

About gantenerumab (RG1450)

Gantenerumab is an investigational
'/>"/>

SOURCE Roche
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Hernia Publishes a Unique Three Year Pre-Clinical Study of absorbable TIGR® Matrix Surgical Mesh Versus a Permanent Mesh
2. Hologic Announces Six-year Follow-up Results from the MammoSite Targeted Breast Irradiation Registry Study
3. Bioness Inc. Announces Completion of Enrollment in Its FASTEST L300 Study
4. FDA CONSUMER HEALTH INFORMATION -- Foreign Exporters Study Food Safety Law
5. Telik Announces Publication in the Journal Cancer of a Phase 2 Randomized Multicenter Study of Two Extended Dosing Schedules of Oral Ezatiostat in Low to Intermediate-1 Risk Myelodysplastic Syndrome
6. Additional Analysis from Two-Year Sequel Study of QNEXA Featured at The 2011 Annual Scientific Meeting of The Obesity Society
7. Study by Ocala Oncology/The US Oncology Network Shows Use of Bevacizumab Beyond Progression in Metastatic Colorectal Cancer Patients Improves Overall Survival
8. Adamas Pharmaceuticals Initiates a Phase 2/3 Clinical Study of ADS-5102 for Parkinsons Disease
9. Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients
10. To Succeed in Crowded Market, Diabetes Manufacturers Beginning Key Launch Tactics Earlier, Study Says
11. Swype Cold & Flu Shield Significantly Reduces Occurrence of Colds in Clinical Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... SOUTH PLAINFIELD, N.J. , Nov. 21, 2014  PTC ... announce that the 2014 Legend of Technology Award for Vision, ... Peltz , Ph.D., Chief Executive Officer. This award recognizes an ... industry in New Jersey for several ... Legend of Technology Award," stated Stuart Peltz , Ph.D., ...
(Date:11/21/2014)... MONTREAL , Nov. 21, 2014 /PRNewswire/ ... that the European Medicines Agency (EMA) has ... the company,s lead product candidate, for the ... is a rare, severely disabling genetic disease ... tissue swelling (flare-ups) and new abnormal bone ...
(Date:11/21/2014)... 20, 2014  Edwards Lifesciences Corporation (NYSE: ... heart valves and hemodynamic monitoring, announced today that it ... support a strong launch of Edwards Lifesciences Foundation,s new ... improve the global communities where its employees live and ... giving will exceed $8 million, including more than $7 ...
Breaking Medicine Technology:PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 3Clementia Pharmaceuticals Receives EMA Orphan Medicinal Product Designation for Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva 2Clementia Pharmaceuticals Receives EMA Orphan Medicinal Product Designation for Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva 3Edwards Lifesciences Increases Charitable Giving In 2014 To Support Launch Of Every Heartbeat Matters 2
... 1, 2011 Cherokee Uniforms, a leading provider of medical ... its annual Inspired Comfort Award . The award provides ... above and beyond their call of duty to make a ... its inception in 2003, more than 9,000 healthcare professionals have ...
... Source Precision Medicine, Inc., dba SourceMDx ("SourceMDx") has assigned ... of the firm Finn, Warnke & Gayton, LLP to be ... Source MDx® is an industry leader in developing simple blood ... cancer by measuring specific RNA transcripts in blood. RNA is ...
Cached Medicine Technology:Cherokee Inspired Comfort Award Calls for Healthcare Professional Nominations 2Cherokee Inspired Comfort Award Calls for Healthcare Professional Nominations 3Source Precision Medicine, Inc., dba SourceMDx Assigns All Its Assets to Joseph F. Finn, Jr., C.P.A. of the firm of Finn, Warnke & Gayton, LLP 2
(Date:11/22/2014)... 2014 Domestic farmgate milk and ... 2009-10, due to a fall in demand for ... products amid the global financial crisis. However, these ... Australian dairy manufacturers on the international scene. Strong ... supply growth, primarily due to supply constraints in ...
(Date:11/22/2014)... New York, New York (PRWEB) November 22, 2014 ... been filed on behalf of patients who allegedly developed ... move forward in the federal multidistrict litigation now underway ... Liebhard LLP reports. According to court documents, the litigation ... at 10:00 a.m. The Court has directed Lead Counsel ...
(Date:11/22/2014)... November 22, 2014 Recently, UWDress.com is ... wedding guest dresses . In addition, the company has ... , As a leading online supplier of wedding ... beautiful outfits. The unusual best wedding guest gowns are ... the amazing designs, this new selection is famous for ...
(Date:11/22/2014)... November 22, 2014 Sandbridge Capital, ... investments in the consumer brand sector, acquired a ... will be used to help fund BackJoy’s global ... rollout, particularly its proprietary apparel and footwear lines. ... BackJoy’s Board of Directors. , BackJoy is a ...
(Date:11/22/2014)... 2014 “Greenfield Naturals” was featured on ... , which features the latest and coolest technology products ... reporter for NewsWatch, conducted the product review and shared ... of your water. , From pollution to hazardous substances ... everything is done to remove these chemicals, especially in ...
Breaking Medicine News(10 mins):Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 3Health News:Best Wedding Guest dresses Introduced by UWDress.com 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 3Health News:An Easy Home Solution to Get Better Tasting Water was Featured on NewsWatch Television on October 30, 2014 2
... Nov. 19 2009 has been a monumental year ... "moneyvation," from QUITPLAN Services, QuitCash Challenge, helped the 31-year-old ... win The Challenge. Nearly 2,000 Minnesotans, including Doug, attempted ... to win the $5,000 grand prize. , On Thursday, ...
... , Official Statement by Teamsters General President Jim ... President Jim Hoffa issued the following statement today about the ... higher-cost health plans that will mean a huge middle-class tax ... that would impose an excise tax on insurers for higher-cost ...
... , FAIRFIELD, N.J., Nov. 19 Monogram Energy, Inc. ... completed the acquisition of Triad Therapeutics, Inc. ("Triad"), which ... the terms of the Stock Purchase and Recapitalization Agreement, ... of Triad in exchange for approximately 95% ownership to ...
... who directs the University of Southern California Center ... effort to evaluate robots as exercise coaches for adults ... elderly. The effort, entitled "Robot Motivator: Towards Adaptive ... influence of virtual social characters on people,s motivation to ...
... , New Video Educates Kids on How to Prevent ... learn the five things that they can do to prevent the ... a new music video released today by the Department of Health. ... the simple ways to prevent H1N1 flu in a manner that ...
... WASHINGTON, Nov. 19 Now that a bill has been ... of the Democratic Caucus to vote to allow debate to ... promise of quality, affordable health care for all. , "Majority ... forward," said USAction Program Director Alan Charney. "Now it,s time ...
Cached Medicine News:Health News:First-Time Father-to-Be Quits Smoking, Wins $5,000 in The QuitCash Challenge(TM) 2Health News:First-Time Father-to-Be Quits Smoking, Wins $5,000 in The QuitCash Challenge(TM) 3Health News:Monogram Energy, Inc. Acquires Triad Therapeutics, Inc. 2Health News:Pennsylvania Department of Health Releases H1N1 Flu Prevention Music Video 2Health News:60 Votes: Democratic Caucus Must Move Forward With Promise of Quality, Affordable Health Care for All With a Public Insurance Option 2
The ENDO MINI-RETRACT™ 5 mm instrument has application in a variety of gynecologic, abdominal, urologic, thoracic and endoscopic procedures for temporary retraction of tissue and small tubular ...
... PADDLE RETRACT™ 12 mm instrument has application ... colorectal and other endoscopic procedures for retracting ... liver. , ,The ENDO PADDLE RETRACT™ ... the distal end of the instrument and ...
... Featured Products are kept ... and are offered as ... regular or extra long ... with insulation, flush ports, ...
... the widest offering of single-use instruments on the ... 43cm lengths for Bariatric Surgery. , Dual ... insulation covers the pivot points to reduce the ... 4mm universal cord, which eliminates gapping at connection ...
Medicine Products: