Navigation Links
Study Shows That Roche's Investigational Drug for Alzheimer's Disease Removes Amyloid Plaques From the Brain
Date:10/10/2011

s in patients' brains about 15 years prior to the onset of dementia, ongoing and future clinical studies with gantenerumab will focus on Alzheimer's disease in the early or prodromal phase. It is hoped that early diagnosis and intervention, before significant damage to nerve cells has occurred, will offer optimal benefit to patients.

About the study

The effect of up to six months of treatment with gantenerumab at two different doses or placebo on brain amyloid was measured in 16 patients with mild to moderate Alzheimer's disease using positron emission tomography (PET) and the radiotracer 11C-Pittsburgh Compound B. In addition, Alzheimer's disease brain slices from an independent patient sample were incubated with gantenerumab at increasing concentrations and with human microglia in an ex vivo phagocytosis assay.

The next step will be to investigate whether removal of brain amyloid translates into clinical benefit for patients at doses of gantenerumab that reduce brain amyloid and are well tolerated, with a favorable safety profile.

This is the objective of the SCarlet RoAD trial, which is set to investigate the efficacy and safety of gantenerumab in patients in the early or prodromal stage of Alzheimer's disease. Early or prodromal Alzheimer's disease is a condition in which a person's memory loss is worse than can be expected by the normal ageing process alone, even though their ability to get on with daily activities is not affected to such an extent that they would be diagnosed with dementia.

The SCarlet RoAD study is currently recruiting 360 patients in 15 countries and will look at the effects that gantenerumab has on participants' ability to remember information, to solve problems and to go about day-to-day activities. For more information: http://www.scarletroadstudy.com/  

About gantenerumab (RG1450)

Gantenerumab is an investigational
'/>"/>

SOURCE Roche
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Hernia Publishes a Unique Three Year Pre-Clinical Study of absorbable TIGR® Matrix Surgical Mesh Versus a Permanent Mesh
2. Hologic Announces Six-year Follow-up Results from the MammoSite Targeted Breast Irradiation Registry Study
3. Bioness Inc. Announces Completion of Enrollment in Its FASTEST L300 Study
4. FDA CONSUMER HEALTH INFORMATION -- Foreign Exporters Study Food Safety Law
5. Telik Announces Publication in the Journal Cancer of a Phase 2 Randomized Multicenter Study of Two Extended Dosing Schedules of Oral Ezatiostat in Low to Intermediate-1 Risk Myelodysplastic Syndrome
6. Additional Analysis from Two-Year Sequel Study of QNEXA Featured at The 2011 Annual Scientific Meeting of The Obesity Society
7. Study by Ocala Oncology/The US Oncology Network Shows Use of Bevacizumab Beyond Progression in Metastatic Colorectal Cancer Patients Improves Overall Survival
8. Adamas Pharmaceuticals Initiates a Phase 2/3 Clinical Study of ADS-5102 for Parkinsons Disease
9. Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients
10. To Succeed in Crowded Market, Diabetes Manufacturers Beginning Key Launch Tactics Earlier, Study Says
11. Swype Cold & Flu Shield Significantly Reduces Occurrence of Colds in Clinical Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com ... report is available in its catalogue: ... Application and Approval of Imported Medical ... (2014 Edition) ... Now, Chinese regulations on medical devices ...
(Date:8/27/2014)... Aug. 27, 2014  CVS Caremark (NYSE: ... new clinical affiliation with MedStar Health, a leading health ... and the Washington, DC ... health care services for patients. Through this clinical affiliation, ... clinical support, medication counseling, chronic disease monitoring and wellness ...
(Date:8/27/2014)... THOUSAND OAKS, Calif. , Aug. 27, 2014 /PRNewswire/ ... the U.S. Food and Drug Administration (FDA) has granted ... chronic heart failure (HF). Ivabradine is an oral drug ... ("funny" current) in the sinoatrial node, the body,s cardiac ... rate without negative effects on myocardial contractility or ventricular ...
Breaking Medicine Technology:Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 2Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 3Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 4Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 5Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 6Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 7Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 8Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 9Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 10CVS Caremark Announces New Clinical Affiliation with MedStar Health 2CVS Caremark Announces New Clinical Affiliation with MedStar Health 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 2FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 4FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 5FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 6FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 7
... Generex Biotechnology Corporation (Nasdaq: GNBT ; ... diseases through the inner lining of the mouth, announced ... Licensing & Distribution Agreement with PMG S.A. ( www.pmgpharma.com ... Generex Oral-lyn™, the Company,s proprietary buccal insulin spray product, ...
... Corporation, a privately-held biotechnology company focused on developing a ... announced that Quinton Oswald has joined the company as ... significant commercial experience and management expertise to the CEO ... the Vice President & Business Unit Head for the ...
Cached Medicine Technology:Generex Announces Distribution Agreement for Generex Oral-lyn™ in Chile 2Generex Announces Distribution Agreement for Generex Oral-lyn™ in Chile 3Quinton Oswald Named Chief Executive Officer of SARcode Corporation 2Quinton Oswald Named Chief Executive Officer of SARcode Corporation 3
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 MarijuanaDoctors.com ... California physician, James Patel M.D. of Livermore, California. As ... best and most qualified physicians, and in accordance with ... our patients to Dr. Patel’s practice. , Initially finding ... a young age, Dr. Patel was shaped by his ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 The need for ... over the past few years. The new location - 4700 ... higher quality and larger office space than TLC had in ... , “We are pleased about our new location because it ... our suite will be double in size compared to the ...
(Date:8/27/2014)... Author and orthopedic surgeon William H. Simon’s ... thrilling adventures of sharp and witty Dr. Ham ... up for a new marketing push in the second ... , “Prescription: Murder” follows the adventures of Ham Marks, ... attempts and thwarting criminals. In the first novella, “Over ...
(Date:8/27/2014)... an innovative company that provides many kinds of top quality ... are now offered on its website. In addition, the firm ... that place an order for its newly released items can ... , The company’s senior spokesman was excited to talk ... and old customers can buy cheap bamboo panels on our ...
(Date:8/27/2014)... National Resident Matching Program International (NRMPI) ... Education in Europe (AMEE) Conference being held at the ... September 3, 2014. As an exhibitor, NRMPI will ... share the benefits of its matching services, and discuss ... countries throughout the world. , “Exhibiting at ...
Breaking Medicine News(10 mins):Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 2Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 3Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 4Health News:William H. Simon Launches New Marketing Campaign for Book 2Health News:BambooIndustry.com: Cheap Bamboo Panels for Clients Worldwide Offered Online 2Health News:National Resident Matching Program International (NRMPI) to Exhibit at the 2014 AMEE Conference 2
... CRANSTON, R.I., Nov. 27 A new, ... manufacturers (OEMs) on choosing the,right electronics manufacturing ... available free to download at, http://www.federalelec.com/medicalpaper ., ... need for consistent quality and,conformance to product ...
... 27, 2007, 4:00 p.m. E.S.T. - Positron emission tomography ... need for more accurate staging of lung cancer and ... published online today in Journal of National Cancer Institute. ... Cancer Disease Site Group of Cancer Care Ontarios Program ...
... Nov. 27 A new study that shows young ... for men has leveled off offers,strong evidence that preventive ... war on cardiovascular disease, said Christopher T. Fey, the,chairman ... released study published in Journal of the American College ...
... therapies, experts say , , TUESDAY, Nov. 27 (HealthDay News) ... doctors predict which postmenopausal women are likely to sustain ... algorithm includes 11 different factors -- such as age ... of different ethnic backgrounds. , "Knowing the 5-year ...
... Risk Elevated in Male BRCA Mutation Carriers , Men with ... of breast cancer than the general population. , Male breast cancer ... the U.S., and it is most common in men with a ... who carry mutations in the BRCA2 gene have a greater risk ...
... R.I. [Brown University] Heavy smoking and drinking are ... human papillomavirus type 16 (HPV16), a common strain of ... for head and neck cancer, which affects about 500,000 ... however, shows that alcohol and tobacco use doesnt further ...
Cached Medicine News:Health News:White Paper Details How to Choose the Right EMS Provider for Medical Products Outsourcing 2Health News:PET imaging significantly enhances standard imaging in lung cancer staging 2Health News:US Preventive Medicine(R) Says Study on Heart Disease-related Deaths Demonstrates Need for Preventive Medical Care 2Health News:US Preventive Medicine(R) Says Study on Heart Disease-related Deaths Demonstrates Need for Preventive Medical Care 3Health News:Criteria Predict Women's 5-Year Risk for Fracture 2Health News:Other Highlights in the Nov. 27 JNCI 2Health News:Other Highlights in the Nov. 27 JNCI 3Health News:Other Highlights in the Nov. 27 JNCI 4Health News:Drinking and smoking don't boost HPV-related cancer risk 2
... an all-in-one drape made of 3M Steri-Drape ... pouch with filter and exit port. It ... inches (164cm) TUR Drape, Absorbent Prevention Fabric, ... cot, Fluid collection pouch with filter and ...
... Both the Penilab IV and the Penilab V have ... Model 1060 is similar to the Model 1061 ... can one be added later. The Penilab V ... all of the accessories you'll need to get started. ...
The Model 240 is a single-channel instrument designed for penile tumescence monitoring. It features exceptional stability. It's ready for use with most multi-channel recorders having a DC input....
... Integra II SP MRI-Compatible Anesthesia System is perfect ... more than one type of anesthetic agent. ... and due to its wider stance, has a ... ventilator bellows assembly is utilized in both the ...
Medicine Products: