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Study Shows That Roche's Investigational Drug for Alzheimer's Disease Removes Amyloid Plaques From the Brain
Date:10/10/2011

s in patients' brains about 15 years prior to the onset of dementia, ongoing and future clinical studies with gantenerumab will focus on Alzheimer's disease in the early or prodromal phase. It is hoped that early diagnosis and intervention, before significant damage to nerve cells has occurred, will offer optimal benefit to patients.

About the study

The effect of up to six months of treatment with gantenerumab at two different doses or placebo on brain amyloid was measured in 16 patients with mild to moderate Alzheimer's disease using positron emission tomography (PET) and the radiotracer 11C-Pittsburgh Compound B. In addition, Alzheimer's disease brain slices from an independent patient sample were incubated with gantenerumab at increasing concentrations and with human microglia in an ex vivo phagocytosis assay.

The next step will be to investigate whether removal of brain amyloid translates into clinical benefit for patients at doses of gantenerumab that reduce brain amyloid and are well tolerated, with a favorable safety profile.

This is the objective of the SCarlet RoAD trial, which is set to investigate the efficacy and safety of gantenerumab in patients in the early or prodromal stage of Alzheimer's disease. Early or prodromal Alzheimer's disease is a condition in which a person's memory loss is worse than can be expected by the normal ageing process alone, even though their ability to get on with daily activities is not affected to such an extent that they would be diagnosed with dementia.

The SCarlet RoAD study is currently recruiting 360 patients in 15 countries and will look at the effects that gantenerumab has on participants' ability to remember information, to solve problems and to go about day-to-day activities. For more information: http://www.scarletroadstudy.com/  

About gantenerumab (RG1450)

Gantenerumab is an investigational
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SOURCE Roche
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