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Study Shows Progesterone Shots Do Not Reduce Preterm Delivery in Twin Pregnancies
Date:2/13/2013

SAN FRANCISCO, Feb. 14, 2013 /PRNewswire-USNewswire/ -- In a study to be presented today at the Society for Maternal-Fetal Medicine's 33rd annual meeting, The Pregnancy Meeting™, researchers will report findings that suggest that 17P, a form of progesterone, is not effective in preventing preterm birth among women with twin pregnancies — and may possibly be harmful.

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While 17P (17 alpha-hydroxyprogesterone caproate) has been shown to prevent premature delivery among about one-third of women with a singleton pregnancy who have experienced a prior preterm delivery, this latest research shows that 17P prescriptions can't do the same for moms having twins, the authors say.

"We found that 17P was not effective in women with twin pregnancies and a short cervix (defined as less than 25 mm between 24 and 32 weeks)," says Philippe Deruelle , MD, with the Department of Obstetrics and Gynecology at Hopital Jeanne de Flandre,  Universite Lille 2, France, and one of the study's authors.  "We actually seemed to have found an increase in the rate of preterm delivery before 32 weeks in the treatment group when compared to the non-treatment group."

For the study reported in the abstract, entitled: Prevention of preterm delivery by 17 alpha-hydroxyprogesterone caproate in asymptomatic twin pregnancies with a short cervix: a randomized controlled trial, Dr. Deruelle and his colleagues conducted their trial on 165 women over the age of 18 at 10 university hospitals between June 2006 and January 2010. Outcome data was available for 161 of the 165 (97.6%) women.

"Twins are very high risk for preterm delivery, in fact, 60 percent of twins are born too soon. We can't assume that what works for singleton
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SOURCE March of Dimes
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