Navigation Links
Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients
Date:12/9/2010

EAST HANOVER, N.J., Dec. 9, 2010 /PRNewswire/ -- A new study shows that the addition of everolimus (Afinitor® tablets) to the hormonal therapy tamoxifen in patients with hormone-receptor positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer who have been previously treated with an aromatase inhibitor (AI) delays disease progression compared to tamoxifen alone. These results were presented today at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium in San Antonio, Texas(1).  

Findings from a randomized, Phase II study of 111 patients showed the proportion of metastatic breast cancer patients without tumor progression at six months was 61.1% for those taking everolimus plus tamoxifen (95% confidence interval [CI], 46.9 to 74.1) versus 42.1% for patients treated with tamoxifen alone (95% CI, 29.1 to 55.9); p=0.045(1).  

Disease progression was delayed by a median of 8.6 months in patients treated with the combination versus 4.5 months in patients treated with tamoxifen alone, with everolimus in combination with tamoxifen providing a statistically significant reduction in the risk of disease progression by 47% (hazard ratio=0.53 [95% CI, 0.35 to 0.81]; log-rank test: p=0.0026, exploratory analysis). Side effects were generally manageable in both study arms. As of October 2010, there were 25 patient deaths in the tamoxifen arm versus nine in the everolimus plus tamoxifen arm (hazard ratio=0.32 [95% CI, 0.15 to 0.68]; log-rank test: p=0.0019)(1).

This Phase II trial is conducted by the Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens et du sein (the French GINECO Group).

Everolimus is an investigational agent for the treatment of patients with breast cancer. Everolimus targets mTOR in cancer cells, a protein that acts as an important regulator of tumor cell division, blood vessel growth and cell metabolism(7,8).

"The almost doubling of time to di
'/>"/>

SOURCE Novartis
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
6. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
7. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
8. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
11. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Colo. , Jan. 22, 2015  BiOptix is pleased ... as Vice President of Chemistry and Biochemistry. Scott joins ... Pharmaceuticals, AstraZeneca Pharmaceuticals, and Amgen throughout the course of ... development. "Scott is a nationally recognized thought ...
(Date:1/22/2015)... /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), ... for cardiovascular disease and overall health is pleased to provide ... and its outlook for 2015 from the CEO, Mr. ... We would like to take this opportunity to share with ...
(Date:1/22/2015)... Jan. 22, 2015  Profil Institute for Clinical Research, Inc., ... obesity, announced today a new textbook,  Translational Research Methods ... Springer, a leading global scientific publisher. The ... techniques for use in early phase clinical studies of ...
Breaking Medicine Technology:BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3
... , NEW YORK, Nov. 17 Reportlinker.com ... available in its catalogue. , Audiological ... http://www.reportlinker.com/p0164304/Audiological-Devices---Global-Market-Trends.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire , The market ... superior hearing instruments that are less visible and ...
... , NEW YORK, ... market research report is available in its catalogue. ... & Joint Orthopedic Devices 2009 , ... the combined market for small joint, small bone ...
Cached Medicine Technology:Reportlinker Adds Audiological Devices - Global Market Trends 2Reportlinker Adds Audiological Devices - Global Market Trends 3Reportlinker Adds Audiological Devices - Global Market Trends 4Reportlinker Adds Audiological Devices - Global Market Trends 5Reportlinker Adds Audiological Devices - Global Market Trends 6Reportlinker Adds Audiological Devices - Global Market Trends 7Reportlinker Adds Audiological Devices - Global Market Trends 8Reportlinker Adds Audiological Devices - Global Market Trends 9Reportlinker Adds Audiological Devices - Global Market Trends 10Reportlinker Adds Audiological Devices - Global Market Trends 11Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 2Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 3Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 4Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 5Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 6Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 7Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 8Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 9Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 10Reportlinker Adds U.S. Market for Small Bone & Joint Orthopedic Devices 2009 11
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ has ... (PPHA). The PPHA's passion for others' well-being and shared ... treated for obstructive sleep apnea (OSA) has propelled them into ... the valley. The most recent plans for an event will ...
(Date:1/22/2015)... 22, 2015 Blue Cross and Blue Shield ... exemplify what it means to “Live Fearless.” , ... to share their stories about how they or someone they ... others by living in the moment. By telling these types ...
(Date:1/22/2015)... A new white paper by The ... in the long-term care environment as well as provides ... The paper, “The Power of Person-Centeredness in Long-Term Care: ... of the patient, resident and family experience in long-term ...
(Date:1/22/2015)... Carinsurancesavings.biz has released a new blog post presenting the basic ... , Purchasing an accidental death and dismemberment rider for a ... rider provides benefits if the insured dies in an accident. ... of life insurance. , AD&D is not expensive and ...
(Date:1/22/2015)... January 23, 2015 Recently, Weddingshe.com has added ... and has announced its highest annual revenues in the past ... its popular glamorous wedding dresses. , According to the sales ... wedding dress promotions for them in 2015. This point can ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... levels of exhaled nitric oxide in adolescents with asthma and ... disease. , The study was conducted by the Inner ... Institute of Allergy and Infectious Diseases (NIAID), part of the ... The Lancet reports the ICAC findings. , Approximately ...
... 19 Western Australians will be,the first in the ... that,has been shown to improve a person,s ability to ... health initiative will be launched by Australia,s Aged Care,Commissioner ... the,Duxton Hotel on September 19th as part of Dementia ...
... in Non-Invasive Aesthetic Treatments , ... ... http://www.americanlaser.com [American Laser Centers __title__ American Laser], the ... services in the U.S., has announced Kymberly Botelho, the host ...
... a top concern for businesses of all sizes. Just when,employers ... these that complicate the enrollment:, -- Employees don,t ... of what their employer provides. -- Health ... -- A handful of employees who are located in remote ...
... NEW BRUNSWICK, N.J., Sept. 18 Fans ... game this Sunday, September 21, will be,encouraged ... fight: supporting PSE&G Children,s,Specialized Hospital, an inpatient ... premature birth, and life-changing,conditions., (Photo: ...
... Tenn., Sept. 18 Radiation Oncology Services,of America, ... America,Inc., announced today the inaugural meeting of its ... 2008. The Scientific Advisory Board,is comprised of a ... field.,It will advise ROSA on numerous scientific and ...
Cached Medicine News:Health News:Monitoring exhaled nitric oxide does not help manage asthma 2Health News:Monitoring exhaled nitric oxide does not help manage asthma 3Health News:New Brain Fitness Program to Fight Memory Loss 2Health News:New Brain Fitness Program to Fight Memory Loss 3Health News:Popular Denver Divas Host to Manage the New American Laser Centers Clinic in Arvada 2Health News:New Web-Based Enrollment System Gives Employers Flexibility and Control in Managing Benefits Enrollments 2Health News:New Web-Based Enrollment System Gives Employers Flexibility and Control in Managing Benefits Enrollments 3Health News:PSE&G Children's Specialized Hospital and New York Giants Team Up to Enable Donations to Hospital Through Texting 2Health News:Radiation Oncology Services of America, Inc. Announces Formation of Scientific Advisory Board 2
GE's Signa Contour/i system uses the latest innovations from around the world to bring new standards in quality and value to MRI....
... The Intradiscal Instruments are designed ... bodies to aid in disc removal, ... grafts. The set consists of several ... Root Retractors, and a Vertebral Body ...
... Autologous growth factors (AGF) ... blood, the AGF gel delivers ... growth factors and proteins in ... the information of new bone ...
Sony DVD Recorder for recording and playback of DVD video discs to complement DP micro video cameras....
Medicine Products: