Navigation Links
Study Shows Leconotide, an Investigative Calcium Channel Blocker, Has Potential as a Selective, Efficacious, Non-Opioid Pain Treatment
Date:1/28/2009

ute of Medical Research studied 322 rodents in a model of induced diabetic neuropathy and hyperalgesia, or extreme sensitivity to pain. Roughly one-third of the rodents were given injections of two calcium channel blockers (leconotide or ziconotide) alone and in combination with flupirtine (a potassium channel opener). Roughly another third were given a range of doses up to the maximum that would not induce sedation. About half of the rodent's pain was reduced in the group with leconotide compared to less than 1 percent when ziconotide was given alone.

Leconotide in combination with flupirtine increased the reduction of pain, demonstrating selectivity -- it did not act on the channels that cause the side effects seen with ziconotide treatment.

Leconotide is derived from marine hunting cone snail Conus Catus.

About Calcium Channel Blockers

Every cell in the body is enclosed by a membrane which acts as a barrier controlling the flow of chemicals into and out of the cell. Channels through the membrane control the passage of substances into and out of the cell. Some are specialized for the flow of chemical ions such as sodium, potassium and calcium. The amount of ions of each species passing through those channels controls many functions of the cell such as force of contraction of a muscle cell in the heart or blood vessels or rate of electrical firing or production of chemical messengers in nerve cells. Calcium antagonists block calcium channels. There are many types of calcium channels. Medicines can be selective to bind just with one type (e.g. heart and blood vessels to lower blood pressure). Calcium channels in nerve cells are involved with many functions (e.g., pain, memory and control of consciousness). The goal is to find a calcium antagonist that only affects the channels involved with pain to cause pain relief without side effects like feeling sleepy.

    Po
'/>"/>
SOURCE American Academy of Pain Medicine
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Study of Cannabinoid Medicine for Pain Found Patients Got High, but Effects Not Related to Pain Relief
2. Study Shows No Standardized Approach to Epidural Steroid Injections for Back Pain
3. ISTA Pharmaceuticals Announces Positive Results for Phase IIb Study of Ecabet Sodium
4. Intercell AG Partners with Inclinix to Enroll 1800 Volunteers for Phase III Travelers Diarrhea Vaccine Study
5. Thomson Reuters Study Finds Sharp Increase in Use of Sleep Medications by Young Adults
6. Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP
7. Study Shows How Defective DNA Repair Triggers Two Neurological Diseases
8. New Overall Survival Study Results Confirm Oral Xeloda(R) plus Oxaliplatin (XELOX) is Comparable to FOLFOX-4 for the First-Line Treatment of Advanced Colorectal Cancer
9. New Study First to Confirm Sandostatin LAR(R) Depot Controls Tumor Growth in Patients With Rare Gastrointestinal Tumors
10. VA-NIH Study Offers Hope for Parkinsons Patients
11. Uroplasty Highlights Results From Clinical Study on Macroplastique(R) for the Treatment of Stress Urinary Incontinence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... , Nov. 21, 2014  CytoSorbents Corporation ... its European Union approved CytoSorb® cytokine adsorber to ... awarded the Beacon of Light Award at last ... Dr. Phillip Chan , ... an honor to be recognized by the New ...
(Date:11/22/2014)... , Nov. 21, 2014   Long Beach dentist ... are often called the gold standard in tooth replacement because ... a stable, long-lasting way to restore and preserve smiles and ... to replace a missing tooth or as a part of ... the look and feel of a smile. The ...
(Date:11/22/2014)... Fla. , Nov. 21, 2014 MEDITE Group ... reported nine months and the 3 rd quarter sales ... Operating income was $448,000 for the nine months ended September ... 2014. "Even though our 3 rd quarter is usually ... which extends from July into September for many countries worldwide, ...
Breaking Medicine Technology:CytoSorbents Wins Beacon of Light Award 2CytoSorbents Wins Beacon of Light Award 3CytoSorbents Wins Beacon of Light Award 4Long Beach Dentist, Dr. Rassouli, is Now Offering Dental Implants 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 3
... , , , , IRVINE, Calif., Dec. ... Pulse CO-Oximetry(TM) and Measure-Through Motion and Low Perfusion pulse oximetry, today ... Annual J.P. Morgan Healthcare Conference at the Westin St. Francis Hotel ... Pacific Time. A live audiocast of the presentation will be ...
... , , , , , ... speciality pharmaceutical,company focused on the discovery and development of ... microbial drug,resistance, announces today that its shareholders have signed ... for a total cash,consideration of up to $505 million, ...
Cached Medicine Technology:Masimo to Present at the 28th Annual J.P. Morgan Healthcare Conference 2Masimo to Present at the 28th Annual J.P. Morgan Healthcare Conference 3Novexel to be Acquired by AstraZeneca 2Novexel to be Acquired by AstraZeneca 3Novexel to be Acquired by AstraZeneca 4
(Date:11/23/2014)... For the coming special Friday, Tidebuy, ... a great promotion for many products, especially the beautiful ... the best choice with amazing discounts, up to 90% ... , It is easy to buy colored wedding dresses ... selection is also famous for delicate craftsmanship, elegant style ...
(Date:11/23/2014)... Tbdress.com has recently announced that its Special Friday Shoes ... special offer will provide ladies many gorgeous shoes at greatly ... largest women’s dresses retailers, and its shoes include many models ... on that day: Everything at Tbdress.com is up to 90% ... , People can use the following coupon codes as well: ...
(Date:11/23/2014)... November 23, 2014 Nearly 260 ... attacks, strokes, deep vein thrombosis and other serious ... federal multidistrict litigation (MDL) underway in the Northern ... , Court documents updated on November 17th by ... show the filing of 259 lawsuits against the ...
(Date:11/23/2014)... The holidays can be a challenge for families of ... meltdowns, an expert says. "Holidays with family can ... you have children with special needs, some care must ... University of the Sciences in Philadelphia, said in a ... hosts or visitors know what special requirements are needed ...
(Date:11/23/2014)... 23, 2014 This evaluation provides ... its significance, programs and manufacturing technological innovation. Then, ... major market gamers in information. In this part, ... prospective, manufacturing value, and 2009-2014 market shares for ... symbolizes the globally and Chinese suppliers finish market ...
Breaking Medicine News(10 mins):Health News:Beautiful Wedding Dresses Available at Popular B2C Company Tidebuy 2Health News:Tbdress.com Special Friday Shoes Sales Online Now 2Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 2Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 3Health News:Holidays Can Be Sensory Overload for Kids With Autism 2Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 2Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 3Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 4
... ... Officers in MedeFile System During National ... Police Week, CEDAR ... specializing in,portable electronic medical records management solutions, today announced,that in collaboration with the ...
... -- Research findings and innovative approaches offer the promise ... adults living with type 1 diabetes, according to researchers ... Forum in Washington D.C. , Type 1 diabetes is ... insulin-producing beta cells in the pancreas. It renders ...
... A CI head once noted that,"Competitive Intelligence is like ... you realize you need it is when it is ... companies need competitive,intelligence to effectively deal with a turbulent ... that people begin to realize how,critical competitive intelligence is ...
... 18 Sunrise Senior Living,Inc. (NYSE: SRZ ), ... will present at the 2008 Jefferies 2nd Annual,Healthcare Conference ... 1:30 p.m.,Eastern Time. Sunrise will Web cast the presentation ... http://www.sunriseseniorliving.com ). A replay of the Web cast will ...
... Nursing Facility,Funding Cut, COLUMBUS, Ohio, June 18 ... American Health Care Association (AHCA) today,praised Ohio Congressman ... the growing bipartisan effort in Congress to prevent,the ... to,seniors, Medicare Part A nursing home funding - ...
... Inc.,(Nasdaq: HOLX ) today announced that Glenn Muir, ... Annual Healthcare Conference being,held June 24 - 26, 2008, ... Interested parties are invited to listen to a ... 25, 2008, at 12:30 PM.,Eastern Time on the investor ...
Cached Medicine News:Health News:MedeFile International Teams with Newark Fraternal Order of Police 2Health News:MedeFile International Teams with Newark Fraternal Order of Police 3Health News:MedeFile International Teams with Newark Fraternal Order of Police 4Health News:Science, hope for adults with type 1 diabetes focus of JDRF's Annual Global Diabetes Research Forum 2Health News:Science, hope for adults with type 1 diabetes focus of JDRF's Annual Global Diabetes Research Forum 3Health News:Build and Maintain an Effective Competitive Intelligence Group 2Health News:Boehner Thanked for Opposing Funding Cut to Medicare Beneficiaries 2Health News:Hologic to Present at the Jefferies 2nd Annual Healthcare Conference 2
... Clinical Xpert™ for PDAs is a new ... Clinical Xpert puts authoritative drug, disease and ... physicians and other prescribers, nurses, pharmacists, and ... decisions at the point of care, and ...
The 3-chip MediLive Trio Eye video camera is built to adapt to changing conditions during ophthalmic surgery with features designed for workflow optimization and maximum image quality....
... A valuable new tool for ... exhibits greater dynamic range and shows ... SWAP, at the same degree of ... has been shown to correlate with ...
... The VISUCAM non-mydriatic ... quality and simplicity of ... big enough to set ... photography, it features a ...
Medicine Products: