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Study Shows How Defective DNA Repair Triggers Two Neurological Diseases
Date:1/14/2009

nt changes to DNA that lead to cancer.

"Understanding more about how these proteins signal and interact, and how different cells in the body transduce the DNA damage signal, is of fundamental biological importance," McKinnon said. "This knowledge is necessary not only for understanding DNA repair diseases but for understanding the broader implications of maintaining of the stability of DNA."

Other authors of this paper include Erin Shull, Youngsoo Lee, Jingfeng Zhao and Helen Russell (St. Jude); John Petrini and Travis Stracker (Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences); and Hironobu Nakane (formerly of St. Jude).

This research was supported in part by the National Institutes of Health, the National Cancer Institute and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit www.stjude.org.


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SOURCE St. Jude Children's Research Hospital
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