Navigation Links
Study Shows How Defective DNA Repair Triggers Two Neurological Diseases
Date:1/14/2009

cess. However, if the damage is too severe, ATM may also trigger programmed cell death called apoptosis. "It happens that defects in ATM also lead to a disease similar to ATLD, highlighting the connections between diseases resulting from defects in this DNA repair pathway," McKinnon said.

The mice engineered to mimic ATLD, like their human counterparts, had defective genes that produce a protein called Mre11; while NBS mice were engineered to have defects in the gene for the protein called Nbs1.

In their experiments, the researchers produced increased DNA-damage stress in the two types of engineered mice, either by using radiation or knocking out a key enzyme that stitches together broken DNA ends.

The researchers then compared the resulting pathologies in the two types of mice. The scientists found that the brain cells of the ATLD mice but not the NBS mice showed a resistance to apoptosis, meaning that the DNA-damaged cells were more likely to survive, even when crippled. Such cells would ultimately die, however, producing the neurodegeneration characteristic of ATLD in humans. In contrast, the NBS mice showed normal apoptosis, but because fewer brain cells survived, developed significantly smaller brains, like their human counterparts.

"Thus, these findings have allowed us to understand how these different mutations in this one DNA repair complex can lead to different neuropathological outcomes," McKinnon said. The findings could also lead to understanding how carriers of the disease genes are more prone to cancer.

"There is a suspicion that people who carry these mutations may be predisposed to cancer and also more susceptible to chemotherapy agents or even to standard X-rays," McKinnon said. "Those agents induce the type of DNA damage that requires the MRN complex and ATM for repair. More generally, studies of the MRN complex and ATM are fundamental to understanding how to preve
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. New Overall Survival Study Results Confirm Oral Xeloda(R) plus Oxaliplatin (XELOX) is Comparable to FOLFOX-4 for the First-Line Treatment of Advanced Colorectal Cancer
2. New Study First to Confirm Sandostatin LAR(R) Depot Controls Tumor Growth in Patients With Rare Gastrointestinal Tumors
3. VA-NIH Study Offers Hope for Parkinsons Patients
4. Uroplasty Highlights Results From Clinical Study on Macroplastique(R) for the Treatment of Stress Urinary Incontinence
5. Reproductive Partners Participates in New IVF Progesterone Delivery System Study
6. Idenix Pharmaceuticals Initiates Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)
7. InterMune to Conduct Conference Call and Webcast to Discuss Results of Triple Combination Study of ITMN-191
8. ANA598 Demonstrates Potent Antiviral Activity in an Early Clinical Study in HCV-Infected Patients
9. ELAD(R) Liver Support System Study Initiated at Multiple U.S. Centers
10. Study Demonstrates that AHCC(R) Enhances Immune System by Increasing the Production of Key Dendritic Cells
11. Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Jan. 23, 2015  Now available for sale, The Armor1 ... that prevents ankle sprains by cushioning the ankle from ... securely around the outside of any shoe type and ... while still offering protection against sprains. With customers in ...
(Date:1/23/2015)... , Jan. 23, 2015   Leatt Corporation  (OTCQB: ... protective equipment for all forms of sports, including extreme ... neck brace, announced today that the UISP Lega Motociclismo ... requires all riders to wear a neck brace during ...
(Date:1/23/2015)... and BOSTON , January 23, ... drug discovery and development company, is delighted to announce that ... been awarded to Miles Congreve (Vice President of ... and Malcolm Weir (Chief Executive Officer and co-founder) ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4
... The new online pharmacy was launched after the company ... there are not enough reliable and trustworthy places to shop ... experience the company has, launching a website that would offer ... matter of time and patience. The new drugstore is bound ...
... AdvaMed 2010 : The MedTech ... of free educational Executive Workshops focused on bringing products to ... risk and global harmonization. The workshops take place at the ... and include speakers from the U.S. Food and Drug Administration, ...
Cached Medicine Technology:New Online Pharmacy RxBuys.com is Launched by One of the Leading Pharmaceutical Companies, Rx Corp 2Medical Device Conference Opens October 18, 2010 With Free Executive Workshops; Full Conference Highlights Latest Industry Trends, Technology Innovations and Keynote Speeches by the U.S. FDA Commissioner, U.S. CMS Administrator, CBS Evening News Anc 2
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, ... Health Alliance (PPHA). The PPHA's passion for others' well-being ... NFL greats, treated for obstructive sleep apnea (OSA) has propelled ... cause in the valley. The most recent plans for an ...
(Date:1/22/2015)... 22, 2015 Blue Cross and Blue Shield ... exemplify what it means to “Live Fearless.” , ... to share their stories about how they or someone they ... others by living in the moment. By telling these types ...
(Date:1/22/2015)... Dallas, TX (PRWEB) January 22, 2015 ... the issue of experience and person-centeredness in the long-term ... moving towards action across the continuum. The paper, “The ... the Continuum,” engages perspectives and practices of the patient, ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 Recently, Weddingshe.com has ... catalog, and has announced its highest annual revenues in the ... on its popular glamorous wedding dresses. , According to the ... important wedding dress promotions for them in 2015. This point ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... University of Rochester, there are several risk factors for development ... young age, massive surgery, and severe post-operative pain. ... by nearly 50% of all women undergoing a lumpectomy or ... armpit and in the upper arm on the same side. ...
... line from a lifeless human embryo. Ethical issues may ... naturally//. ,The study and treatment ... stem cells has raised ethical concerns due to the ... ,Researcher Miodrag Stojkovic said, "The study shows that ...
... a drastic fall in the capabilities of the brain, ... strategies // have focused on tackling such issues; it ... not suffer pain. ,A pioneering effort by ... fallacy about Alzheimer’s and the sensation of pain. The ...
... to enable manifold benefits for patients, but health ... before such drugs are recommended for their patients, ... (GI) morbidities are becoming common fallouts of NSAID ... upper- and lower-GI tracts; this may include even ...
... genetically engineered mice has revealed that the dreaded white ... transplants may also help prevent such damage//, according to ... that when blood flow is cut off and then ... cells called T lymphocytes produce toxic natural chemicals that ...
... and mammals in the form of a primitive version of ... been discovered by researchers from the University of Pennsylvania School ... of the adaptive immune system in mammals, where B cells ... immunity in fish, where they found that B cells take ...
Cached Medicine News:Health News:Post-Operative Pain in Breast Cancer Surgery 2Health News:Nonsteroidal anti-inflammatory drugs could cause gastrointestinal complications. 2Health News:Nonsteroidal anti-inflammatory drugs could cause gastrointestinal complications. 3Health News:Study Reveals Effects of WBCs on Transplanted Kidney 2Health News:Study Reveals Effects of WBCs on Transplanted Kidney 3Health News:Link between Fish and Mammal Immune Systems Revealed by Killer B cells 2Health News:Link between Fish and Mammal Immune Systems Revealed by Killer B cells 3
Midstream Catch Kits...
... is a portable, noninvasive ultrasound instrument that ... to use, and quickly provides accurate results. ... use the BladderScan® to obtain a precise ... BladderScan® supplies the information that caregivers need ...
... Mobile BladderScan® BVI 6400 calculates bladder ... technology. V-MODE® ultrasound is accurate, fast, ... the BladderScan® measures ultrasonic reflections within ... creates a 3-dimensional image of the ...
... The Titan™ Inflatable Penile Prosthesis ... designed to be surgically implanted ... management of erectile dysfunction (also ... provides the patient with voluntary ...
Medicine Products: