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Study Shows Gradual Addition of NovoLog® at Mealtime Can Reduce A1c in Type 2 Diabetes Patients
Date:6/28/2010

outlined in the study, can be equally effective, whether using a more intuitive approach (like SimpleSTEP) or one with more frequent, precise measurements of blood sugar levels (like ExtraSTEP), for intensifying therapy in patients with type 2 diabetes to lower A1c levels.  

"A significant challenge for physicians treating patients with type 2 diabetes is figuring out how to introduce a meal-time insulin when basal insulin with or without oral medications is no longer enough to keep blood sugar levels stable," said Luigi Meneghini, M.D., M.B.A., lead investigator in the STEPwise™ trial, Professor of Clinical Medicine at the University of Miami Miller School of Medicine. "With the SimpleSTEP and ExtraSTEP algorithms, we have identified an approach for how to gradually introduce and intensify doses of NovoLog® at mealtimes in patients who increasingly need glucose control as their diabetes progresses."

More details of the study will be presented at the American Diabetes Association's Scientific Sessions in Orlando, FL on Monday, June 28 during Poster Session III, 12:00-2:00  p.m. in the Orange County Convention Center, Hall C.

About the STEPwise Trial(1)

The trial involved 296 patients, at an average age of 58 and mean A1c of 8.8% on basal insulin and oral medications. The primary efficacy endpoint was HbA1c after 36 weeks of treatment. Treatment was given with Levemir® FlexPen® once daily in combination with NovoLog® FlexPen® one to three times daily, before meals, with the dose adjusted individually based on defined titration guidelines developed for the study.

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SOURCE Novo Nordisk
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