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Study Reveals Potential for NT-proBNP as a Marker to Predict Cardiovascular Risks From Anti-Inflammatory Drugs
Date:7/23/2008

Study results pending publication in July print edition of Clinical

Chemistry, available on Web

INDIANAPOLIS, July 23 /PRNewswire/ -- A Roche Diagnostics-sponsored pilot study evaluating the use of N-terminal pro-B-type natriuretic peptide (NT-proBNP) confirms the potential value of NT-proBNP for risk stratification in predicting the risk of cardiovascular adverse events (CV-AE) in patients treated with non-steroidal anti-inflammatory drugs of the COX inhibitor class.

The complete results of the study, currently available at http://www.clinchem.org , are scheduled for publication in the July print edition of Clinical Chemistry.

Non-steroidal anti-inflammatory drugs (NSAIDs) -- for example, acetylsalicylic acid and ibuprofen -- are the best known inhibitors of COX (cyclo-oxygenase), an enzyme involved in the inflammation pathway. This inhibition provides relief from the symptoms of the inflammation process; for example, fever and pain.

These drugs are routinely used to treat patients with osteoarthritis, rheumatoid arthritis and other pathologies associated with inflammation. However, studies with newer NSAIDs such as the selective COX-2 inhibitors (also called coxibs) have resulted in concern that there might be an increase in the risk of heart attack, thrombosis or stroke associated with long-term, high-dosage use of coxibs. Traditional NSAIDs (tNSAIDs) demonstrate comparable risks in observational studies.

Cardiovascular risk could be predicted

A pilot study(1) examined whether the risk of CV-AE could be predicted by measuring the NT-proBNP concentration in patients taking anti-inflammatory drugs. Baseline samples were measured by Elecsys proBNP (Roche Diagnostics) in 433 patients with osteoarthritis of the knees, with or without osteoarthritis of the hands, during an observational period of 200 days.

Cardiovascular adverse events -- including myocardial infarction, stroke, new or worsening of pre-existing arterial hypertension, congestive heart failure, and several less severe CV events -- were monitored and retrospectively related to the use of coxibs, tNSAIDs and glucocorticoids.

NT-proBNP value of 100 ng/L as cut-off

The results of the pilot study showed that NT-proBNP values greater than 100 ng/L could be linked to an increase in the cardiovascular risk. Of the 433 patients, 82 mild-to-serious CV-AE were observed (18.9%) during the 200 days. Most of these events were observed in patients with NT-proBNP concentrations .100 ng/L. The risk for CV-AE in patients with NT-proBNP values .100 ng/L was 1.95-fold higher (p<0.05) for patients treated with any of the inhibitors (tNSAIDs, glucocorticoids or coxibs), 7.41-fold higher (p<0.01) for patients treated with coxibs (alone or in addition to tNSAIDs or glucocorticoids), and 3.74-fold higher (p<0.05) for patients treated with two or more anti-inflammatory drugs.

These patients were compared to those in the corresponding group with NT-proBNP values <100 ng/L.1 For instance, in the coxib group only 9% of patients with NT-proBNP values <100 ng/L showed CV-AEs compared to 41% of patients with NT-proBNP values .100 ng/L. NT-proBNP concentrations <100 ng/L were associated with a negative predictive value (NPV) of 85.5% across all treatment groups. With the highest NPV of 90.9% the potential of NT-proBNP to predict CV-AE was strongest for the coxibs group.

"Based on the result of this study, it appears that patients with values below 100 ng/L of NT-proBNP have a low risk of CV-AE from treatment with anti-inflammatory drugs," said Evangelos Giannitsis, Department of Internal Medicine, University Hospital of Heidelberg, Germany -- a key pilot study investigator.(1)

When confirmed with additional, larger data sets with more reliable endpoints, monitoring NT-proBNP could provide a promising strategy for predicting cardiovascular risk in patients with osteoarthritis, and possibly other pathologies associated with the use of anti-inflammatory drugs. Further studies, however, are necessary.

"This study suggests a new, important application that could offer routine screening and monitoring for the risk of cardiovascular adverse events to physicians and patients," Dr. Giannitsis said.

About Roche

Headquartered in Basel, Switzerland, Roche is one of the world's leading research-focused healthcare groups in the fields of pharmaceuticals and diagnostics. As the world's biggest biotech company and an innovator of products and services for the early detection, prevention, diagnosis and treatment of diseases, the Group contributes on a broad range of fronts to improving people's health and quality of life. Roche is the world leader in in-vitro diagnostics and drugs for cancer and transplantation, and is a market leader in virology. It is also active in other major therapeutic areas such as autoimmune diseases, inflammatory and metabolic disorders and diseases of the central nervous system. In 2007, sales by the Pharmaceuticals Division totalled 36.8 billion Swiss francs, and the Diagnostics Division posted sales of 9.3 billion francs. Roche has R&D agreements and strategic alliances with numerous partners, including majority ownership interests in Genentech and Chugai, and invested over 8 billion Swiss francs in R&D in 2007. Worldwide, the Group employs about 79,000 people. Additional information is available on the Internet at http://www.roche.com .

References

(1) Brune K, Katus HA, Moecks J, Spanuth E, Jaffe AS, Giannitsis E. The Concentration of N-Terminal Pro-B-type Natriuretic Peptide Predicts the Risk of Cardiovascular Adverse Events from Antiinflammatory Drugs: A Pilot Trial. Clin Chem. May 1, 2008 (electronic publication ahead of print), to be published in July 2008.

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