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Study Results of Novocure's NovoTTF™ Pivotal Phase 3 Trial Published in European Journal of Cancer
Date:5/21/2012

rogression-free survival rate at six months was 21.4% and 15.1% (p=0.13), in NovoTTF and active control patients, respectively.  Radiological responses were comparable (14% versus 9.6%, p=0.19), with 3% complete responses seen only in the NovoTTF arm.

The most common NovoTTF-related adverse events were principally mild (14%) to moderate (2%) skin rash beneath the device's transducer arrays.  Severe adverse events occurred in 6% of patients treated with NovoTTF vs 16% for those treated with chemotherapy (p=0.02).  Quality of life analyses favored NovoTTF therapy in most domains, including vomiting, nausea, pain, diarrhea, constipation, and cognitive and emotional functioning.

"The patients treated within this trial had very, very advanced disease. Most of our patients rapidly become independent in handling the device and loved having a treatment without the need for chemotherapy," said Dr. Roger Stupp of the University of Lausanne, lead author of the study.  "We are encouraged by our findings and the future groundbreaking potential of NovoTTF therapy in this tough-to-treat disease and other cancer."

The study's co-principal investigator Dr. Philip Gutin, Chair of the Department of Neurosurgery and Co-Executive Director of the Brain Tumor Center at Memorial Sloan Kettering Cancer Center in New York said, "Patients who have GBM face significant challenges, and we as physicians currently have limited treatment options.  This study shows that a new, safe and effective treatment option is now available."

"The results of this important trial clearly show that a fourth treatment modality now exists for patients with recurrent GBM," said Asaf Danziger, Novocure's Chief Executive Officer. "We are working closely with many of the leading cancer centers in the world to make NovoTTF therapy available to their patients, and will continue to develop this new cancer fighting weapon to improve the lives of people suffering f
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SOURCE Novocure
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