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Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel
Date:3/29/2008

Clinical outcomes, including the primary study endpoint, stent thrombosis and net clinical benefit (all- cause death/MI/stroke/TIMI major bleeding) were assessed using survival analytic techniques.

Analyses that consider all 12,844 patients with stents include all three stent groups. Subjects were classified as having received bare metal stents (BMS), drug-eluting stents (DES), or a combination of stent types at the time of the index PCI. Analyses of DES and BMS individually include patients who received DES only or BMS only, respectively, and patients with a mix of stents (<5 percent of the trial population) were excluded from the analysis of BMS or DES only subjects as they did not clearly fit into either group.

About prasugrel

Daiichi Sankyo Company, Limited (TSE: 4568), and Eli Lilly and Company (NYSE: LLY) are co-developing prasugrel, an investigational oral antiplatelet agent discovered by Daiichi Sankyo and its Japanese research partner, Ube Industries, Ltd., as a potential treatment, initially for patients with acute coronary syndrome who are managed with PCI. Prasugrel works by inhibiting platelet activation and subsequent aggregation by blocking the P2Y12 adenosine diphosphate (ADP) receptor on the platelet surface. Antiplatelet agents prevent platelets from clumping or sticking together, which can result in clogged arteries and may lead to heart attack or stroke.

Lilly, on behalf of its alliance partner, Daiichi Sankyo, submitted a New Drug Application to the U.S. Food and Drug Administration for prasugrel in December 2007, and in February was granted priority review designation by the regulatory agency. Lilly, on behalf of the alliance, also submitted a Marketing Authorization Application for prasugrel to
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SOURCE Eli Lilly and Company
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