Navigation Links
Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily
Date:6/9/2009

fil 2.5 mg, 10 mg, 20 mg, 40 mg or placebo, orally once a day as monotherapy or as add-on therapy to bosentan. The primary endpoint was change from baseline to Week 16 in six-minute walk distance (6MWD)(2). Demographics, clinical data and health-related quality of life data were collected at baseline. Clinical and health-related quality of life data were collected again at weeks eight and sixteen(3).

Tadalafil increased 6MWD in a dose-dependent manner, only the 40 mg dose met the pre-specified level of statistical significance of less than 0.01 (p<0.01). Overall, the placebo-corrected treatment effect was 33m (95 percent confidence-interval, 15m to 50m). In the bosentan-naive group, the treatment effect was 44m (95 percent confidence-interval, 20m to 69m), as compared to 23m (95 percent confidence-interval, -2m to 48m) in patients on background bosentan therapy.

Among secondary objectives, patients administered tadalafil 40 mg showed improvement in time to clinical worsening, as compared to placebo (5 percent for tadalafil 40 mg, versus 16 percent with placebo)(4,5). Additionally, the incidence of clinical worsening was reduced in the 40 mg tadalafil group (p=0.038; relative risk reduction 68 percent less than placebo).

Improvements in the tadalafil 40 mg dose group, compared to placebo, from baseline to Week 16 were observed in six of the eight domains of the SF-36 health survey and for all sections of the EQ-5D questionnaire(6).

The most commonly reported adverse events for tadalafil 40 mg were headache (42 percent for tadalafil 40 mg, versus 15 percent with placebo), myalgia (14 percent for tadalafil 40 mg, versus 4 percent with placebo) and flushing (13 percent for tadalafil 40 mg, versus 2 percent with placebo)(7,8,9). Most adverse events were reported as mild or moderate and discontinuation rates were similar across all treatment groups(10).

About ADCIRCA


'/>"/>

SOURCE United Therapeutics Corporation
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
6. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
7. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
8. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
11. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... Cardiologists at Beaumont Hospital, Royal ... implant of a device recently approved by the Food ... The Watchman Left Atrial Appendage Closure implant is an ... reduce the risk of stroke. Atrial fibrillation ... than 5 million Americans. Twenty percent of all strokes ...
(Date:3/26/2015)... 2015 According to a new ... Technology (RF, Microwave, Cryoablation, Others), Department (Interventional Radiology, Surgery, ... Metastasis) - Global Forecasts to 2019", published by MarketsandMarkets, ... $462.0 Million growing at a CAGR of 11.50% by ... 57 figures spread through 195 pages and in-depth TOC ...
(Date:3/26/2015)... NORTH CHARLESTON, S.C. , March 26, 2015 ... issues and were told by their existing PACS vendor ... Memorial Hospital (CMH) determined that they needed a ... Clinch Memorial Hospital selected Avreo interWORKS due to ... that carries modern meaningful use standards through to ...
Breaking Medicine Technology:Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 2Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 3Tumor Ablation Market Worth $462.0 Million by 2019 2Tumor Ablation Market Worth $462.0 Million by 2019 3Tumor Ablation Market Worth $462.0 Million by 2019 4Clinch Memorial Hospital Modernizes Workflow with Avreo interWORKS 2
... October 12, 2011 Aircraft Medical ("Aircraft"), ... has signed an exclusive agreement with Covidien (NYSE: ... products with 2010 revenue of $10.4 billion, and 41,000 ... agreement, Covidien will market and distribute Aircraft,s proprietary McGRATH ...
... October 12, 2011 OctreoPharm Sciences ... today that the European Medicines Agency has granted ... for the diagnosis of gastro-entero-pancreatic neuroendocrine tumours. ... to ten year market exclusivity in Europe following ...
Cached Medicine Technology:Aircraft Medical Signs Multinational Distribution Agreement with Covidien for McGRATH® MAC Video Laryngoscope 2OctreoPharm Sciences Receives Orphan Drug Designation for SOMscan® for the Diagnosis of Neuroendocrine Tumours 2
(Date:3/26/2015)... Visiting Nurse Association of Northern New Jersey (VNA) ... Way, Brightening the Day, on Friday, May 1, 2015 ... NJ. , Guests will enjoy an elegant evening ... cuisine, an extensive silent auction and heart-warming testimony from ... will be presented to this year’s honorees. , ...
(Date:3/26/2015)... Pacific Medical LLC, the leader in ... featured on Innovations with Ed Begley Jr, which aired ... The episode will repeat on local cable channels by ... Medical home page at: http://www.pacificmedicalsupply.com . , ... reassuring to trust the integrity of the medical equipment ...
(Date:3/26/2015)... Spring, Md. (PRWEB) March 26, 2015 ... fully supports the Patients’ Access to Treatments Act ... Representatives this week by Reps. David B. McKinley ... legislation will limit cost-sharing requirements for medications placed ... more accessible by reducing patients’ out-of-pocket expenses. , ...
(Date:3/26/2015)... FL (PRWEB) March 26, 2015 ... its brand-new, state-of-the-art company website: http://www.metabolicnutrition.com . ... the revamped website creates a user-friendly experience for ... company. , The new, enhanced Metabolic Nutrition ... information about the company’s diverse line of products, ...
(Date:3/26/2015)... The beauty industry united on Saturday, March 21, ... the business of beauty education. The Beauty Changes Lives ... Point International, Inc. Passage’s wife Lenie, and son Robert ... the Art Institute of Chicago, the sold-out event was ... leaders and served as the signature gala event for ...
Breaking Medicine News(10 mins):Health News:Morristown VNA Fundraiser to Honor Distinguished Community Members 2Health News:Pacific Medical Featured on the Discovery Channel 2Health News:Pacific Medical Featured on the Discovery Channel 3Health News:Pulmonary Hypertension Association Part of Coalition Supporting the Patients’ Access to Treatments Act 2Health News:Metabolic Nutrition Launches Sleek New Website with New Features and Enhanced Consumer Information 2Health News:#BeautyChangesLives Legacy Award Pays Tribute to Industry Icon Leo Passage 2Health News:#BeautyChangesLives Legacy Award Pays Tribute to Industry Icon Leo Passage 3
... Platform to Help Marshfield Healthcare Professionals Efficiently Deliver ... SAP AG (NYSE: SAP ... Clinic has selected the comprehensive SAP(R) BusinessObjects(TM) ... business intelligence (BI) system. Offering simple, intuitive BI ...
... OMAHA, Neb., Feb. 9 Senior Market Sales, Inc., ... Brown and Brown of California, Inc., dba CalSurance, to ... discounted rates. The initial open enrollment period launched Feb. ... Market Sales can now enroll for an 18-month policy ...
... 9 New research that delivers,timely studies with operational ... commercialization is now available in the Best,Practice Database, an ... Practices, LLC. , To review ... studies, go to a landing page with links to ...
... Office Expands with Appointment of New Strategic Talent -WEST ... strategic interactive marketing agency serving the healthcare industry, today ... the addition of four key new hires. Three of ... Group,s Manhattan offices which were established in 2007."We,re excited ...
... Fla., Feb. 9 MEDai, Inc., a leading provider ... it is offering a free case study on its ... analytic solution Risk Navigator Clinical(R) and its,application to keep ... The case study explores how one of MEDai,s ...
... reveal secrets behind healthy changesSAN DIEGO, Feb. 9 ... cofounder Michael Roizen, MD, will share the secrets to motivating ... annual ePharma Summit in Philadelphia on February 10, 2009. Sharing ... lost 35 pounds, and transformed her life, Dr. Roizen will ...
Cached Medicine News:Health News:Marshfield Clinic Selects SAP(R) BusinessObjects(TM) Solutions to Improve Patient Treatment and Clinic Management 2Health News:Marshfield Clinic Selects SAP(R) BusinessObjects(TM) Solutions to Improve Patient Treatment and Clinic Management 3Health News:Marshfield Clinic Selects SAP(R) BusinessObjects(TM) Solutions to Improve Patient Treatment and Clinic Management 4Health News:Marshfield Clinic Selects SAP(R) BusinessObjects(TM) Solutions to Improve Patient Treatment and Clinic Management 5Health News:Marshfield Clinic Selects SAP(R) BusinessObjects(TM) Solutions to Improve Patient Treatment and Clinic Management 6Health News:Senior Market Sales Offers Discounted E&O Insurance for Agents 2Health News:Senior Market Sales Offers Discounted E&O Insurance for Agents 3Health News:Best Practice Database adds Research Highlighting the Value of Internal Consulting and Early-Stage Commercialization Groups in the Pharmaceutical Industry 2Health News:Cadient Group Continues Growth Trend with Key New Hires 2Health News:Health Plans Use MEDai to Forecast, Rank Risk and Drive Interventions 2Health News:Oprah Show Expert and RealAge Cofounder Headlines ePharma Talk 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: