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Study Published in Molecular Therapy Shows that Immune Response to FANG™ Personalized Cancer Therapeutic Correlates with Prolonged Survival in Patients with Advanced Stage Cancer
Date:3/1/2012

 immune cells and  prevents production of proteins that tumors use to avoid detection by the immune system. I believe that this triad approach may one day make it possible to turn cancer into a manageable chronic disease for many patients."

Eighteen patients who received FANG were evaluated using enzyme-linked immunospot (ELISPOT) assays to determine the extent of their cellular immune response to the FANG vaccine. Positive ELISPOT responses at four months were demonstrated in nine of the 18 patients evaluated, and this response was correlated to survival benefit (p=0.025). Positive immune response to FANG is durable, as seven of the nine ELISPOT responders were still alive when the manuscript was accepted for publication, having survival up to 500 days since start of treatment.  Routine, post-treatment monitoring of this patient group reveals that these seven patients are still alive today with survival ranging from 464 to 940 days. 

"In this study, FANG has prolonged life for a number of patients with advanced stage cancer who otherwise had little or no other treatment options," said David Shanahan, president, CEO and co-founder of Gradalis. "This study suggests that FANG may be applicable to multiple types of advanced cancer and may ultimately provide new treatment options, even for patients who have late stage or aggressive cancer."

FANG is currently being evaluated in several Phase 2 studies in patients with advanced ovarian cancer, advanced melanoma and advanced colorectal cancer with liver metastases.  In addition, Gradalis has initiated a clinical program evaluating FANG in children with Ewing's sarcoma.

About FANG

The FANG vaccine is manufactured from a cell suspension derived from a marble-sized portion of a patient's tumor removed during surgery. A plasmid expressing a well-established immune activator, granulocyte macrophage colony stimulating factor (GMCSF), and Gradalis' proprietary bi
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SOURCE Gradalis, Inc.
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