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Study Published in Endocrinology Reports Potential of Modigene Technology to Extend Duration of Protein Drugs
Date:9/24/2007

ignificantly longer duration of effect and comparative biological efficacy in studies in the most common and relevant animal models. The CTP technology has been validated in human studies by Akzo Nobel's healthcare division, Organon International, which has rights to the technology for four endocrine proteins. Organon recently advanced its CTP follicle-stimulating hormone (FSH) product into Phase III trials after Phase II studies showed that a single injection provided the same clinical effect as seven daily injections of standard FSH.

ABOUT CTP

Modigene's technology was discovered by researchers at Washington University in St. Louis and is based on a short amino acid sequence, the Carboxyl Terminal Peptide (CTP). CTP occurs naturally in humans, and when attached to a therapeutic protein, extends the time that the protein is active in the body. The potential clinical utility of the technology has been demonstrated by Organon International, a unit of Akzo Nobel, which has a license to the CTP technology for certain endocrine proteins. Organon recently initiated Phase III trials of its CTP follicle stimulating hormone product (FSH-CTP), after Phase II results demonstrated that a single injection of FSH-CTP provides the same clinical effect as seven consecutive daily injections of standard FSH. The Phase II trials also demonstrated that attaching the CTP peptide did not affect the therapeutic activity of FSH or cause a negative immune system response.

1. Development of a Long-Acting Erythropoietin by Fusing the Carboxyl-

Terminal Peptide of Human Chorionic Gonadotropin b-Subunit to the

Coding Sequence of Human Erythropoietin," Fuad Fares, Sherif Ganem,

Taleb Hajouj, and Ester Agai, Endocrinology 148(10):5081-5087. The

study is currently available in the on-line edition of the journal.

ABOUT MODIGENE

Modigene Inc. (OTC Bulletin Board: MODG) is a biopharmaceutical company applying its patented CTP technol
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SOURCE Modigene Inc.
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