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Study Finds Treatment with Metreleptin Improved Diabetes and Lipid Control in Patients with Partial Lipodystrophy
Date:6/4/2011

al presentation today at ENDO 2011. Dr. Oral was instrumental in initiating the first studies to investigate the therapeutic utility of leptin replacement in lipodystrophy while she was working at the National Institutes of Health (NIH). She is currently the Medical Director of the University of Michigan Health System (UMHS) Bariatric Surgery Program and Director of the UMHS' Metabolism, Endocrinology and Diabetes (MEND) Obesity and Metabolic Disorder Program.

Dr. Oral's team will also be presenting a poster at ENDO 2011 entitled, "Treatment of Severe Lipodystrophy with Metreleptin in a Patient with Active Juvenile Dermatomyositis" on Sunday, June 5 at 1:30 p.m. ET.

Study Findings from Oral Presentation (OR07-3)

The findings of this study involve an analysis of nine patients with partial lipodystrophy who received metreleptin treatment for more than six months. At baseline, 89 percent were not achieving adequate glycemic control (A1C greater than or equal to 7 percent), and 89 percent had hypertriglyceridemia (triglycerides greater than or equal to 150 mg/dL). Metreleptin treatment resulted in a reduction in mean A1C from 8.1 percent at baseline to 6.8 percent at six months, which was sustained through 15 months. Additionally, at six months, patients who were taking insulin experienced an average reduction of 110 units in their total daily insulin dose. Similarly, mean triglyceride concentrations were reduced from 318 mg/dL at baseline to 169 mg/dL at 15 months.

Safety observations were generally consistent with those observed in other studies, with the most common adverse events being fatigue and nausea.

These results complement findings obtained in other studies which, collectively, provide evidence to help support the potential efficacy and safety of metreleptin across a range of rare, generalized and partial lipodystrophy syndromes.

About Lipodystrophy

Lipodystrophy syndromes are characterized by a
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SOURCE Amylin Pharmaceuticals, Inc.
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