Navigation Links
Study Finds New Blood Thinning Medication, Pradaxa®, Comes at High Cost

ST. PAUL, Minn., Oct. 20, 2011 /PRNewswire/ -- Treating patients with the new blood thinning medication dabigatran (Pradaxa®), instead of warfarin results in significantly higher per patient costs and higher net costs per stroke avoided, according to a new study by pharmacy benefit manager Prime Therapeutics (Prime).The study will be presented today at the Academy of Managed Care Pharmacy's Educational Conference in Atlanta, Ga.

Dabigatran is a type of blood-thinning medication used to reduce the risk of stroke and blood clots in patients with non-valvular atrial fibrillation, a common heart arrhythmia. The pivotal FDA approval study (RE-LY) (1) found dabigatran may be safer than warfarin for some patients and may reduce the risk of stroke more than warfarin. Unlike warfarin, which has been available for more than 50 years, dabigatran does not require monthly blood tests to monitor the drug's effectiveness.

However, according to Prime's analysis, the reduction in regular lab tests doesn't outweigh significantly higher costs of dabigatran. The RE-LY study showed the number needed to treat (NNT) with dabigatran to prevent one stroke compared to warfarin was 137 patients. Based on the per patient per year (PPPY) costs, this means treating 137 patients with dabigatran instead of warfarin would result in additional medical and pharmacy costs of $279,617 to avoid one stroke at a cost of $26,407 (based on Medicare figures). Total net cost to avoid one stroke would be $253,210.

To determine these differences in cost, researchers from Prime, and the Health Care Service Corporation in Chicago, Ill., reviewed pharmacy and medical claims from two million commercial members. They identified 13,337 individuals continuously enrolled in 2009 who had a warfarin claim in January 2009, cumulative warfarin supply of at least 270 days, and at least one medical claim indicating warfarin management/monitoring.

Of the continuously enrolled members, 2,975 patients met warfarin monitoring criteria and the PPPY total warfarin management costs were $544 ($496 medical plus $48 pharmacy) while the total dabigatran PPPY costs were $2,585 ($118 medical for an estimated two office visits and $2,467 pharmacy).

"Dabigatran is attractive to patients because of its convenience and potential clinical benefit, but its convenience comes at a high cost," said Patrick Gleason, PharmD, director of clinical outcomes assessment at Prime. "Even when we consider the savings from fewer blood tests, there is a substantial increase in cost to treat patients with dabigatran compared to warfarin to prevent one stroke. Health plans should weigh the benefits and added costs when making decisions about where dabigatran should be placed on a formulary."

(1) Connolly SJ, Ezekowitz MD, Eikelboom J, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139-51

Prime Therapeutics is a pharmacy benefit management company dedicated to providing innovative, clinically-based, cost-effective pharmacy solutions for clients and members. Providing pharmacy benefit services nationwide to nearly 17 million covered lives, its client base includes Blue Cross and Blue Shield Plans, employer and union groups, and third-party administrators. Headquartered in St. Paul, Minnesota, Prime Therapeutics is collectively owned by 12 Blue Cross and Blue Shield Plans, subsidiaries or affiliates of those Plans. Learn more at

SOURCE Prime Therapeutics
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
6. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
7. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
8. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
11. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
Post Your Comments:
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
Breaking Medicine Technology:
(Date:6/27/2016)... ... 2016 , ... "FCPX editors can now reveal their media with growing colorful ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings the ... can now reveal the media of their split screens with growing colorful panels. , ...
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
Breaking Medicine News(10 mins):