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Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer
Date:12/14/2008

rmal) * Myelosuppression may occur; frequently monitor complete blood count (including platelet count), at least prior to each dose of DOXIL - In patients with recurrent ovarian cancer or AIDS-related Kaposi's sarcoma, hematologic toxicity (based on platelet count or absolute neutrophil count) may require dose reduction or delay in administration of DOXIL - In patients with multiple myeloma, hematologic toxicity (based on platelet count, absolute neutrophil count, hemoglobin level, or neutropenia with fever) may require dose reduction, delay in administration, or suspension of DOXIL and/or VELCADE - Persistent severe myelosuppression may result in superinfection, neutropenic fever, or hemorrhage - Sepsis occurring during neutropenia has resulted in discontinuation of treatment and in rare cases of death * DOXIL may potentiate the toxicity of other anticancer therapies, especially hematologic toxicities, when used in combination with other therapies that suppress bone marrow * Hand-foot syndrome (HFS) may occur during therapy with DOXIL - Based on HFS toxicity grade, dose reduction, or delay in administration, or discontinuation of DOXIL may be required - HFS was generally observed after 2 to 3 cycles of treatment, but may occur earlier - The reaction was mild in most patients, resolving in 1 to 2 weeks - The reaction can be severe and debilitating in some patients, resulting in discontinuation of therapy * DOXIL is an irritant, not a vesicant; use precautions to avoid extravasation * DOXIL can cause fetal harm when used during pregnancy * Recall reaction has occurred with DOXIL administration after radiotherapy * DOXIL may interact with drugs known to interact with the conventi
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SOURCE Ortho Biotech Products, L.P.
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