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Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer
Date:12/14/2008

) versus 1% (Grade 3/4 0%) * Stomatitis: 52% (Grade 3/4 11%) versus 14% (Grade 3/4 1%) * Alopecia: 48% versus 45% * Asthenia: 29% (Grade 3/4 4%) versus 20% (Grade 3/4 3%) * Nausea: 28% (Grade 3/4 1%) versus 22% (Grade 3/4 <1%) * Fatigue: 20% (Grade 3/4 3%) versus 15% (Grade 3/4 2%)

The study was sponsored by Ortho Biotech Oncology Research & Development (ORD), a unit of Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

About DOXIL(R)

DOXIL is indicated for the treatment of patients with ovarian cancer whose disease has progressed or recurred after prior platinum based therapy. DOXIL in combination with VELCADE(R) (bortezomib) is indicated for the treatment of patients with multiple myeloma who have not previously received VELCADE and have received at least one prior therapy. DOXIL is also indicated for the treatment of AIDS-related Kaposi's sarcoma in patients after failure of prior systemic chemotherapy or intolerance to such therapy.

    IMPORTANT SAFETY INFORMATION

BOXED WARNINGS:

Cardiotoxicity, infusion reaction, myelosuppression, liver impairment, substitution

     * The use of DOXIL may lead to cardiac toxicity. Myocardial damage may
       lead to congestive heart failure and may occur as the total cumulative
       dose of doxorubicin HCl approaches 550 mg/m2
         - Prior use of other anthracyclines or anthracenediones should be
           included in calculations of total cumulative dose
         - Cardiac toxicity may also occur at lower cumulative doses (400
           mg/m2) in patients with prior mediastinal irradiation or who are
           receiving concurrent cyclophosphamide therapy
     * Acute infusion-related reactions including, but not limited to,
       flushing, shortness of breath, facial swelling, headache, chills, back
       pain, tightness in
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SOURCE Ortho Biotech Products, L.P.
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