Navigation Links
Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer
Date:12/14/2008

SAN ANTONIO, Dec. 14 /PRNewswire/ -- Results from a Phase 3 study show that patients with metastatic breast cancer who were treated previously with an anthracycline in the adjuvant setting experienced a significant improvement in time to disease progression (TTP) and overall response rates after receiving a combination of DOXIL(R) (doxorubicin HCl liposome injection) and docetaxel as compared to docetaxel alone.

Results from this randomized, parallel-group, open-label, multi-center study were presented today at the 31st Annual San Antonio Breast Cancer Symposium (SABCS). The study included only patients previously treated with anthracyclines who had a disease-free interval of at least one year.

The study found that patients treated with the DOXIL and docetaxel combination had a 35% risk reduction for developing disease progression compared with docetaxel alone (hazard ratio = 0.65; 95% confidence interval [0.55, 0.77]; p=0.000001). There is an almost three-month improvement in median TTP for patients treated with the combination compared with docetaxel monotherapy (9.8 versus 7.0 months, respectively).

The safety profile was consistent with known toxicities of the two agents. Additionally, the incidence of symptomatic cardiac events was 5% in the combination group versus 4% in the monotherapy group (>/= Grade 2 cardiac adverse events). Symptomatic congestive heart failure was reported in 1% of subjects in both groups. Arrhythmia was reported in 4% of the combination group and 3% of the monotherapy group. Protocol-defined LVEF decreases occurred in 5% of subjects in both groups.

"Anthracyclines are active drugs for metastatic breast cancer, but concerns about cardiac toxicity have prevented oncologists from using them in those who received anthracyclines as part of their adjuvant therapy," said Dr. Joseph Sparano, Director of the Breast Evaluation Center at the Montefiore-Einstei
'/>"/>

SOURCE Ortho Biotech Products, L.P.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Major deCODE-led Study Underscores Role of the Brain in Obesity
2. Positive Phase II Study of Paciras EXPAREL(TM) (DepoBupivacaine) in Hernia Repair Presented at the Postgraduate Assembly in Anesthesiology (PGA)
3. InterMune to Report Top-Line Results of Triple Combination Study of ITMN-191 in January 2009
4. Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects
5. AstraZeneca and Targacept Announce Top-Line Results from Phase IIb Study of AZD3480 in Cognitive Dysfunction in Schizophrenia
6. New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia
7. Alexion Reports Positive Results from AEGIS Registration Study of Soliris in Japanese Patients With PNH
8. Neuronetrix Announces Preliminary Alzheimers Study Results at the Society for Neuroscience Conference
9. Rib-X Pharmaceuticals Reports Positive Top-Line Results from Phase 2 Study of Delafloxacin
10. Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Positive Results of Phase III Study of Milnacipran for the Management of Fibromyalgia
11. Research Highlights New Approaches to Prevent Blood Clots in Several High-Risk Patient Populations Including Largest Study Ever to Examine Use of Blood-Thinning Medication in Patients With Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... , Sept. 2, 2014 Redspin, Inc., ... penetration testing services, today released an IT security advisory ... "Today,s healthcare CEOs are presiding over the most ... Daniel W. Berger , Redspin,s President and CEO. ... and their Boards of Directors understand why they need ...
(Date:9/2/2014)... ATLANTA , Sept. 2, 2014  For over a ... show no link between vaccines and autism. But at least ... In a statement , William Thompson ... significant information" linking the MMR vaccine to an increased risk ... of the same data suggests that African American males ...
(Date:9/2/2014)... Calif. , Sept. 2, 2014 /PRNewswire-iReach/ -- ... just recognized as one of the fastest growing ... past few years, the company has undergone significant ... research, late phase global clinical development, anti-viral and ... 2 years, WCCT Global has successfully participated in ...
Breaking Medicine Technology:CDC vaccine scientist admits wrongdoing. 2CDC vaccine scientist admits wrongdoing. 3Contract Research Organization WCCT Global Celebrates Being Named as One of the Fastest Growing Companies in America 2
... SweetSpot Diabetes Care, Inc. has registered their ... Device Data System (MDDS) with the FDA the Company announced ... Sessions meeting in San Diego, CA. With the ... of data from patient diabetes devices to research tools and ...
... Golden Meditech Holdings Limited ("Golden Meditech" or the "Group," ... that the Group has accumulated 754,791 ordinary shares in its ... the open market between December 2010 and March 2011. As ... the issued share capital of CCBC. CCBC is ...
Cached Medicine Technology:Golden Meditech to Increase Stake in NYSE-listed Affiliate -- China Cord Blood Corporation to 39.5% 2
(Date:9/2/2014)... At the world-famous Magic Castle in Hollywood, California, famed ... being the first and only female staff Medium. Throughout the ... female magician to hold such a position. , “I’m deeply ... says Misty Lee. “Even since I was a child, magic ... can fascinate guests in much the same way.” , At ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 QueenBeeTickets.com , ... events, is now stocking James Taylor concert tickets for the ... select U.S. cities from November 1 to the 19th. , ... and again on the 4th of the month. General onsales ... fans are all set to obtain seats for one of ...
(Date:9/2/2014)... the U.S. has led to public debate about whether ... In January, President Obama also publically stated he is ... Despite the recent shift in views toward marijuana, the ... not well understood. , Now a new ... US High School Seniors: A Comparison of Alcohol and ...
(Date:9/2/2014)... Smile Squared, a well-known Buy One, Give One ... US-made toothbrush. For every toothbrush purchased, Smile Squared gives ... was created by my wife and me after volunteering ... President of Smile Squared. “There, we saw children who ... of the same children didn't own a toothbrush. We ...
(Date:9/2/2014)... Tuesday 2 September 2014: The fact that mechanical ... been confirmed by data from the ROPAC registry presented ... Hot Line session by Professor Jolien W. Roos-Hesselink, co-chair ... The registry found that 1.4% of pregnant women with ... baby during pregnancy. , The Registry Of Pregnancy And ...
Breaking Medicine News(10 mins):Health News:Magician Misty Lee is the First and Only Female Staff Medium at Hollywood’s Magic Castle 2Health News:James Taylor Presale Tickets for 10 November Concerts On Sale Today From Trusted Provider QueenBeeTickets.com 2Health News:NYU study compares consequences of teen alcohol and marijuana use 2Health News:NYU study compares consequences of teen alcohol and marijuana use 3Health News:Smile Squared's Colorful Buy One, Give One Toothbrush Now Available in Schnucks Stores 2Health News:Mechanical heart valves increase pregnancy risk 2Health News:Mechanical heart valves increase pregnancy risk 3
... that treats Type-2 diabetes has been shown to prevent ... the growth of breast cancer cells, according to a ... The research, led by pediatrics professor James Trosko ... biological evidence for previously reported epidemiological surveys that long-term ...
... European Science Foundation (ESF) has awarded this year,s European ... Max Planck Institute for Demographic Research in Rostock, Germany. ... Vaupel was awarded the prize for his contributions to ... on demographic research. The Prize was awarded on the ...
... How will the terrorist attacks in Norway on 22 July ... social scientists at the University of Stavanger (UiS). "Norwegians ... Einar Olsen. "These incidents were so extensive and gruesome that ... He is very interested to see what content Norway will ...
... for cancer and epilepsy could also prevent heart attacks, according ... Gothenburg, Sweden, who have been using it to stimulate the ... are normally caused by the formation of a blood clot ... with oxygen and nutrients. The clot reduces the supply of ...
... News) -- Some patients with inflammatory bowel disease may ... their use of immunosuppressant drugs to treat the intestinal ... The studies, published in the November issue of ... commonly used to treat patients with irritable bowel disease, ...
... By Steven Reinberg HealthDay Reporter , TUESDAY, ... "energy" drinks skyrockets, so do related health problems, a ... almost 10 times more cases of reactions to beverages such ... to a new U.S. government report released Tuesday. More ...
Cached Medicine News:Health News:Diabetes drug shows promise in reducing risk of cancer 2Health News:ESF awards 13th European Latsis Prize to James Vaupel on pioneering demographic research 2Health News:Coming to terms with terror 2Health News:Coming to terms with terror 3Health News:Coming to terms with terror 4Health News:Substance in cancer medicine could prevent heart attacks 2Health News:Chronic Bowel Disease Drugs Linked to Skin Cancer Risk 2Health News:ER Visits for Energy-Drink Ills Soar in U.S. 2Health News:ER Visits for Energy-Drink Ills Soar in U.S. 3
... Atlantech's new tibial guide is designed for ... to choose between "point" or "elbow" aimers ... for creation of the tibial tunnel. The ... design features and the reproducibility and accuracy ...
The Pinn-ACL Guide can be used to create tibial tunnels of known lengths with a variable angle adjustment of 35 to 60 degrees with the use of a,graduated pin-sleeve....
Hand surgery basic instrument set...
Hand surgery basic instrument set with round handled instruments...
Medicine Products: