Navigation Links
Study Demonstrates Lexapro(R) Significantly Improves Depression Symptoms in Adolescents
Date:5/7/2008

parallel-group, placebo-controlled phase III study to evaluate the safety and efficacy of Lexapro in the treatment of depressed adolescents, aged 12-17, was conducted in multiple centers across the U.S. A total of 316 patients entered the eight week study, receiving either Lexapro 10-20 mg (n=158) or placebo (n=158). The primary endpoint was change from baseline to Week 8 on the Children's Depression Rating Scale - Revised (CDRS-R) using last observation carried forward (LOCF) approach. The CDRS-R is a commonly used clinician-rated instrument that covers 17 symptom areas of depression relevant to adolescents, including impaired schoolwork, difficulty having fun, social withdrawal, physical complaints, and low self-esteem. The study showed statistically significant improvement in patients treated with Lexapro relative to placebo based on the change from baseline in the CDRS-R score (-22.1 for Lexapro vs. -18.8 for placebo treatment; p=0.022).

The trial also showed that Lexapro was generally well-tolerated. Discontinuation rates due to adverse events were 2.6 percent and 0.6 percent for patients receiving Lexapro and placebo, respectively. Serious adverse events were reported by 2.6 percent of patients receiving Lexapro and 1.3 percent for patients receiving placebo. The most commonly reported adverse events (greater than 10 percent in either group) were headache (25 percent in Lexapro patients vs. 26 percent with placebo), menstrual cramps (11 percent vs. 15 percent placebo), nausea (10 percent vs. 8 percent placebo), insomnia (10 percent vs. 6 percent placebo) and inflicted injury (9 percent vs. 13 percent placebo), the majority of which were accidental in nature. The only adverse event occurring at a frequency of greater than or equal to 5 percent and with an incidence for Lexapro treated patients twice that of placebo treated patients was influenza-like symptoms (7 percent vs. 3 percent placebo).

Depression and Adolescents

Adolescent depressio
'/>"/>

SOURCE Forest Laboratories, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Patients Treated with Risperidone Long-Acting Injection had a Significantly Longer Time to Relapse Compared to Quetiapine in International Clinical Study
2. PEAK Surgical Announces Positive Results From Preclinical Study of PEAK PlasmaBlade(TM) for Obstetric and Gynecologic Surgery
3. New Study Confirms Dose-Accuracy of SoloSTAR(R) Prefilled Insulin Pen
4. Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity
5. QRxPharma Releases Successful Phase 3 Study Results for Dual Opioid Pain Therapy
6. Study Shows Physician Judgment is Important in Reducing Rate of RSV-Related Hospitalizations Among High-Risk Infants
7. Statement From the Lupus Foundation of America Regarding the Release of Top-Line Results From a Study of Rituxan for the Treatment of Lupus
8. Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL
9. Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL)
10. Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C
11. Novagali Pharma Successfully Enrolls First Patient in U.S. Phase I Clinical Study with CORTIJECT(R) for Diabetic Macular Edema
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 20, 2014  The National Association of Drug ... achieved by the real-time, pseudoephedrine (PSE) blocking system ... Log Exchange (NPLEx), automatically blocks unlawful PSE sales ... offenders and make arrests. Data released by NPLEx ... blocked the sale of more than 32,105 ...
(Date:8/20/2014)...  The National Association of Drug Diversion Investigators ... the real-time, pseudoephedrine (PSE) blocking system in Michigan. The ... (NPLEx), automatically blocks unlawful pseudoephedrine sales and helps ... make arrests. Data released by NPLEx shows electronic ... the sale of more than 32,890 boxes of medicine ...
(Date:8/20/2014)... YORK , Aug. 20, 2014 /PRNewswire/ ... research report is available in its catalogue: ... in France, Key Trends and Opportunities to ... Synopsis The report provides in ... the French personal accident and health insurance ...
Breaking Medicine Technology:Indiana's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Michigan's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23
... MASI ) announced today that it will release fourth ... 31, 2011, after the market closes on February 14, 2012. The ... PT (4:30 p.m. ET) and will be hosted by Joe Kiani, ... Vice President and Chief Financial Officer. A live webcast ...
... BEACH, Fla., Jan. 26, 2012 China Nuvo Solar ... name change to SurgLine International, Inc. has been completed ... under the new OTC ticker symbol: SGLN, effective tomorrow, ... owned operating subsidiary of SGLN. Thomas Toland, ...
Cached Medicine Technology:Masimo to Report Fourth Quarter and Full Year 2011 Financial Results After Market Close on February 14, 2012 2Masimo to Report Fourth Quarter and Full Year 2011 Financial Results After Market Close on February 14, 2012 3China Nuvo Solar Energy, Inc. Completes Name Change to SurgLine International, Inc. 2
(Date:8/21/2014)... (PRWEB) August 21, 2014 The results ... today in The Journal of the American Medical Association ... invasive cancers and reduces unnecessary recalls. Memorial Healthcare System ... the study. , “This study confirms what we already ... harmful cancers we want to find and, at the ...
(Date:8/21/2014)... According to a new market report published ... - Home Theatre in-a-box, Home audio systems, Home radios, ... Size, Share, Growth, Trends and Forecast, 2013 - 2019,” ... 2012 and is expected to reach USD 20.68 billion ... 2013 to 2019. Europe was the largest contributor to ...
(Date:8/21/2014)... (HealthDay News) -- In a new review of seafood ... eating tuna due to concerns about mercury exposure. ... only to shrimp as the most commonly eaten seafood ... avoid all tuna," Jean Halloran, director of food policy ... Reports, said in a news release from the group. ...
(Date:8/21/2014)... 2014 Pleio, Inc., a leader ... a new suite of services for retail and ... pharmacy by applying proven behavior shaping programs to ... increased medication adherence, higher PDC scores and improved ... PDC-targeted offerings align retail’s desire to meet health ...
(Date:8/21/2014)... 21, 2014) An international scientific collaboration led by ... alterations that may contribute to a rare form of ... rare cancer but other types as well. , The ... Cancer Genome Atlas initiative , completed the sequence ... today in the journal Cancer Cell . ...
Breaking Medicine News(10 mins):Health News:Dr. Mary Hayes: Study Shows 3D Mammography Finds More Invasive Cancers While Reducing Unnecessary Recalls 2Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 2Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 3Health News:Consumer Reports Advises Pregnant Women to Avoid Tuna 2Health News:Pleio, Inc. Expands Adherence Offerings For Retail Pharmacy 2Health News:Sequence of rare kidney cancer reveals unique alterations involving telomerase 2Health News:Sequence of rare kidney cancer reveals unique alterations involving telomerase 3
... MOUND, Texas, Jan. 16 American,HealthChoice, Inc. (Pink Sheets: ... and Tennessee, today, in an update for Company,shareholders, said ... 2007,totaled $243,000., "It was a year of positioning, ... CEO. "I am updating our shareholders on these,achievements as ...
... Jan. 16 Americans consume more calories as a,nation on ... year, save,Thanksgiving. By the time the final whistle blows at ... from greasy pizza,fried chicken wings, and beer., But this ... length of the,football field 109 times to burn off all ...
... faster with program established in Ottawa, Canada , , WEDNESDAY, ... Ottawa, Canada, designed to rush heart attack patients to ... time it took to perform the potentially lifesaving procedure, ... which a balloon is threaded into a blood vessel ...
... , Ohio Rehabilitation specialists guiding injured workers back ... their assessments and planning, new research suggests. , ... harder time returning to employment if their schedules routinely ... Ohio State University study. Those who work more than ...
... in the lungs of patients diagnosed with idiopathic ... University of Cincinnati (UC) researchers have discovered. , ... neutrophil (pronounced new-tro-fil) cellsa type of white blood ... percent increased risk of mortality in the first ...
... ... Women, ST. LOUIS, ... nearly 2,400 deaths each day,in the United States, an average of one ... percent of the total U.S.,female population, there,s more reason than ever to ...
Cached Medicine News:Health News:American HealthChoice CEO Dr. J.W. Stucki Provides Company Update 2Health News:American HealthChoice CEO Dr. J.W. Stucki Provides Company Update 3Health News:Eat This, Not That!(TM): 5 Smart Super Bowl Swaps That Will Save You Hundreds of Calories 2Health News:Specialized System Speeds Heart Attack Treatment 2Health News:Specialized System Speeds Heart Attack Treatment 3Health News:Extended work hours should factor into return to job after injury 2Health News:Extended work hours should factor into return to job after injury 3Health News:Rare lung disease cells indicate higher death risk 2Health News:Women May Enjoy Boost of Heart Health With Soy 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: