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Study Data Show INTUNIV™ (guanfacine) Extended Release Tablets Co-administered With Stimulants Provided ADHD Symptom Improvement in Children and Adolescents
Date:5/21/2010

d Clinical Global Impressions-Severity of illness scale score of at least three).

About INTUNIV

Once-daily INTUNIV is the first non-scheduled selective alpha-2A agonist for the treatment of ADHD in children and adolescents aged 6 to 17.  INTUNIV was approved in the United States in September 2009 and is available in US pharmacies in four dosage strengths of 1 mg, 2 mg, 3 mg, and 4 mg.  INTUNIV is not a controlled substance and has no known potential for abuse or dependence.

Although it is not known exactly how INTUNIV works, guanfacine, the active ingredient in INTUNIV, has been shown to interact with certain receptors in the part of the brain called the prefrontal cortex (PFC).   Research has shown that behaviors related to ADHD, such as inattention and impulsiveness, may be controlled in this part of the brain.

Additional information about INTUNIV and Full Prescribing Information are available at www.intunivpro.com.

Indication and Important Safety Information

INTUNIV is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents ages 6 to 17.  Efficacy was established in two controlled clinical trials (8 and 9 weeks in duration).  The physician electing to use INTUNIV for extended
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