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Study Confirms that OrbusNeich's Genous™ Stent Effectively Captures Circulating Endothelial Progenitor Cells to Accelerate Re-Endothelialization and Decrease Thrombogenicity
Date:7/11/2011

HONG KONG, July 11, 2011 /PRNewswire/ -- OrbusNeich today announced that data from an ex vivo arteriovenous (AV) shunt model of human circulating blood, in addition to results from three preclinical studies, demonstrated that the Genous Stent effectively captures circulating CD34+ endothelial progenitor cells (EPCs) leading to accelerated re-endothelialization and decreased thrombogenicity compared to bare metal stents (BMS). These mechanistic data were published as an e-publication on the European Heart Journal website.

Data from the ex vivo human AV shunt study showed that EPC deposition on the struts of the Genous Stent was enhanced by 32.5 percent compared to BMS. In addition, the expression of specific endothelial markers increased significantly in cells deposited on the Genous Stent compared to those on the BMS. The data also showed a significant decrease in the expression of thrombotic markers associated with Genous.

"These data demonstrate the effectiveness of the capture of CD34+ cells for endothelialization and the prevention of thrombosis," said Eric J. Duckers, M.D., Ph.D., of the Thoraxcenter at Erasmus University Medical Center in Rotterdam, The Netherlands, and senior author of the publication. "This mechanism of early endothelialization supports the usage of Genous' unique EPC capture technology especially for patients who are at higher risk of thrombosis."

For the ex vivo human study, 15 patients undergoing coronary angiography received an extracorporeal femoral AV shunt containing a Genous Stent and a BMS, which were exposed to circulating blood for up to 120 minutes. The cell depositions on the struts were determined by confocal and scanning electron microscopic analysis (SEM). Expression of endothelial and thrombotic markers was determined using quantitative polymerase chain reaction (qPCR).

"We were able to see a significant difference between the Genous Stent and the bare metal stent in
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