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Study Compares Risk With Two Diabetes Drugs
Date:8/24/2010

DALLAS, Aug. 24 /PRNewswire-USNewswire/ -- In contrast to previous reports, the risks of the composite endpoint of heart attack, heart failure, both, or death were the same – about 4 percent – for patients taking the diabetes drugs rosiglitazone or pioglitazone, according to a study published in the American Heart Association journal Circulation: Cardiovascular Quality and Outcomes.

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"This study provides patients and their doctors with another source of information about rosiglitazone and pioglitazone (sold as Avandia and Actos, respectively) as they determine the best therapy for diabetes patients," said Debra Wertz, Pharm.D., lead author and outcomes research manager at HealthCore, Inc., the research subsidiary of health insurance company WellPoint, Inc.

This study evaluated more than 36,000 diabetes patients. Of the 28,938 patients who were propensity-score matched, a methodology used to provide an estimation of treatment-effects that is as unbiased as possible, 602 patients taking rosiglitazone and 599 taking pioglitazone over a 33-month period suffered either a heart attack, heart failure, both, or died. This translates to about 4 percent of all patients taking either medication. The individual specific adverse events were also not significantly different between the two groups, and were:

  • Heart attack – 96 patients on rosiglitazone and 121 patients on pioglitazone;
  • Heart failure – 265 patients taking rosiglitazone and 243 taking pioglitazone;
  • Heart attack and heart failure – 24 patients on rosiglitazone and 18 on pioglitazone; and
  • Death –
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  • SOURCE American Heart Association
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