Study Compares Bronchodilatory Effects of SYMBICORT(R) and Advair in Adults W... ( Data Showed Faster Onset with SYMBIC...)

Study Compares Bronchodilatory Effects of SYMBICORT(R) and Advair in Adults With Asthma

Date:3/18/2008

Data Showed Faster Onset with SYMBICORT with Improved Lung Function within

3 and 15 Minutes

WILMINGTON, Del., March 18 /PRNewswire-FirstCall/ -- Data from a new study demonstrated that the combination asthma maintenance therapy, SYMBICORT(R) (budesonide/formoterol fumarate dihydrate), provided greater and faster bronchodilatory effects, or opening of the airways, compared with Advair (fluticasone propionate/salmeterol) in adults with mild to moderate asthma. In addition, these data demonstrated that SYMBICORT provided a similar bronchodilatory response to albuterol. Bronchodilatory response is defined as the mean time to achieve improvement in lung function. The results from the two studies were presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting held in Philadelphia, March 14-18, 2008.

"SYMBICORT is a combination of two proven asthma medications - budesonide and formoterol. It reduces inflammation experienced on a chronic basis to help patients breathe easier and offers fast action, dose after dose, for bronchodilation (or opening of the lungs)," said lead investigator Frank C. Hampel, Jr., MD, Central Texas Health Research, New Braunfels, Texas.

In both studies, bronchodilatory response was measured by the mean improvements in forced expiratory volume in one second (FEV1) - how much air a person can exhale during a forced breath in the first second of exhalation, which is a measure of airway function and can be reduced with airway obstruction. Assessments were made at multiple time points over 12 hours including those at three minutes and 15 minutes after the medication was taken.

"SYMBICORT works quickly to improve airflow within 15 minutes, helping patients to breathe better throughout the day and night," said Philip Silkoff, MD, Medical Science, AstraZeneca. "It's important for patients, whose doctors have prescribed a daily maintenance medication to control inflammatio
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