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Studies Show Effect of BYDUREON™ on A1C and Weight for Up to Three Years
Date:6/24/2011

l controlled period (27 percent) and the incidence decreased to 16 percent from week 30 to week 156. No major hypoglycemia was observed.

DURATION-3 (277-OR)
Oral Presentation – Monday, June 27, 9-9:15 a.m.
Of the patients enrolled in the DURATION-3 study, 390 entered the open-label, comparator-controlled extension study after 26 weeks of treatment with either BYDUREON or Lantus, and 173 patients in each treatment group completed the 84-week extension. A similar proportion of patients in each treatment group achieved the study endpoint of A1C less than 7 percent (BYDUREON: 45 percent; Lantus: 37 percent; p=0.084). However, a higher proportion of patients on BYDUREON achieved A1C less than or equal to 6.5 percent compared to those on Lantus (BYDUREON: 31 percent; Lantus: 20 percent; p=0.009).

BYDUREON was well tolerated during the treatment period. The most common adverse event was nasopharyngitis in both treatment arms, as well as nausea in the BYDUREON group and headache in the Lantus group. Patients taking BYDUREON reported significantly fewer episodes of confirmed hypoglycemia.

About Diabetes

Diabetes affects nearly 26 million people in the U.S. and an estimated 285 million adults worldwide.(i,ii) Approximately 90-95 percent of those affected have type 2 diabetes. Diabetes costs more than $174 billion per year in direct and indirect medical expenses.(iii)

According to the Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey, approximately 60 percent of people with diabetes do not achieve their target blood sugar levels with their current treatment regimen.(iv) In addition, 85 percent of type 2 diabetes patients are overweight and 55 percent are considered obese.(v) Data indicate that weight loss (even a modest amount) supports p
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SOURCE Amylin Pharmaceuticals, Inc.; Eli Lilly and Company; Alkermes, Inc.
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