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Studies Show Effect of BYDUREON™ on A1C and Weight for Up to Three Years
Date:6/24/2011

iabetes as a life-long disease marked by the relentless worsening of glucose control, many patients and their physicians struggle to find treatments that help control blood sugar over time," said Christian Weyer, M.D., senior vice president, research and development, Amylin Pharmaceuticals. "In these extension studies, patients using BYDUREON for several years showed an improvement in glycemic control, with weight loss, with just one dose per week."

BYDUREON is the proposed brand name for exenatide extended-release for injectable suspension. It is an investigational medication for type 2 diabetes designed to deliver continuous therapeutic levels of exenatide in a single weekly dose. BYDUREON is a once-weekly formulation of exenatide, the active ingredient in BYETTA® (exenatide) injection, which has been available in the U.S. since June 2005 and is used in more than 70 countries worldwide to improve glycemic control in adults with type 2 diabetes. BYDUREON received marketing authorization in the European Union earlier this month.

Study and Presentation Details (All Times Pacific Daylight Time)

DURATION-1 (969-P)
General Poster Presentation – Saturday, June 25, 11:30 a.m. to 1:30 p.m.
Audio Poster Tour – Monday, June 27, 12-1 p.m.
The 30-week controlled portion of the DURATION-1 trial, which compared the efficacy of BYDUREON to BYETTA, was followed by an open-ended extension period in which all patients either continued treatment with BYDUREON or switched from BYETTA to BYDUREON. Approximately 64 percent (n=194) of the 295 intent-to-treat patients completed three years of treatment, 57 percent of whom achieved an A1C 7 percent or below. BYDUREON was well tolerated throughout the treatment period. Nausea was the most common adverse event during the initia
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SOURCE Amylin Pharmaceuticals, Inc.; Eli Lilly and Company; Alkermes, Inc.
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