Navigation Links
Studies Point to Benefits of Personalized Chemotherapy Dose Management in Colorectal Cancer
Date:5/2/2008

BETHLEHEM, Pa., May 2 /PRNewswire/ -- Can a blood test improve treatment outcomes for colorectal cancer patients? Recently published studies indicate that personalized chemotherapy dose management -- measuring drug levels in patients' blood and adjusting them for optimal dosing -- can substantially reduce severe toxicity and improve efficacy in colorectal cancer.

A Phase III randomized study of 208 colorectal cancer patients, by Erick Gamelin, M.D., Ph.D. et. al., was published in the May 1 issue of the Journal of Clinical Oncology (JCO). It found that metastatic colorectal cancer patients whose dose of 5-fluorouracil (5-FU) was personalized based on results of regular blood tests experienced reduced severe toxicities and nearly doubled response rates compared to patients who received standard 5-FU dosing based on body surface area. Additionally, patients who received personalized dosing experienced a 48 percent relative improvement in survival at two years. 5-FU is the cornerstone chemotherapy in most treatment regimens for this type of cancer.

The current standard-of-care in dosing 5-FU is based on body surface area (BSA) and is calculated using patients' height and weight. In the JCO study, personalized dosing was based on blood tests to measure the actual level of the drug. The study demonstrated that only 25 percent of colorectal cancer patients achieved optimal chemotherapy blood levels when dosed by BSA. Seventeen percent of the BSA-dosed patients received toxic levels of the drug, while 58 percent were under-dosed.

The JCO study, "Individual 5-fluorouracil dose adjustment based on pharmacokinetic follow-up compared with conventional dosage: Results of a multicenter randomized trial of patients with metastatic colorectal cancer," evaluated patients being treated with 5-FU in combination with leucovorin. Half of the patients were dosed with 5-FU based on BSA. The other half were initially dosed based on BSA, with subsequent cycle do
'/>"/>

SOURCE Saladax Biomedical
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Rigels R788 Slows Progression of Murine Lupus in Preclinical Studies
2. Sunesis Pharmaceuticals Reports Data from Nonclinical Studies of SNS-032 at the Annual Meeting of the American Association for Cancer Research
3. Novavax Reports Positive Results from Preclinical Studies of its VLP-based Trivalent Seasonal Influenza Vaccine Candidate
4. Mayo Clinic Studies Find REM Sleep Behavior Disorder is Associated with Other Features of Neurodegenerative Disorders
5. Medarex Reports Interim Data from Ongoing Ipilimumab Combination Phase 1 Studies in Prostate Cancer at American Association for Cancer Research Meeting
6. Halozyme Therapeutics Presents Pre-Clinical Studies of Systemic Delivery of Pegylated rHuPH20 Enyzme in Prostate Cancer Models at American Association for Cancer Research Conference
7. Micromet Presents Safety and Efficacy Data from Primate Studies With Two New BiTE Antibodies Developed for Treatment of Leukaemia and Melanoma
8. BSI-201 Demonstrates Significant Tumor Growth Inhibition and Increased Survival Rates in Preclinical Ovarian Cancer Studies
9. Independent Studies Report on Possible Roles for Cylexs Immune Cell Function Assay in Monitoring of Heart and Lung Transplant Recipients
10. Nektar Terminates All Negotiations With Potential Partners for Inhaled Insulin; Increased Number of Lung Cancer Cases Observed in Ongoing Clinical Studies of Inhaled Insulin Patients
11. Data From Ortho Biotech-Sponsored Studies to be Presented at National Kidney Foundation 2008 Spring Clinical Meetings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... , April 20, 2015  Sigma-Aldrich Corporation ... Corporate Responsibility (CR) Magazine,s list of the 100 ... on outstanding corporate responsibility performance.  Sigma-Aldrich ranked fifth, ... appearance on the list. "We are ... corporate responsibility efforts and we are extremely pleased ...
(Date:4/20/2015)... The preclinical contract research organization Absorption Systems ... safety testing of medical devices, announces that its Chief Scientist, ... " Drug Transporters in ADME: From the Bench to the ... title of Dr. Hidalgo,s talk is "Modern Tools for the ... Tools of the Future." The workshop, organized jointly ...
(Date:4/20/2015)...  Ameritox,s Ingenuity Health, a leading provider of monitoring ... at the National Council of Behavioral Health annual conference ... nearly 25 percent of the samples collected from patients ... prescribed antipsychotic medication. ... Medication nonadherence ...
Breaking Medicine Technology:Sigma-Aldrich Named to CR Magazine's 100 Best Corporate Citizens List 2Absorption Systems Chief Scientist Ismael Hidalgo to Present at International Workshop on Drug Transporters 2Ingenuity Health Research Flags Potentially High Rate of Medication Nonadherence Among Those with Serious Mental Illness 2Ingenuity Health Research Flags Potentially High Rate of Medication Nonadherence Among Those with Serious Mental Illness 3
... FOREST, Ill., April 11, 2011 PharMEDium Healthcare Corporation ... of Anesthesiologists (ASA), as a part of a new ... practice management companies. David N. Jonas, PharMEDium ... ASA,s efforts to advance the anesthesiology field through leadership, ...
... In response to Thursday,s Medicare Payment Advisory ... substantially higher levels of advanced diagnostic imaging services ... approval before being able to provide those services, ... instead look to existing clinical decision support tools ...
Cached Medicine Technology:PharMEDium Becomes a Corporate Supporter of the American Society of Anesthesiologists (ASA) 2Healthcare Providers, Technology Experts Call for Use of Existing Decision Support Tools to Promote Diagnostic Imaging Appropriate Use 2Healthcare Providers, Technology Experts Call for Use of Existing Decision Support Tools to Promote Diagnostic Imaging Appropriate Use 3
(Date:4/21/2015)... Angeles, CA (PRWEB) April 21, 2015 ... power score of 3.8 out of 5, indicating generally ... due to its low barriers to entry and the ... are only moved relatively short distances,” says IBISWorld research ... scattered throughout the country, typically serving local and regional ...
(Date:4/21/2015)... 21, 2015 As nationally recognized ... in various components of breast reconstruction research spanning ... , "Breast reconstruction research continues to significantly contribute ... recent advances, many unanswered questions remain requiring continuous ... optimal results," says Dr. Oscar Ochoa emphasizing the ...
(Date:4/21/2015)... The Northeast Football Clinic (NEFC) has ... prep school in Byfield, MA. Applications are being accepted ... entering grades 6-12. , The outstanding professional, college, and ... coaching. , Offensive and defensive linemen and ... the most unsung positions on the field, the the ...
(Date:4/21/2015)... 2015 Freeslate, Inc ., the ... today announced that the Centre for Catalysis Research ... has acquired a Freeslate Core Module 3 (CM3) ... (SPR) to accelerate current research programs. The systems ... they will be available to academic users and industrial ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 This ... pathologists, physical therapist assistants, occupational therapist assistants, teachers, ... and techniques to help children across the autism ... through Education Resources Inc. , ... 2008, this highly acclaimed yoga curriculum addresses learning ...
Breaking Medicine News(10 mins):Health News:Bulk Food-Grade Transportation Services Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Bulk Food-Grade Transportation Services Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Research Performed at PRMA Expands Breast Reconstruction Knowledge 2Health News:Research Performed at PRMA Expands Breast Reconstruction Knowledge 3Health News:Research Performed at PRMA Expands Breast Reconstruction Knowledge 4Health News:Research Performed at PRMA Expands Breast Reconstruction Knowledge 5Health News:US Sports Camps and The Northeast Football Clinic Announce 2015 Lineman/Linebacker Clinic Schedule 2Health News:University of Ottawa Selects Freeslate Reaction Screening System to Support High-Throughput Research at the Centre for Catalysis Research and Innovation 2Health News:University of Ottawa Selects Freeslate Reaction Screening System to Support High-Throughput Research at the Centre for Catalysis Research and Innovation 3Health News:ABC News Interviews Anne Buckley-Reen, Education Resources Inc. Faculty Member, on Yoga Therapy in the Classroom 2
... and pediatricians have relied on humid air to relieve the ... condition that sometimes// sends worried families to the emergency room. ... relied-on remedy has little medical benefit. ,“Typically you ... the bathroom. Or you get them to boil a kettle ...
... by most major medical associations, including the American Academy of ... , More than nine in 10 doctors who are taught ... consideration before circumcising a baby boy; compared with only seven ... survey shows that 97 percent of these doctors now learn ...
... IV antibiotic that can be used for the treatment ... by antibiotic// resistant bacteria such as methicillin-resistant Staphylococcus aureus ... today. Availability of this new antibiotic comes at a ... greater than ever and clinicians are running out of ...
... Meeting of SNM in San Diego witnessed a meeting ... imaging and nuclear medicine branch// and this meeting was ... ,“SNM continues to successfully offer a unique ... new and evolving aspects of nuclear medicine and molecular ...
... from the civic hospitals on Friday have indicated that ... and other rain-related ailments,// taking the death toll in ... officials have claimed that additional precautions have been taken ... including Kurla and parts of Malad. The earlier reports ...
... is being launched in Australia to help men manage ... so that men who are diagnosed// every year have ... (NBCC) maintains the website. ,It was explained ... with the condition. Alison Evans, from the National Breast ...
Cached Medicine News:Health News:Humid Air is Little Help for Croup's Barking Cough 2Health News:Humid Air is Little Help for Croup's Barking Cough 3Health News:Pain Relief During Circumcision 2Health News:Broad Spectrum Antibiotic Available for Antibiotic Resistant Bacteria 2Health News:SNM recognizes exemplary contributors in nuclear medicine 2Health News:Monsoon Related Diseases On The Rise In Mumbai 2
... Centuries of German Craftsmanship ... instrumentation in the world. Ocutek® ... you! Only holders of the ... and eight-year apprenticeship, are qualified ...
... Endoscopic CycloPhotocoagulation (ECP) is a surgical ... endoscopy and visualized laser application. The ciliary ... by the surgeon, from the anterior or ... time. The target tissues are easily and ...
... a surgical approach to glaucoma management that ... The ciliary body (which produces aqueous humour) ... anterior or posterior segment, through the endoscope ... easily and accurately identified utilizing endoscopy. This ...
... (ECP) is a surgical approach to glaucoma ... laser application. The ciliary body (which produces ... from the anterior or posterior segment, through ... tissues are easily and accurately identified utilizing ...
Medicine Products: