Navigation Links
Studies Investigate New Methodologies to Improve Recovery and Survival Strategies for Patients Undergoing Hematopoietic Cell Transplantation
Date:12/10/2011

ffect. Recognizing this challenge, researchers sought to create a new method to suppress GVHD without compromising the GVT effect by using genetically engineered donor T-cells that over-express a protein known to induce cell death in an effort to specifically attack cancer cells.

The protein, Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand, or TRAIL, is naturally expressed on some immune cells in the body. TRAIL targets tumor cells and keeps them from multiplying and spreading by interacting with death receptor molecules, which are highly expressed on the surface of tumor cells, making them more susceptible to therapeutic targeting using TRAIL.

To evaluate the effect of genetically engineered donor T-cells over-expressing TRAIL (TRAIL+) on GVHD and GVT, investigators from Memorial Sloan-Kettering Cancer Center performed HCT using TRAIL+ donor T-cells versus control donor T-cells in experimental mouse models with cancerous tumors. Mice that received TRAIL+ donor T-cells displayed significantly higher survival rates, indicating greater antitumor activity than in those treated with control donor T-cells. The researchers also used donor TRAIL+ progenitor T-cell with autologous (stem cells from the patient) HCT in tumor-bearing mice and found a significantly higher anti-tumor effect compared with controls. In addition to enhanced GVT effect, the transplant recipients treated with TRAIL+ T-cells experienced significantly less severe GVHD. Researchers further found that the immune cells, which trigger GVHD, also express TRAIL-sensitive death receptors, and TRAIL+ T-cells can suppress GVHD by targeting these cells.

"Our data show that donor T-cells over-expressing TRAIL can suppress GVHD while simultaneously enhancing the GVT effects. We hope this approach will provide fresh insights into separating cancer cell killing from indiscriminate killing of normal tissues," said Arnab Ghosh, MD, PhD, lead author and a Research Scholar in the lab
'/>"/>

SOURCE American Society of Hematology
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Bayers Drospirenone-containing Combination Oral Contraceptives: FDA Advisory Committees Affirm Positive Benefit-risk Profile and Recommend an Update of Labels to Reflect Information From Available Studies
2. Genomic Health Announces Presentation of Sixteen Oncotype DX Studies at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium
3. Montage Announces Three More Hospitals Implement Their On-Demand Search and Data Mining Technology for Radiology Studies
4. Sustained Viral Response from Phase 2 Studies of BI 201335, Including Difficult-to-Treat HCV Patient Types
5. Isis Initiates Phase 1 Studies with Isis-GCGRRx and Isis-GCCRRx to Treat Type 2 Diabetes
6. Data From Phase 2 Clinical Studies of Telotristat Etiprate in Patients With Carcinoid Syndrome to be Presented at North American Neuroendocrine Tumor Society Meeting
7. New Clinical Studies Presented at the American Society of Anesthesiologists Annual Meeting Show Benefits of Masimo Noninvasive Technologies: SpHb, PVI, RRa, and SEDLine
8. Inovio Pharmaceuticals and VGX International to Advance Therapeutic Hepatitis C and Hepatitis B Synthetic Vaccines into Clinical Studies
9. Managing Bioequivalence Studies to Optimize the Quality, Cost, and Speed of Generics Manufacturing
10. FDA Seeks Comment on Proposed Guidelines for High-Quality Clinical Studies
11. Urgent® PC Clinical Studies Results Scheduled for Presentation at International Continence Society
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... 2015  Effective staffing of key marketing services ... success. Research and consulting leader ... pharmaceutical and biotech marketing managers with metrics detailing ... are being channeled into marketing operations of global ... utilize this report to benchmark their own resource ...
(Date:5/22/2015)... Texas , May 22, 2015 ... million in 2014 and is estimated to reach $90.7 million ... 2019. Browse through the TOC of North America ... segments, with the help of various tables and figures. ... receive 10% customization on this report.   ...
(Date:5/22/2015)... WASHINGTON , May 22, 2015  The ... certain diagnosed victims of mesothelioma get the best ... making certain individuals with this rare cancer caused ... the most up-to-date information related to treatment options ... information please call the Mesothelioma Victims Center anytime ...
Breaking Medicine Technology:Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 2North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 5
... Va., June 3, 2011 Patient Advocate Foundation (PAF) is ... contribution enabling it to begin offering support to patients ... its Co-Pay Relief Program (CPR) on June 6, 2011 ... organization that seeks to safeguard patients through effective mediation ...
... ANTONIO, June 3, 2011 At the 2011 ... #6033) will address the increasing demand for molecular imaging ... in three directions: patient access, clinical utilization, and new ... Siemens (NYSE: SI ) is ...
Cached Medicine Technology:Patient Advocate Foundation Announces Additional Support for Patient Co-Pay Relief Program Serving Nonsquamous Non-Small Cell Lung Cancer (NSCLC) Patients 2Siemens Expands Customer Return on Innovation at SNM 2011 2Siemens Expands Customer Return on Innovation at SNM 2011 3Siemens Expands Customer Return on Innovation at SNM 2011 4
(Date:5/25/2015)... According to a recently published report by iData ... fixation market is driven by an increase in fractures ... infection prevention technologies. As the population ages, prevalence of ... the largest total number of bone fixation procedures in ... a result, the average selling price (ASP) of hip ...
(Date:5/25/2015)... Join Fiona's Soccer Camp at Novato High School's ... Irish National Player, Fiona O'Sullivan will be on site to ... her coaching style. Fiona has three camps running this summer ... at Lynwood Elmentary School (June 15-19) and Hill Recreation Center ... 6th, 2015 - 1:00-3:00pm. Bring a Soccer Ball, Cleats and ...
(Date:5/24/2015)... 25, 2015 Pacific Prime has announced that they ... looking at the cost of individual international health insurance. Titled: ... looks at the cost of health insurance in six top expat ... Hong Kong , Singapore , ... UAE , the UK , Article 2 ...
(Date:5/24/2015)... (PRWEB) May 24, 2015 Scientists with ... paper on air quality compliance issues that may have ... workers. Surviving Mesothelioma has just posted an article on ... , The group found airborne asbestos levels well ... collected between 1984 and 2011. , “Asbestos compliance sampling ...
(Date:5/24/2015)... Scottsdale, Arizona (PRWEB) May 24, 2015 ... hired former Millennial Media strategy executive Jay Krihak ... as Medicx looks to ramp up its expertise ... services of the Pharmaceutical and Health sectors. , ... ad tech executive. Most recently, Krihak led sales ...
Breaking Medicine News(10 mins):Health News:DePuy Synthes and Stryker Lead Orthopedic External Fixation Trauma Device Market Due to Increased Hip Fractures in the U.S. 2Health News:DePuy Synthes and Stryker Lead Orthopedic External Fixation Trauma Device Market Due to Increased Hip Fractures in the U.S. 3Health News:US Sports Camps and Nike Soccer Camps Offer Complimentary Instructional Clinic with Fiona's Soccer Camp 2Health News:Pacific Prime Releases 2nd Article of Cost of Health Insurance Report 2Health News:New Analysis Finds Too Many Employers Ignored OSHA Asbestos Guidelines, According to Surviving Mesothelioma 2Health News:Medicx Media Solutions Expands Executive Team 2
... March 25 Universal Benefit Plans--a Boston based, ... today that they will offer of a comprehensive ... no charge. Through their affiliate organization, Leggette Actuaries, ... COBRA notification, tracking and billing responsibilities for their ...
... write about benefits of running; top essayists honored at ... Financial services leader ING today selected three winners ... their accomplishments as participants in the ING Run For ... schools.The top three essays were submitted by the following ...
... Highly regarded Orange County plastic surgeon, Dr. Michael Niccole says there ... non-surgical treatments while taking time to research and do the homework ... ... Newport Beach, CA (PRWEB) March 25, 2009 -- Adapting one,s priorities ...
... in French . , A collaborative study ... University has demonstrated a positive link between cognitive ability and ... year olds. The correlation is evident in regions that integrate ... published this week in a special issue of scientific journal ...
... to announce the receipt of their official IRS determination letter. , ... ... ) is thrilled to announce the receipt of their official IRS determination ... serves and supports therapeutic massage and spa services for cancer patients ...
... urges new role in coordinating, funding local prevention efforts ... from private, nonprofit groups calls on the U.S. government ... mental health of the nation,s youth. , The ... asking President Barack Obama to create a new agency ...
Cached Medicine News:Health News:Universal Benefit Plans Teams up with Leggette Actuaries to Offer Free COBRA Services to New Clients 2Health News:ING Names Winners of 'ING Run For Something Better' Student Essay Contest 2Health News:ING Names Winners of 'ING Run For Something Better' Student Essay Contest 3Health News:ING Names Winners of 'ING Run For Something Better' Student Essay Contest 4Health News:ING Names Winners of 'ING Run For Something Better' Student Essay Contest 5Health News:Orange County Plastic Surgeon Warns: When It Comes To The Face And Body, The Best Deal Could Cost More 2Health News:When it comes to intelligence, size matters 2Health News:Angie's Spa Receives Official Acknowledgment of Non-Profit Status 2Health News:U.S. Asked to Do More for Kids' Mental Health 2Health News:U.S. Asked to Do More for Kids' Mental Health 3
Xsera Rapid HIV-1/2 Antibody Controls are unassayed positive and negative quality control materials used for monitoring the performance of qualitative rapid HIV-1 and HIV-2 test kits....
... a CLIA-certified diagnostic laboratory specializing in salivary ... number of other analytes in support of ... States. We also offer a diverse ... pre-clinical trials services. Our clients include ...
For the qualitative detection of igG antibodies specific to Helicobacter pylori in human serum, plasma and whole blood specimens...
For the qualitative detection of Infectious mononucleosis IgM heterophile antibodies in human whole blood, serum and plasma specimens....
Medicine Products: