Navigation Links
Studies Investigate New Methodologies to Improve Recovery and Survival Strategies for Patients Undergoing Hematopoietic Cell Transplantation
Date:12/10/2011

ells taken from the bone marrow.

PBSCs are stem cells originally found in the bone marrow that have been moved, or mobilized, into the blood stream by a special drug regimen. Unlike bone marrow stem cells, which must be extracted from the bones in an operating room, PBSCs are more easily obtained through apheresis, a process similar to regular blood donation, which collects the PBSCs through a tube inserted in a vein. A critical step before the transplant is to find a donor that is tissue matched to the recipient.

About one-third of patients who need a PBSC or bone marrow transplant for treatment of a blood disease have a matched, related donor. According to the National Marrow Donor Program, of the 70 percent who cannot find a donor within their family, most will be able to find an unrelated donor. Since the majority of transplant patients ultimately receive cells from unrelated donors, there is a need to better understand the risks associated with transplants of unrelated donor cells.

Previous clinical trials on related donor transplants have demonstrated that PBSC transplants in patients with leukemia and other blood diseases result in better engraftment, lower relapse rates, and increased survival compared to transplants with bone marrow stem cells. However, those trials also found that PBSC transplants carry an increased risk of GVHD, a serious and often deadly post-transplant complication that occurs when the newly transplanted donor cells recognize the recipient's own cells as foreign and attack them. Patients who survive early post-transplant may develop chronic GVHD, a disabling condition managed with long-term immunosuppressant therapy.

Many transplant centers are increasingly using PBSCs as a source for adult stem cells because of their superiority in clinical trials that have directly compared outcomes between PBSCs and bone marrow stem cells from related donors. However, to date, there has not been a comparative study of the
'/>"/>

SOURCE American Society of Hematology
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Bayers Drospirenone-containing Combination Oral Contraceptives: FDA Advisory Committees Affirm Positive Benefit-risk Profile and Recommend an Update of Labels to Reflect Information From Available Studies
2. Genomic Health Announces Presentation of Sixteen Oncotype DX Studies at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium
3. Montage Announces Three More Hospitals Implement Their On-Demand Search and Data Mining Technology for Radiology Studies
4. Sustained Viral Response from Phase 2 Studies of BI 201335, Including Difficult-to-Treat HCV Patient Types
5. Isis Initiates Phase 1 Studies with Isis-GCGRRx and Isis-GCCRRx to Treat Type 2 Diabetes
6. Data From Phase 2 Clinical Studies of Telotristat Etiprate in Patients With Carcinoid Syndrome to be Presented at North American Neuroendocrine Tumor Society Meeting
7. New Clinical Studies Presented at the American Society of Anesthesiologists Annual Meeting Show Benefits of Masimo Noninvasive Technologies: SpHb, PVI, RRa, and SEDLine
8. Inovio Pharmaceuticals and VGX International to Advance Therapeutic Hepatitis C and Hepatitis B Synthetic Vaccines into Clinical Studies
9. Managing Bioequivalence Studies to Optimize the Quality, Cost, and Speed of Generics Manufacturing
10. FDA Seeks Comment on Proposed Guidelines for High-Quality Clinical Studies
11. Urgent® PC Clinical Studies Results Scheduled for Presentation at International Continence Society
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... 2015 More than a third of reproductive-aged women enrolled ... private insurance, filled a prescription for an opioid pain medication ... week,s Morbidity and Mortality Weekly Report (MMWR). ... moderate to severe pain.  They are also found in some ...
(Date:1/23/2015)... , Jan. 23, 2015  Pete Rose, baseball,s all-time hits ... and arthritis pain reliever Myoflex, Ducere Pharma has announced. ... we are excited to have him on board with Myoflex," ... "He is a legendary player who is known across all ...
(Date:1/23/2015)... Fla. , Jan. 23, 2015  iMD Companies, Inc. (ICBU) ... to increase market share and grab a foothold in the ... influence, production capabilities and a presence in the sector, and ... facilitate the growth of hemp and medical marijuana, iMD is ...
Breaking Medicine Technology:Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3Pete Rose bets on Myoflex to relieve aches and pains 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2
... blood,pressure, reduces blood flow in the brains of adults ... at the annual meeting of,the Radiological Society of North ... of Alzheimer,s disease, our study,shows that it is another ... effects of the disease," said study co-author Cyrus Raji, ...
... 28 Immunosyn,Corporation (OTC Bulletin Board: IMYN) today ... MHRA to import base material,and manufacture SF-1019 for ... for which Immunosyn holds the exclusive license for,worldwide ... Regulatory Agency," more,commonly known as the MHRA, functions ...
Cached Medicine Technology:High Blood Pressure May Heighten Effects of Alzheimer's Disease 2Immunosyn Announces Biozyme Lab's Receipt of MHRA Manufacturing License Approval in Europe for the Biopharmaceutical SF-1019 2Immunosyn Announces Biozyme Lab's Receipt of MHRA Manufacturing License Approval in Europe for the Biopharmaceutical SF-1019 3
(Date:1/23/2015)... January 23, 2015 Hastings and Hastings, a ... reports a record number of legal representation client review requests ... has been a steady rise in the number of slip ... at home throughout the Valley. With that said, a large ... reviewed by an experienced law firm. Hastings and Hastings is ...
(Date:1/22/2015)... January 22, 2015 The City of West Hollywood ... a.m., to commemorate the 42nd anniversary of the Supreme Court decision ... “It’s been 42 years since the Roe vs. Wade decision and ... as present as ever,” said City of West Hollywood Councilmember Abbe ...
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method put ... muscle by up to 30lbs in less than 12 weeks ... Stan Stevenson, prompting an investigative review. , “Our Incredible ... diet formula that allows the body to pack on a ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
(Date:1/22/2015)... January 22, 2015 Carinsurancesavings.biz has released a ... death and dismemberment insurance . , Purchasing an accidental ... be very advantageous. This type of rider provides benefits if ... can be considered a lesser form of life insurance. ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2
... addictive behavior is linked to risk-taking, too, study ... The thrill-seeking behavior that makes people love skydiving, ... in an area of the brain that has ... Kentucky and Purdue University researchers studied volunteers who ...
... When drugs don,t work and surgery is not possible, transplanting stem ... for the treatment of this chronic disease. , ... where total remission of the disease has been shown in 80% ... remaining 20% of cases. Since August 2008, Hospital Clnic has used ...
... Hospital and Salvation Army Receive Top Awards In January; Additional ... Fight Against Breast Cancer and Wounded WarriorsWHITE PLAINS, N.Y., Feb. ... change appear to have extended all the way to online ... to IWON.com last month to play games on behalf of ...
... Inspected Pennsylvania Facilities Meet Federal StandardsHARRISBURG, Pa., Feb. ... reports today showing that all of the 90 ... of 2008 are operating within the guidelines set ... inspects each of Pennsylvania,s approximately 400 certified mammography ...
... be held April 27-29, 2009 at the World Trade Center in Boston, ... as the premier event showcasing the myriad applications of IT and informatics ... the perfect place to share ideas and innovation through networking, education, and ... ...
... MYL ) today announced that its Vice Chairman and ... Market opening on Friday, Feb. 20 from 9:15 to 9:30 ... the company,s switch from The New York Stock Exchange (NYSE) ... 2008. The company is listed on the NASDAQ Global Select ...
Cached Medicine News:Health News:Thrill-Seekers' Brains May Be Wired Differently 2Health News:New therapy with stem cells to treat Crohn's disease 2Health News:New therapy with stem cells to treat Crohn's disease 3Health News:New therapy with stem cells to treat Crohn's disease 4Health News:New therapy with stem cells to treat Crohn's disease 5Health News:Casual Gamers Join Forces With Top Charities to Compete for IWON.com Cash Prizes 2Health News:Casual Gamers Join Forces With Top Charities to Compete for IWON.com Cash Prizes 3Health News:PA DEP Releases Quarterly Mammography Inspections 2Health News:PA DEP Releases Quarterly Mammography Inspections 3Health News:PA DEP Releases Quarterly Mammography Inspections 4Health News:Cambridge Healthtech Institute's 7th Annual Bio-IT World Conference & Expo Enabling Technology - Leveraging Data - Transforming Medicine 2Health News:Cambridge Healthtech Institute's 7th Annual Bio-IT World Conference & Expo Enabling Technology - Leveraging Data - Transforming Medicine 3Health News:Mylan Vice Chairman and CEO Robert J. Coury to Ring NASDAQ Stock Market Opening Bell 2