Navigation Links
Stroke Study Reveals a Key Target For Improving Treatment
Date:6/22/2008

Research in mice shows why tPA carries risks as well as benefits, and suggests that Gleevec or other drugs could prevent problems

ANN ARBOR, Mich., June 22 /PRNewswire-USNewswire/ -- For over a decade, the drug called tPA has proven its worth as the most effective emergency treatment for the most common kind of stroke. But its promise is blemished by two facts: tPA can cause dangerous bleeding in the brain, and its brain-saving power fades fast after the third hour of a stroke.

Now, a new paper published online in Nature Medicine reveals why tPA has these limitations. It also gives tantalizing evidence about how those problems might be overcome, if a stroke victim first takes a drug currently used to treat leukemia.

The researchers, from the University of Michigan and the Ludwig Institute for Cancer Research (LICR) Stockholm Branch at Karolinska Institutet in Stockholm, Sweden, emphasize that it's still too early to apply their findings -- made in mice -- to the treatment of stroke victims everywhere.

But the LICR-Karolinska Institutet team will soon begin a clinical trial to test the theory in humans, using the leukemia drug known as imatinib (Gleevec). In mice, that drug greatly reduced bleeding, even if tPA wasn't given until five hours after a stroke began.

The new paper details a series of molecular and cellular experiments conducted by the two teams, which began collaborating after hearing of each other's work.

They report that tPA apparently causes its risk of bleeding, and leakage of fluid within the brain, by accident. The culprit: tPA's tendency to act upon a protein called PDGF-CC, and the PDGF-alpha receptor that it binds to. This interaction causes the usually impervious "blood-brain barrier" to become porous, leading to leakage. Gleevec inhibits the PDGF-alpha receptor, apparently counteracting tPA's effect.

This unwanted effect on the blood-brain barrier appears to be unrelated to tPA's main job,
'/>"/>

SOURCE University of Michigan Health System
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
2. International Expert Group Initiates Largest Multi-center Phase III Trial to Evaluate NeuroAid(TM) in Stroke Recovery
3. Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ischemic Stroke
4. FASgen Announces New Discovery for Treatment of Stroke
5. ImaRx Provides Update on TUCSON Phase I/II Clinical Trial in Acute Ischemic Stroke
6. Fifth DSMB Meeting Supports Neurobiological Technologies Continuation of Phase 3 Stroke Trials With Viprinex(TM) (ancrod)
7. Neurobiological Technologies, Inc. Presents Dosing Rationale for Viprinex(TM) (ancrod) at the European Stroke Conference
8. PRoFESS(R) Results Announced at XVII European Stroke Conference
9. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
10. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
11. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... , Sept. 2, 2015  Array BioPharma Inc. ... Chief Executive Officer, Ron Squarer , will ... in Boston.  The public is welcome to participate ... Array BioPharma website.Event: Wells Fargo Securities Healthcare ConferencePresenter: ... 10, 2015Time:  , 10:20 a.m. Eastern Time Webcast: ...
(Date:9/2/2015)... , Sept. 2, 2015 ... revenue base with highly profitable specialty products ... Near-term growth potential with 11 product applications pending ... IV certifications  , Provides medium and longer ... development, including eight controlled substances , Adds ...
(Date:9/2/2015)... Sept. 2, 2015 Research and Markets ( http://www.researchandmarkets.com/research/l8z67c/pharmaceutical ... Affairs in China (Basel, Switzerland - November 26-27, 2015)" ... provide a detailed overview of the key areas of pharmaceutical ... Hong Kong , Macau and ... - All important aspects of gaining and maintaining a ...
Breaking Medicine Technology:Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 2Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 3Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 4Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 5Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 6Pharmaceutical Regulatory Affairs in China Seminar: Basel, Switzerland - November 26-27, 2015 2
... today announced the,publication of the results from a ... cruciate ligament (ACL) reconstruction,surgery. OMS103HP is an investigational ... and is designed to improve postoperative,knee function and ... return to work. The article titled "Novel Drug ...
... PHILADELPHIA, Aug. 25 Scientists have,discovered gene mutations ... the childhood cancer neuroblastoma. In addition, the researchers found,that ... forms of,non-inherited neuroblastoma, the more common form of the ... first genetic tests to families,affected by the inherited form ...
Cached Medicine Technology:Omeros Announces Publication of Clinical Results for OMS103HP in Arthroscopy: The Journal of Arthroscopic and Related Surgery 2Gene That Causes Childhood Cancer Neuroblastoma Is Found 2Gene That Causes Childhood Cancer Neuroblastoma Is Found 3Gene That Causes Childhood Cancer Neuroblastoma Is Found 4
(Date:9/3/2015)... ... September 03, 2015 , ... The new ... Report of Provo, Utah. The Clinicians Report is a leading information source to ... located throughout the U.S. Whiter Image's In-Office whitening kits were favorably validated for ...
(Date:9/3/2015)... ... ... Local filmmakers and now co-hosts of the up and coming podcast Path11 ... had great success in launching their Path11 Podcast with 23 episodes released since April ... is the well known Spiritual Catalyst and Linda Howe, leader in the field of ...
(Date:9/3/2015)... ... September 03, 2015 , ... The partnership ... customer and technical support services to promote LodonalTM in Nigeria. The distribution will ... the efficacy and safety of the product. , Managing Director, Fidson Healthcare Plc, ...
(Date:9/2/2015)... ... ... One can hardly argue against the fact that more and more people are using ... are being used as GPS, to make purchases, and yes, even to find a ... can now join the prestigious social ranks of e-dating. , Recently, Mr. Josh ...
(Date:9/2/2015)... Poulsbo, WA (PRWEB) , ... September 02, 2015 , ... ... store, open September 2015. “It was a simple decision, really,” says Chris. “We have ... shop here. They know the brands that work best for them—so we’ve given them ...
Breaking Medicine News(10 mins):Health News:Whiter Image Products Get Positive Rating From The Clinicians Report 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 3Health News:Fidson Partners US Firms on New Product Marketing 2Health News:Fidson Partners US Firms on New Product Marketing 3Health News:Fidson Partners US Firms on New Product Marketing 4Health News:Herpes-datingsites.com Recently Added Reviews of 5 STD Dating Apps for STD Positive Singles 2Health News:Harrison's Comfort Footwear Announces Expansion with New CHarrison Online Store 2
... are worried, as the floodplains of the Yamuna river are ... and even hotels for the 2010 Commonwealth Games. ... danger for the city's water security, they warn. ... weekend at Rajghat in New Delhi. It is being organized ...
... Taser to control agitated suspects in police custody is ... In some circles, however, the idea that using a ... controversy. ,Now, the final results of a ... of California, San Diego (UCSD) Medical Center showed no ...
... on black silk. The imagery is powerful and the prospect ... have turned to cocaine in a big way, throwing ... for instance, once hailed as a brilliant advocate, is ... naked and unconscious last Friday in a hotel room by ...
... positive effect on someones physical health? This question is ... of the latest Medical Journal of Australia. ... and spirituality in health, its relevance to Australian practitioners ... practice, and the current gaps where more research is ...
... hydropower projects being clean, a new scientific study has ... for at least 19 percent of India's global ... study, Indian dams are larger methane emitters and total ... around 33.5 million tonnes (MT) per annum, including emissions ...
... in the mouth like a popular breath-freshener could someday ... The innovative drug-delivery system was developed by Johns ... two-semester course, the seven-student team fabricated a thin film ... the child to swallow the vaccine. The dissolved medication ...
Cached Medicine News:Health News:Green Campaigners Concerned About Yamuna's Shrinking Floodplains 2Health News:Healthy Humans Not Harmed By Taser 2Health News:Australia Agonising Over the Problem of Cocaine Use by Lawyers 2Health News:Australia Agonising Over the Problem of Cocaine Use by Lawyers 3Health News:Students Devise Oral Quick-dissolve Strips for Rotavirus Vaccine 2Health News:Students Devise Oral Quick-dissolve Strips for Rotavirus Vaccine 3
The Perfecta PDA components provide the design and material choice imperative in today's cost conscious medical climate....
Cementless hip stem revisions offering optimal version setting for each patient. Compatible with modular link ceramic or cobalt chromium femoral heads with up to 4 neck lengths, or the link saddle de...
The proximally modular S-ROM Total Hip System provides custom capability at non-custom prices and is competitive with conventional porous coated systems....
The proximally modular S-ROM Total Hip System provides custom capability at non-custom prices and is competitive with conventional porous coated systems....
Medicine Products: