Navigation Links
Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting
Date:5/15/2008

g therapy.

Hepatic impairment: Metabolism of Tasigna is mainly hepatic. Tasigna has not been investigated in patients with hepatic impairment. Caution is recommended in these patients and QT interval should be monitored closely.

Drug interactions: Avoid concomitant use of QT prolonging drugs and strong inhibitors or inducers of CYP3A4 should be avoided as they may affect serum concentration of Tasigna.

Concomitant strong CYP3A4 inhibitors

The concomitant use of strong CYP3A4 inhibitors should be avoided (including, but not limited to, ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole). Should treatment with any of these agents be required, it is recommended that therapy with Tasigna be interrupted. If interruption of treatment with Tasigna is not possible, patients who require treatment with a drug that prolongs QT or strongly inhibits CYP3A4 should be closely monitored for prolongation of the QT interval, and a dose reduction to 1/2 the daily dose is recommended (400 mg once daily). If the strong inhibitor is discontinued, a washout period should be allowed before Tasigna is adjusted upward to the indicated dose. Close monitoring for prolongation of the QT interval is indicated for patients who cannot avoid strong CYP3A4 inhibitors. Grapefruit products and other foods that are known to inhibit CYP3A4 should also be avoided.

Concomitant strong CYP3A4 inducers

The concomitant use of strong CYP3A4 inducers should be avoided (including, but not limited to, dexamethasone, phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital). Patients should also refrain from taking St John's Wort. If patients must be co-administered a strong CYP3A4 inducer, the dose of Tasigna may need to be increased, depending on patient tolerability. If the strong inducer is discontinued, the Tasigna dose should be reduced to the indicated dose. Ta
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Intercell AG to Acquire Iomai Corporation to Expand Late Stage Product Pipeline and Strengthen Leadership in Vaccine Innovation
2. Spirit II Results Support Strength of Boston Scientifics Two Drug-Eluting Stent Platforms
3. BD and PEPFAR Collaborate to Strengthen Laboratory Systems in Fight Against HIV/AIDS and TB
4. Par Pharmaceutical Begins Shipment of Additional Dosage Strength of Generic TOPROL-XL(R)
5. Major Deficiencies in Design; Funding of Clinical Trials Affects Future of Scientific Innovation
6. Inverness Medical Innovations to Present at CIBC World Markets 18th Annual Healthcare Conference on November 7, 2007
7. Abbotts m2000(TM) Molecular Diagnostic Instrument and RealTime HIV-1 Test Win Chicago Innovation Award
8. OrbusNeichs Genous(TM) Bio-Engineered R Stent(TM) is Subject of Sessions on Innovation at TCT 2007
9. StatSure Signs Strategic Financing and License Deals with Inverness Medical Innovations
10. Cleveland Clinic Summits to Focus on Cardiovascular Medical Innovation
11. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... Biotech Ltd. (Nasdaq: SVA ), a leading provider ... that it will release its unaudited financial results for the ... May 28, 2013.  The Company will host a conference call ... 28, 2013 at 8:00 p.m. China Standard Time) to review ... corporate developments. To access the conference call, please ...
(Date:5/16/2013)... and MECHELEN, Belgium , May 17, ... (NYSE: ABBV ) announced today an extension ... disease.  Galapagos will fund and complete a Phase 2 ... rapid progression into Phase 3.  Upon successful completion of ... Galapagos $50 million.  The terms of the collaboration extension ...
(Date:5/16/2013)... May 16, 2013  Today, the National Patient Advocate ... House of Representatives recently approved a bill that ... charging patients higher out-of-pocket fees for newer, more expensive ... which have more severe side-effects. However, the bill was ... which will continue to be a barrier to patients ...
Breaking Medicine Technology:Sinovac to Host Conference Call to Report First Quarter 2013 Unaudited Financial Results 2Sinovac to Host Conference Call to Report First Quarter 2013 Unaudited Financial Results 3AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 2AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 3AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 4AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 5AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 6National Patient Advocate Foundation Responds to N.C. State House Approval of Flawed Cancer Treatment Fairness Bill 2National Patient Advocate Foundation Responds to N.C. State House Approval of Flawed Cancer Treatment Fairness Bill 3
... just 21 days, CVS/pharmacy,s ninth annual in-store fundraising campaign to ... $4.1 million. The funds raised by the campaign will be ... the funding of new clinical research aimed at developing new ... of finding a cure for ALS. This donation brings the ...
... Pharmaceuticals, Inc. (Nasdaq: IDIX ), a biopharmaceutical ... for the treatment of human viral diseases, today announced ... the 61st Annual Meeting of the American Association for ... 2010 in Boston, Massachusetts). The abstracts being presented are ...
Cached Medicine Technology:ALS Research Gets a $4.1 Million Boost from CVS/pharmacy Fundraising Campaign 2ALS Research Gets a $4.1 Million Boost from CVS/pharmacy Fundraising Campaign 3Idenix Announces Data Presentations at the 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) 2Idenix Announces Data Presentations at the 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) 3
(Date:5/18/2013)... The California College of Ayurveda Spa is ... Ayurvedic Spa , the client receives stress relief therapies ... lifestyle recommendations and stress management techniques by a Clinical ... traditional healthcare system of India. It is based on ... basis for all optimum health. Ayurveda believes that where ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 The ... Gov. John A. Kitzhaber, M.D., (D) to sign a ... by prohibiting minors under the age of 18 from ... become the third state in the nation to enact ... enacted similar indoor tanning bans for minors. Nationwide, 34 ...
(Date:5/18/2013)... Dr. Robert Tracey, an area leader in dental laser ... of the root causes of sleep apnea to provide and ... Sleep Month, Dr. Tracey points out estimates revealing that 40 ... sleep apnea is one of the most common of all. ... breathing at different times while sleeping. When this happens, the ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Scott Tischler of ... 90 days. These five keys to losing weight played a ... and support of Scott Tischler, Troy was able to lose ... any weight loss program should be approached with caution and ... These are the five keys to weight loss that Scott ...
(Date:5/18/2013)... 18, 2013 John Ravera, D.D.S., a ... of a new member to his dental team, Courtney Marino. ... the field for over 10 years. She received her degree ... was elected a member of Sigma Pi Alpha, a national ... enjoys working with patients of all ages, helping them understand ...
Breaking Medicine News(10 mins):Health News:Ayurveda Spa Treatments Now Offered at the California College of Ayurveda Panchakarma Center 2Health News:ASDSA Urges Oregon Governor to Sign Under-18 Indoor Tanning Restrictions 2Health News:Pomona, NY Dentist, Dr. Robert Tracey of General & Laser Assisted Dentistry (GLAD) Highlights Sleep Apnea Dentistry Services for Better Sleep Month 2Health News:Pomona, NY Dentist, Dr. Robert Tracey of General & Laser Assisted Dentistry (GLAD) Highlights Sleep Apnea Dentistry Services for Better Sleep Month 3Health News:Newport Beach Cosmetic Dentist John Ravera Adds New Member to Dental Team 2
... shelf life of foods, manufacturers often add hydrogen to ... results in the production of trans fats, ... cholesterol and increasing the risk for coronary heart disorders. ... shortenings, some margarines, crackers, cookies and snacks. Health authorities ...
... involved as salmonella outbreak action continues; Girl Scouts, Hershey and ... 23 (HealthDay News) -- More than 200 peanut butter and ... recalled so far in the ongoing salmonella outbreak, according to ... Web site. , As the number of people sickened ...
... coalition of Texas public health organizations this week ... for a comprehensive, statewide smoke-free workplace law that ... of secondhand smoke.(Logo: http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO ) The new ... of secondhand smoke, the growing number of states ...
... 23 Anthem Blue Cross and Blue Shield,in Wisconsin ... to support over 1,000 not-for-profit organizations in 2009 as ... company of Anthem,Blue Cross and Blue Shield will match ... than $1.3 million. , "Every ...
... Calif., Jan. 23, 2009 A therapy developed at UC ... world,s first embryonic stem cell treatment tested in humans. , ... on work by a research team led by Hans Keirstead, ... Research Center, for a clinical trial in patients with acute ...
... Studies find three separate links with sleep apnea, , , ... linked to obesity have also been tied independently to ... progression of liver disease, and living a less-than-active life ... common breathing disorder, regardless of people,s weight, according to ...
Cached Medicine News:Health News:How natural oils can be hydrogenated without making unhealthy trans fats 2Health News:How natural oils can be hydrogenated without making unhealthy trans fats 3Health News:More Than 200 Peanut Butter Products Now Under Recall 2Health News:More Than 200 Peanut Butter Products Now Under Recall 3Health News:Texas Public Health Groups Launch Ad Campaign About Need for Comprehensive, Statewide Smoke-Free Law 2Health News:Texas Public Health Groups Launch Ad Campaign About Need for Comprehensive, Statewide Smoke-Free Law 3Health News:Anthem Blue Cross and Blue Shield Associates Pledge More Than $900,000 to Community Organizations 2Health News:Anthem Blue Cross and Blue Shield Associates Pledge More Than $900,000 to Community Organizations 3Health News:UCI behind world's first embryonic stem cell study in humans 2Health News:Problems Tied to Obesity Also Seem to Affect Sleep 2Health News:Problems Tied to Obesity Also Seem to Affect Sleep 3
... VITROS HBsAg assay is the ... the U.S. Food and Drug,Administration ... a random,access format on the ... Now you can run an,HBsAg ...
... use as a quality assurance ... M (IgM) antibodies to hepatitis ... IgM antibodies to hepatitis A ... e antigen (HBeAg) and total ...
... antibody gives positive staining of prostatic ... hyperplasia. In cases of prostatic cancer, ... give definite but weak staining or ... cells; this pattern of staining permits ...
... Wampole Laboratories offers a comprehensive line of ... serum and urine in convenient one-step stick ... 2 testing options. Clearview Easy HCG is ... convenient stick format. Clearview HCG II ...
Medicine Products: