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Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting
Date:5/15/2008

TA because of the potential harm to the unborn child. While on ZOMETA therapy, you should avoid becoming pregnant.

Osteonecrosis of the jaw (ONJ) has been reported mostly in cancer patients receiving treatments, including intravenous bisphosphonates, chemotherapy, and/or corticosteroids. The majority of reported cases have been associated with dental procedures such as tooth extraction. You should maintain good oral hygiene and should have a dental examination with appropriate preventive dentistry prior to treatment with bisphosphonates. While on treatment, you should avoid invasive dental procedures if possible. No data are available as to whether discontinuation of bisphosphonate therapy reduces the risk of ONJ in patients requiring dental procedures. A connection between the use of bisphosphonates and ONJ has not been established. Based on your condition, your doctor will determine the treatment plan you will receive.

In postmarketing experience, severe and occasionally incapacitating bone, joint, and/or muscle pain has been reported infrequently in patients taking bisphosphonates.

ZOMETA contains the same active ingredient as found in Reclast(R) (zoledronic acid). If you are treated with ZOMETA, you should not be treated with Reclast.

You should take an oral calcium supplement of 500 mg and a multiple vitamin containing 400 IU of vitamin D daily.

It is important to keep up with your fluid intake while on ZOMETA therapy. Signs and symptoms of low fluid intake include thirst, sagging skin, low urine output, and dry mouth. Be sure to drink plenty of water or other fluids.

Please see enclosed full Prescribing Information in the ZOMETA resource book.

Tasigna Safety Information

WARNING: QT PROLONGATION AND SUDDEN DEATHS

Tasigna prolongs the QT interval. Sudden deaths have been reported in patients receiving nilotinib. Tasigna should not be used in patients with hypokalemia, hypomagnesemia, or long QT syndr
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SOURCE Novartis Pharmaceuticals Corporation
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