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Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting
Date:5/15/2008

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non-squamous non-small cell lung cancer patients receiving ASA404

(Abstract #8072: Sunday, June 1, 2008; 2:00 PM-6:00 PM CDT).

Novartis Oncology Products and Compounds

Zometa is currently used for the prevention of skeletal-related events (pathological fractures, spinal compression, radiation or surgery to bone, or tumor-induced hypercalcemia) in patients with advanced malignancies involving bone.

RAD001 (everolimus) is an investigational oral once-daily inhibitor of mTOR, a protein that controls tumor cell division and blood vessel growth. Everolimus is approved under the trade-name Certican(R) for the prevention of organ rejection in heart and kidney transplant recipients. Certican was first approved in the EU in 2003 and is available in more than 60 countries.

Tasigna(R) (nilotinib) is a next-generation tyrosine kinase inhibitor recently approved in the US and EU as second-line therapy for patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML).

ASA404 is an investigational small-molecule Tumor-VDA that selectively disrupts existing tumor blood vessels.

Zometa Safety Information

ZOMETA is generally well tolerated. The most common side effects you may experience with ZOMETA therapy are fatigue, nausea, vomiting, bone pain, headache, fever, shortness of breath, anemia, constipation, or lack of appetite. These side effects with ZOMETA were usually mild and transient. Your doctor may recommend a mild pain reliever to make you more comfortable.

In some cases, ZOMETA and other bisphosphonates have been known to cause kidney damage. Prior to each infusion, your doctor will routinely do blood tests to monitor your kidney function. If you have kidney problems, your doctor may decide that you need a lower dose of ZOMETA or that ZOMETA should not be given. Patients with severe kidney problems should not receive ZOMETA.

If you are pregnant, you should not receive ZOME
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SOURCE Novartis Pharmaceuticals Corporation
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