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Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting

ovartis is a leader in delivering potential new cancer treatments and in demonstrating productive collaboration with key investigators across the intricate spectrum of cancer research."

Six Novartis oncology compounds are currently in late-stage development with the potential for registration over the next five years. These compounds include RAD001 (renal cell carcinoma and other cancers), ASA404 (non-small cell lung cancer), SOM230 (Cushing's disease, refractory carcinoid tumors and acromegaly), LBH589 (cutaneous T-cell lymphoma and other cancers), EPO906 (ovarian cancer), and PKC412 (acute myelogenous leukemia and aggressive systemic mastocytosis).

Other highlights of data to be presented include:

-- The first results from the CALGB trial 79809, of the effects of Zometa

on bone mineral density in premenopausal women who develop ovarian

failure due to adjuvant chemotherapy (Abstract #512: Saturday, May 31,

2008; 5:00 PM-5:15 PM CDT).

-- Results from a Phase II study of bevacizumab and RAD001 in the

treatment of advanced renal cell carcinoma (RCC) (Abstract #5010:

Saturday, May 31, 2008; 2:00-PM-2:15 PM CDT).

-- Data from a multicenter Phase I clinical trial of daily and weekly

RAD001 in combination with weekly paclitaxel and trastuzumab in

patients with Her2-overexpressing metastatic breast cancer with prior

resistance to trastuzumab (Abstract #1003: Monday, June 2, 2008; 4:30

PM-4:45 PM CDT).

-- Analysis of results from a Phase II study of RAD001 in patients with

recurrent endometrial carcinoma (Abstract #5502: Sunday, June 1, 2008;

5:30 PM-5:45 PM CDT).

-- Updated Phase II results on Tasigna in patients with imatinib-resistant

chronic myeloid leukemia in chronic phase (Abstract #7010: Monday, June

2; 10:30 AM - 10:45 AM CDT).

-- Phase II data comparing safety and efficacy between squamous an

SOURCE Novartis Pharmaceuticals Corporation
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