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Stemline Therapeutics Announces Two Presentations of Direct Injection Synthetic Peptide Vaccine for Brain Cancer, Now Being Developed as SL-701, at the Annual Meeting of the American Association of Cancer Research (AACR)
Date:4/18/2012

developed by Stemline as SL-701, demonstrated both immunological and clinical activity in children with malignant glioma.

In the adult study, conducted at the University of Pittsburgh and other centers, adult patients with low-grade glioma (LGG) were treated with the Pitt vaccine via direct subcutaneous injection every three weeks for eight courses. Twenty-four HLA-A2-positive patients were enrolled, including 13 with newly diagnosed high-risk LGG without prior radiotherapy, one with newly diagnosed high-risk LGG with prior radiotherapy, and 10 with recurrent LGG. Side effects were minimal with one grade 3 fever. Sustained and specific immune responses, as assessed by ELISPOT assays, were observed in the majority of evaluable patients. The research team on the adult study led by Dr. Hideho Okada at Pitt, reported that, although a thorough evaluation of progression-free survival would require a longer observation period, among 17 patients who completed eight courses, 10 had stable disease. The team concluded that the Pitt vaccine, now being developed by Stemline as SL-701, was well tolerated and demonstrated immune responses in high risk adult patients with LGG.

About Stemline Therapeutics, Inc.

Stemline Therapeutics, Inc. is a clinical stage biopharmaceutical company developing novel oncology therapeutics that target both cancer stem cells (CSCs) as well as the tumor bulk. Among Stemline's drug candidates are SL-401 and SL-701, both of which have demonstrated single agent clinical activity in Phase I/II studies of advanced cancer patients. In a multicenter Phase I/II trial in patients with advanced acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), SL-401 demonstrated single agent activity, including durable complete responses (CRs), and an overall survival (OS) improvement relative to historical data in the most heavily pretreated AML patients. In addition, SL-401 was well-tolerated and was not toxic to the bone marrow. S
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