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Stemline Therapeutics Announces Two Presentations of Direct Injection Synthetic Peptide Vaccine for Brain Cancer, Now Being Developed as SL-701, at the Annual Meeting of the American Association of Cancer Research (AACR)
Date:4/18/2012

NEW YORK, April 18, 2012 /PRNewswire/ -- Stemline Therapeutics, Inc. announced that trial results of two clinical studies of direct injection synthetic peptide vaccine, now being developed as SL-701, in both adults and children with advanced brain cancer were selected for late-breaking presentations at the Annual Meeting of the American Association for Cancer Research (AACR) held from March 31 to April 4, 2012 in Chicago, IL. SL-701 is comprised of synthetic peptides corresponding to epitopes of targets overexpressed on glioblastoma multiforme (GBM) and other high-grade and low-grade gliomas and administered via direct subcutaneous injection. The data were presented by investigators at the University of Pittsburgh (Pitt), who developed the direct injection synthetic peptide vaccine. In 2009, the University of Pittsburgh licensed patent rights relating to the vaccine to Stemline.

In the pediatric study conducted by the Pitt team and led by Dr. Ian Pollack, 27 children were enrolled, including 16 with newly diagnosed brainstem glioma (BSG), five with newly diagnosed cerebral high grade glioma (HGG), and six with recurrent gliomas. Children were treated with the Pitt synthetic peptide vaccine, administered via direct subcutaneous injection, every three weeks for up to eight courses. Among 22 evaluable children who were HLA-A2-positive, three had sustained partial responses (PRs) including one exceeding 15 months, one had prolonged disease free status following surgery, and 14 had stable disease lasting longer than three months. In addition, the results of ELISPOT immunological assays revealed specific T-cell responses to the intended targets in six of seven children evaluated. Systemic side effects were minimal. Tumor pseudoprogression, which is transient tumor enlargement due to inflammation followed by tumor stabilization or shrinkage, occurred in four children. The research team concluded that the direct injection synthetic peptide vaccine, now being
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