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Star Scientific and Rock Creek Pharmaceuticals Report on the Beneficial Nutritional Effects of Anatabine in an Animal Model of Ulcerative Colitis
Date:3/19/2013

ower levels of disease activity.  Anatabine treatment significantly reduced diarrhea and watery stool during induction of the inflammatory condition.  Anatabine supplementation after inflammation was established was less conclusive because mice in both the anatabine and control groups decreased the amount of water they drank by almost 50% during the first few days of the recovery regimen.  Therefore, the amount of anatabine received by the anatabine treated group of mice was much lower than intended during recovery.

The initial results of this study suggest that anatabine dietary supplementation may prevent the recurrence (flare up) of ulcerative colitis or reduce the severity of symptoms in vulnerable individuals.  Although the results from the longer-term treatment phase of the study were inconclusive, the significant reduction in clinical manifestations of some features of bowel inflammation with preventative treatment suggests that anatabine supplementation may interfere with the excessive and prolonged production of inflammatory molecules that leads to these clinical outcomes.  Work at the University of Virginia is ongoing to determine whether anatabine administration interfered with the expression of pro-inflammatory cytokines and other markers of inflammation in gastrointestinal tissue samples.  Based on the initial primary results of this pre-clinical study, a study of the safety and effects of anatabine supplementation in human ulcerative colitis may be warranted.

Dr. Curtis Wright , Medical and Clinical Director of Rock Creek Pharmaceuticals, said, "Animal models of human disease are not always predictive of benefits in humans, but when individual patient reports are consistent with an animal model in a controlled laboratory study the findings reinforce each other. We provided the study materials and appropriate funding to the University of Virginia in support of the investigators'
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SOURCE Star Scientific, Inc.
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