Navigation Links
Star Scientific Reports Publication of First Peer-Reviewed Article on the Effects of Anatabine in an Animal Model of Multiple Sclerosis
Date:1/31/2013

e array of inflammatory genes including cytokines, suggesting a mechanism by which anatabine antagonizes pro-inflammatory cytokine production.

In addition, the researchers found that anatabine reduced the infiltration of inflammatory cells in the brain and significantly prevented demyelination in the spinal cord of EAE mice. In humans, demyelination in the spinal cord is associated with muscle weakness and paralysis in MS. Therefore, the researchers concluded that the "data suggest that anatabine may be effective in the treatment of MS."

Dr. Michael Mullan , President and CEO of the Roskamp Institute, commented, "The most remarkable results were the clear inhibition of brain inflammation and the degeneration of the spinal cord by anatabine and the accompanying inhibition of the severe paralysis that usually accompanied the model."

Dr. Daniel Paris , the primary author of the article and Head of Research and Development at the Roskamp Institute, added, "The oral administration of anatabine potently reduced the neurological deficits and abrogated the pathological lesions in the spinal cord that are responsible for the development of paralysis in this mouse model of multiple sclerosis (MS). In addition our work also explains the beneficial activity of anatabine in this MS model by showing that this compound prevents the activation of key molecules that orchestrate the propagation of inflammation in the central nervous system and the periphery."

The full title of the study is, "Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine," and can be viewed here: http://dx.plos.org/10.1371/journal.pone.0055392. This study builds upon earlier research conducted by the Roskamp Institute, which showed that the natural alkaloid anatabine displays anti-inflammatory properties and readily crosses the blood brai
'/>"/>

SOURCE Star Scientific, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Boston Scientific Announces CE Mark and European Launch of Emerge™ PTCA Dilatation Catheter
2. Shire to Present Scientific Data Across Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting May 5-9
3. Boston Scientific and Philips Healthcare Announce Collaboration to Enhance Imaging Equipment Offering
4. Boston Scientific Announces Positive Data From Lotus™ Transcatheter Aortic Valve Trial
5. One-Year EVOLVE Trial Clinical Results Confirm Comparable Safety And Effectiveness Data Of The Boston Scientific SYNERGY™ Stent Versus PROMUS Element™ Platinum Chromium Stent
6. Generex Announces New Members of Antigen Express Scientific Advisory Board for the AE37 Breast Cancer Vaccine
7. Boston Scientific Announces FDA Approval and U.S. Launch of EPIC™ Vascular Stent
8. Generex Augments Antigen Express Scientific Advisory Board
9. Receptos to Deliver Scientific Presentation at Digestive Disease Week 2012 about the Therapeutic Role of RPC1063 in Inflammatory Bowel Disease
10. Boston Scientific Endoscopy Presents Promising Clinical Data During Digestive Disease Week ®
11. Lilly Diabetes Presents Phase II Blood Pressure and Heart Rate Data on Investigational GLP-1 Analog Candidate, Dulaglutide, in Patients with Type 2 Diabetes at the 27th American Society of Hypertension Scientific Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... July 30, 2014 Reportlinker.com announces that ... its catalogue: mHealth and Home Monitoring ... Executive summary mHealth ... to better outcomes, decreased costs and improved sustainability ... solutions is still in an early stage, but ...
(Date:7/30/2014)... Stryker brand ambassadors Fred Funk and ... Champions Tour event near Minneapolis, MN , which ... . Stryker is the official joint replacement products company of the ... 1 st through Sunday, August 3 rd , fans will ... health destination located in the Pioneer Press Expo tent located near ...
(Date:7/30/2014)... July 30, 2014 Silicon Valley Bank, the ... study today that examines the merger, acquisition and ... companies.  According to the annual report based on 2013 ... returns since SVB started tracking the data in 2005. ... Built on solid healthcare M&A activity over the last ...
Breaking Medicine Technology:mHealth and Home Monitoring - 6th Edition 2mHealth and Home Monitoring - 6th Edition 3mHealth and Home Monitoring - 6th Edition 4mHealth and Home Monitoring - 6th Edition 5mHealth and Home Monitoring - 6th Edition 6mHealth and Home Monitoring - 6th Edition 7mHealth and Home Monitoring - 6th Edition 8mHealth and Home Monitoring - 6th Edition 9mHealth and Home Monitoring - 6th Edition 10mHealth and Home Monitoring - 6th Edition 11Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 2Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 3Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 4Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 5Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3
... Allow All Patients Access to Nexavar, WAYNE, ... Pharmaceuticals (NYSE: BAY ) and Onyx Pharmaceuticals, ... planned review by an independent data,monitoring committee (DMC) ... progression free survival, and,time to progression in an ...
... Australia, Aug. 24 Physicians at Southern,Health have started ... of a new strategy for defeating hepatitis C viral ... world. Implicit Bioscience,s drug, oglufanide disodium, which works ... given by intranasal,administration to patients with chronic hepatitis C ...
Cached Medicine Technology:Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial 2Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial 3Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial 4Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial 5Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial 6Drug in New Hepatitis C Clinical Trial 2
(Date:7/30/2014)... (PRWEB) July 30, 2014 It is said ... proved this to be true as a product sponsor ... in Las Vegas this past June. , Lash Affair ... and overall success of the eyelash industry through collaboration so ... proud to have supported NEESA ’s event. Lash Affair’s ...
(Date:7/30/2014)... mutation linked to obesity respond differently to pictures of ... not have the genetic mutation, according to a new ... Clinical Endocrinology & Metabolism ( JCEM ). , ... results from a combination of eating too much, getting ... of appetizing foods that are high in calories can ...
(Date:7/30/2014)... Texas (PRWEB) July 30, 2014 The ... (2013-18)” provides an insight into the market dynamics and ... report covers the actual and forecasted market sizing of ... various factors fuelling the demand of the same. It ... segment and major players in the market. Further, the ...
(Date:7/30/2014)... July 30, 2014 Dialogic ... today announced that DollarPhone, the largest privately owned ... the Dialogic® ControlSwitch™ softswitch to offer ... number portability (LNP) to both its wholesale and ... ControlSwitch is able to power DollarPhone’s network infrastructure, ...
(Date:7/30/2014)... HealthDay Reporter , TUESDAY, July ... might set the stage for harmful health habits, including eating ... conducted from 1982 to 2012 also found a link between ... younger a woman was when she started her first diet, ... control behaviors -- like vomiting or laxative misuse," said study ...
Breaking Medicine News(10 mins):Health News:Lash Affair Launches a New Product as Sponsor of the First U.S. Lash Extension Competition 2Health News:Brain response to appetizing food cues varies among obese people 2Health News:Global Pulse Oximetry Market 2018 Opportunities and Trends Now Available at MarketReportsOnline.com 2Health News:Global Pulse Oximetry Market 2018 Opportunities and Trends Now Available at MarketReportsOnline.com 3Health News:DollarPhone Expands Prepaid and Wholesale Offerings With Enhanced Dialogic ControlSwitch 2Health News:DollarPhone Expands Prepaid and Wholesale Offerings With Enhanced Dialogic ControlSwitch 3Health News:Dieting at Young Age Often Backfires, Study Says 2Health News:Dieting at Young Age Often Backfires, Study Says 3
... analysis of records of pancreatic surgery during the last ... pancreatic cancer surgeon// Charles J. Yeo, M.D., Samuel D. ... College of Thomas Jefferson University and Thomas Jefferson University ... his colleagues have revealed that contrary to what many ...
... major intestinal surgery, including stomach reduction for obesity, may ... results of the study have been published in the ... findings on three patients with increasingly poor eyesight or ... the space of a year. None of the patients ...
... A number of Canadians are more obese ... smoking less, according to a new national health survey// . ... Canada, on Tuesday, revealed that there was an underestimation ... by approximately nine per cent. The survey also indicated ...
... that a man is very critical and is suspected to have ... in a Shenzhen hospital. It is very evident that the virus ... Health Protection said that the victim lives in Shenzhen and is ... residing in Shenzhen. He fell ill after he visited a wet ...
... Families who fear the transfer of genetic diseases to their progeny ... a major NHS bank of babies' stem cells//. ,Stem ... to treat diseases such as leukemia. However cord blood banking has ... public as well as clinicians, wherein blood is taken from the ...
... warn the number of New Zealanders who take party pills ... authorities argued taking// party pills escape people from taking drugs. ... used the pill atleast once – says researchers commissioned by ... physical and psychological parts such as sleeplessness, loss of appetite, ...
Cached Medicine News:Health News:Pancreatic Cancer Surgery Successful in 80-Year-Olds 2Health News:Pancreatic Cancer Surgery Successful in 80-Year-Olds 3Health News:Incidence Of Smoking Less, Obesity More, in Canada: StatsCan 2Health News:Bank of Stem Cells to Give Hope to Sick Children 2